摘要:

Mathematics plays an essential role in epidemiology. Whether simple questions are asked about simple relations, or complicated questions about complicated relations, the best fitting mathematical figures are always searched for. In a holistic approach, it may often be necessary to assess complicated relations by using (real) mathematical models (simulation models). Examples are presented of parasitic contamination cycles which require more or less complicated mathematics to answer epidemiological questions regarding prevalence and incidence of infection in the human population: Trichinella, Toxocara and Toxoplasma. Some general remarks on epidemiological insights which are necessary to understand abstract concepts of the ‘real world’ (mathematical modelling), are discussed.

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694126

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

The history of academic education in food microbiology and hygiene in the Netherlands has largely been written by Prof Kampelmacher. The first contribution in this field dates from 1961, and suggested a new approach to teaching Veterinary Public Health. His later research led to the conclusion that intervention would be the only way to control the food transmitted diseases originating from slaughter animals and poultry, particularly Salmonellosis. This intervention should take place at the beginning of the contamination cycle. In the 1970's, surveys showed that feed decontamination would no longer efficiently control the endemicity of Salmonellosis. The contamination cycles had become autonomous. Consequently, emphasis on terminal decontamination of food products was necessary. Besides his activitities in teaching and research, Prof Kampelmacher masterminded a modern view of the responsibilities of academic scientists. Moreover, he strongly promoted an interdisciplinary approach to scientific consultation and advice. In this respect, he has unfortunately not been successful in introducing radiadation of dangerously contaminated food, having met strong opposition from various quarters. His efforts in multidisciplinary training and research programmes resulted in, among other things, fruitful cooperation between the Agricultural University at Wageningen and the Faculty of Veterinary Medicine at Utrecht University.

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694127

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

The present investigation was undertaken to demonstrate saturable β2‐adrenoceptor binding sites on cell membranes of bovine lymphocytes by means of the non‐selective antagonist (3H) dihydroalprenolol. Although the classical density gradient centrifugation technique was used as described for the isolation of these cells from human blood, striking differences in binding characteristics were observed. It is suggested that differences in physical properties of blood might be responsible for these phenomena. Since receptor density and affinity of β2‐adrenoceptors in lymphocytes are used in human medicine (and will be in the future in veterinary medicine) for correlation with several physiological and pathophysiological conditions, attention is drawn to the effect of dilution of blood during the preparation of these cells; in lactating cows, the best results were obtained with the dilution 1: 0.5.

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694128

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

The snail Cepaea hortensis is able to acetylate and hydroxylate sulphamethoxazole in a similar way to man. About one percent deacetylation, but no hydroxylation of N4‐acetysulphamethoxazole takes place. The relative rates of the metabolic pathways for hydroxylation and acetylation of sulphamethoxazole are equal.

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694129

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

The turtle Pseudemys scripta elegans is able to hydroxylate and acetylate Sulphamethoxazole in a way that is comparable to man, i.e the rate and yield of hydroxylation equals that of the acetylation. The hydroxy metabolites 5‐hydroxy‐ and N4‐acetyl‐5‐hydroxysulphamethoxazole are not glucuronidated. N4‐acetysulphamethoxazole is neither deacetylated nor hydroxylated.

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694130

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694131

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

ISSN:0165-2176    

DOI:10.1080/01652176.1987.9694115

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor