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1. |
Leptomeningeal Carcinomatosis and Intramedullary Spinal Cord Metastases from Lung CancerDetection with FDG Positron Emission Tomography |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 905-907
TSUYOSHI KOMORI,
DOMINIQUE DELBEKE,
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摘要:
A 64-year-old man with a history of large-cell lung carcinoma and recent resection of a brain metastasis was examined because of a general decline in his ability to function. Whole-body positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG PET) showed metastases along the spinal cord that were confirmed with MRI. Intramedullary spinal cord metastasis occurs rarely, and the prognosis is extremely poor. Whole-body FDG PET allows the entire spinal cord to be examined noninvasively compared with magnetic resonance imaging, computed tomography, and myelography.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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2. |
Effect of Dietary Intake Before F-18 FDG Positron Emission Tomographic Scanning on the Evaluation of a Solitary Pulmonary Nodule |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 908-909
BUDDHIWARDHAN OJHA,
SCOTT BARTLEY,
SAI GUNDLAPALLI,
JAMES MOUNTZ,
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摘要:
The uptake of fluorine-18 fluorodeoxyglucose (F-18 FDG) by a malignant tumor depends on the blood glucose level. The authors present a striking case that illustrates the importance of blood glucose measurement in F-18 FDG positron emission tomographic (PET) imaging in a patient with a solitary pulmonary nodule. With the emergence of freestanding imaging centers, this case emphasizes the importance of using an objective method, such as a glucometer, to measure blood glucose levels before F-18 FDG PET imaging. Results of the initial scan were equivocal (the patient had eaten before the scan), whereas a hypermetabolic focus was clearly identified on a second scan obtained 2 days later.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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3. |
Tc-99m–Labeled Somatostatin Receptor-Binding Peptide Imaging for a Pulmonary Nodule |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 910-912
RICHARD MOREHEAD,
WEI-JEN SHIH,
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摘要:
A 76-year-old man with chronic obstructive pulmonary disease and a smoking history had a 2-cm solitary pulmonary nodule that was likely to be malignant. He underwent Tc-99m–labeled somatostatin receptor-binding peptide SPECT. A computed tomographic–guided transthoracic needle biopsy performed before the SPECT was nondiagnostic. SPECT showed increased uptake of the tracer by the nodule, which was subsequently found to be adenocarcinoma by surgical resection. Differentiation of malignant from benign nodules by Tc-99m–labeled somatostatin imaging may be a reasonable approach in patients at high risk for cancer and concurrently at increased risk for complications from invasive diagnostic procedures or surgical resection.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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4. |
Focal Pulmonary Uptake During Tc-99m Myocardial Perfusion SPECT Imaging |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 913-915
SEONG-MIN KIM,
HEE-SEUNG BOM,
HO-CHEON SONG,
HWAN-JEONG JEONG,
JUNG-JUN MIN,
MING-HAO LI,
JAE-TAE LEE,
SEOK-TAE LIM,
JI-YEUL KIM,
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摘要:
PurposeTo evaluate the incidence and origin of abnormal focal pulmonary uptake during myocardial perfusion SPECT imaging (MSPECT).MethodsFor evaluation of chest pain, 790 men and 581 women (mean age, 56 ± 13 years) underwent MSPECT. All of them received adenosine for pharmacologic stress and Tc-99m tetrofosmin (TF, n = 817) or Tc-99m sestamibi (MIBI, n = 554) for myocardial perfusion imaging.ResultsReview of chest radiography with or without computed tomography revealed 111 (8.1%) focal pulmonary diseases. Among them, 38 (34.2%) showed focal pulmonary uptake (TF, 22; MIBI, 16); 27 (30.7%) of 88 showed previous pulmonary tuberculosis; 2 of 10 (20%) benign pulmonary nodules; 4 of 5 (80%) metastatic lung cancers; 2 of 4 (50%) primary lung cancers; and 3 of 4 (75%) pneumonias. No difference in uptake was noted for the two imaging agents. Intensity of uptake did not vary with origin of the uptake. Focal abnormal pulmonary uptake was found in 2.8% of patients undergoing MSPECT and in 34.2% of patients in whom radiological examinations showed regional pulmonary disease. In patients with abnormal pulmonary uptake on MSPECT, 16% had a malignant lesion, whereas 75% of patients with a pulmonary nodule shown on radiography and focal pulmonary uptake on MSPECT had a malignant lesion.ConclusionsAlthough the incidence of abnormal pulmonary uptake during MSPECT was very low, the incidence of malignant lesions in the patients with nodular pulmonary uptake was relatively high.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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5. |
Reversal of Medial Compartment Osteoarthritic Uptake Pattern After High Tibial Osteotomy |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 916-918
WARWICK BRUCE,
SAM MACDESSI,
HANS VAN DER WALL,
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摘要:
Two cases of osteoarthritis of the knee are presented that illustrate the typical medial compartment pattern of scintigraphic uptake. In both cases the patients had significant medial joint pain. After high tibial osteotomy, the pattern of uptake was altered and paralleled the improvement in symptoms. These observations prompt several important issues regarding the cause of the uptake and may provide a way to monitor treatment response.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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6. |
Rhenium-188 HEDP To Treat Painful Bone Metastases |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 919-922
SIJIN LI,
JIANZHONG LIU,
HONG ZHANG,
MEI TIAN,
JIN WANG,
XIAOGE ZHENG,
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摘要:
PurposeRhenium-188 hydroxyethylidine diphosphonate (HEDP) is a new and attractive radiopharmaceutical that localizes in skeletal metastases and emits beta particles that may be therapeutically beneficial. In this study, the therapeutic efficacy of Re-188 HEDP was investigated in an uncontrolled initial trial of 61 patients with different types of advanced cancer for the palliation of painful bone metastases.Materials and MethodsSixty-one patients with painful bone metastases of lung, prostate, breast, renal, rhinopharyngeal, and bladder cancers were treated with 1.1 GBq (31 mCi) to 6.9 GBq (188 mCi) Re-188 HEDP. After treatment, the patients were followed at weekly intervals for the first 2 months and monthly thereafter for as long as 1 year. Hematologic function tests were also performed before and after treatment for 6 weeks. Pain responses were scored according to a three-point pain-rating scale as complete, significant, and minimal.ResultsPrompt and significant relief of bone pain occurred in 80% of patients overall. Of the specific tumor types, pain relief was achieved in 77% of patients with lung cancer, in 80% with prostate cancer, in 83% with breast cancer, in 100% with bladder cancer, in 50% with renal cancer, in 50% with rhinopharyngeal cancer, and in 87% of patients with other tumor types, with no severe side effects or hematopoietic toxicity.ConclusionThis large clinical trial verified that Re-188 HEDP is a useful radiopharmaceutical agent to treat painful bone metastases from various tumor types.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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7. |
Clinical Impact of Differential Renal Function To Indicate and Assess Pyeloplasty and the Significance of Coexisting Vesicoureteral Reflux |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 923-929
TOBIAS SCHUSTER,
MAXIMILIAN STEHR,
BERND RO&bgr;MÜLLER,
HANS DIETZ,
KLAUS HAHN,
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摘要:
PurposeIn patients with ureteropelvic junction obstruction (JPJO) who are conservatively treated, 5% to 10% of them show a deterioration of renal function without recovery after delayed pyeloplasty. Should surgery be indicated based on observed deterioration of differential renal function (DRF)? Can we expect improvement of the DRF after pyeloplasty? What other influencing parameters may affect DRF?Materials and MethodsIn this study, the authors examined 85 ureterorenal junctions that had undergone the Anderson-Hynes technique for surgical correction of UPJO. Based on the values obtained from the preoperative DRF (Tc-99m mercaptoacetyltriglycine), the cases were separated into three categories: group I had poor DRF (less than 11% of total renal function [TRF]), group II had moderate DRF (11% to 33% of TRF), and group III had adequate DRF (more than 33% of TRF). Twelve months after surgery, renal function was reassessed. The results were correlated with age at surgery, symptoms, coexisting vesicoureteral reflux, and drainage.ResultsSeven ureterorenal junctions (8%) comprised group I, 15 (18%) comprised group II, and 63 (74%) comprised group III. After UPJO repair, 13% showed marked improvement in DRF, 86% remained stable, and 1% exhibited diminished function. In 50% of the renal cases with preoperative DRF less than 33%, postoperative improvement was seen. In follow-up renal scans, 30 cases (35%) revealed nonobstructive drainage, whereas the remaining 53 junctions (62%) showed moderate delayed drainage. Both the moderate delayed group (57%) and the nonobstructive group (50%) showed similar DRF improvement. Sixty-six percent of the patients with impaired DRF improved after pyeloplasty performed within the first 3 months of life, compared with 42.8% of patients in whom surgery was performed after 5 years of age. Vesicoureteral reflux was evident in 27.2% of the patients with preoperative impaired DRF compared with 11% with normal DRF. Forty-five percent of the patients with impaired DRF and no improvement after surgery had coexisting vesicoureteral reflux, compared with 9% of those with postoperative improvement.ConclusionsSustained renal impairment after pyeloplasty is likely as a result of preexisting renal dysplasia with vesicoureteral reflux. Moderate delayed drainage after surgery does not affect DRF. Surgery for UPJO should be indicated independent of a DRF follow-up (except very low DRF) or the age at the time of diagnosis.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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8. |
Skull Base Involvement by a Nasopharyngeal Carcinoma Shown by Tc-99m MDP SPECT But Not by Computed Tomography |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 930-932
SHABANA SAEED,
SAIF HAQ,
MOHAMMAD SOHAIB,
ALI KHAN,
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摘要:
PurposePlain radiographs, computed tomography (CT), and more recently magnetic resonance imaging (MRI) are used routinely to stage carcinoma of the nasopharynx. Tc-99m methylene diphosphonate (MDP) SPECT is seldom used for local staging of the disease.Materials and MethodsPlain radiographs and CT were used to stage squamous carcinoma of the nasopharynx in a 50-year-old man with a left XII nerve palsy.ResultsFindings of the plain radiographs were normal, whereas the CT scan revealed a nonhomogenous hyperdense mass in the nasopharynx but intact underlying bone. Given the symptoms, a Tc-99m MDP planar scan was ordered and showed no enhanced uptake, but SPECT images obtained at the same time revealed markedly increased focal radiotracer uptake in the region of the tumor, indicating osseous involvement.ConclusionPossible bony invasion with a nasopharyngeal carcinoma may be better shown with MDP SPECT than with planar isotope bone scans, plain radiographs, or CT.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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9. |
Diagnosis of Complete Ectopic Lingual Thyroid with Tc-99m Pertechnetate Scintigraphy |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 933-935
CUMALI AKTOLUN,
HAKAN DEMIR,
FATMA BERK,
K. METIN KIR,
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摘要:
The authors present four cases of ectopic lingual thyroid disease diagnosed by Tc-99m pertechnetate scanning, which is an efficient diagnostic tool that yields high-quality images in this clinical setting.
ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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10. |
Jejunal Diverticular Hemorrhage Localized by Red Blood Cell Scintigraphy |
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Clinical Nuclear Medicine,
Volume 26,
Issue 11,
2001,
Page 936-937
DAVID SCHUSTER,
WILLIAM CHAPMAN,
ERNEST AHL,
PAUL AHEARNE,
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ISSN:0363-9762
出版商:OVID
年代:2001
数据来源: OVID
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