ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694989

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

The results of an L‐asparaginase‐based continuous chemotherapy protocol (n = 52) versus a short doxorubicin‐based induction chemotherapy protocol (n = 65) were evaluated in 117 dogs with malignant lymphoma. There were no differences between the two groups in patient characteristics or incidence of protocol‐related toxicity. Complete remission was induced in 71.2% of the dogs treated with the Lasparaginase protocol and in 67.7% of the dogs treated with the doxorubicin‐plus protocol. The calculated Kaplan‐Meier one‐ and two‐year survival fractions in the L‐asparaginase group were 48% and 26%, and in the doxorubicin‐plus group 35%, and 22%, respectively. Differences in remission and survival between the two treatment groups were not significant. A multivariate Cox proportional hazards survival analysis revealed that elevated pretreatment plasma creatinine concentration and prior treatment with prednisolone were associated with shorter survival times. An elevated pretreatment plasma creatinine concentration and total leucocyte count were associated with a decrease in the disease‐free period. Differences in efficacy and toxicity between the two protocols were not significant. There is no apparent advantage in using the continuous L‐asparaginase protocol, and the shorter doxorubicin‐plus protocol is less expensive and less time consuming.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694990

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

Serum samples from 102 veterinarians and 191 pig farmers from the southern part of the Netherlands were investigated for antibodies againstBrucella abortus, Leptospiraspp,Streptococcus suisserotype II, Hantavirus (HV), and lymphocytic choriomeningitis virus (LCMV). All samples were collected in 1993 and stored until this study was performed. The prevalence of antibodies againstB. abortusin veterinarians (4.5%) was significantly higher (P=0.01) than in pig farmers (0%). None of the veterinarians (0%) and only one pig farmer (0.5%) had antibodies againstLeptospira spp.. Furthermore, significantly (P=0.015) more veterinarians (6%) than pig farmers (1%) had antibody titres against muramidase‐released protein (MRP), a protein of pathogenic S. suis serotype II strains. None of the veterinarians and a total of 3 (1.6%) pig farmers had antibody titres against HV. The prevalence of antibodies against LCMV tended to be higher in pig farmers (2.6%) than in veterinarians (0%) (P=0.10). It can be concluded that the prevalence of antibodies against the investigated zoonotic agents in veterinarians and pig farmers is low.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694991

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

Tissues from Dutch family dogs symptomatic for borreliosis according to established criteria and from infected but asymptomatic dogs were tested forBorrelia burgdorferisensu lato DNA using a polymerase chain reaction. Subsequently,B. burgdorferisensu stricto,B. garinii, B.afzelii, andB.valaisianawere identified by hybridization. Symptomatic dogs showed a higher prevalence ofBorreliain liver samples (9 of 15) than asymptomatic dogs (9 of 43) p= 0.0049. Overall,B. garinii was the most prevalent species and occurred together with up to three other species in one liver sample.B. burgdorferisensu stricto however, was predominantly detected in samples of synovial membranes, skin, cerebrospinal fluid, bladder, heart, and bone marrow. Nine out of 10 symptomatic dogs with a very high antibody titre were positive for Borrelia DNA by PCR in one or more of these tissues. We conclude that dissemination in naturally infected European dogs occurres and that the two most prevalent species,B. burgdorferisensu stricto andB.garinii, differ in their tropism.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694992

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

This article describes a case of massive mortality among horses which was probably due to intoxication by pyrrolizidine alkaloids fromHeliotropium indicum. Over 4 years more than 75% of a population of about 110 horses on a farm in Costa Rica died after showing nervous neurological symptoms. Two clinical manifestations were encountered, an acute and a chronic one, both with a fatal outcome. Pathological findings in 2 horses coincided with those reported in the literature for intoxication by pyrrolizidine alkaloids and were not specific for VEE. However Venezuelan equine encephalitis (VEE) was the main differential diagnosis and could not completely be excluded because this disease was endemic in the region and VEE titres were found to be high. Taxonomic and toxicological investigations implicatedHeliotropium indicumas the most probable principal cause of the intoxication.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694993

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

A 2‐year‐old Basset hound with unilateral persistent hyperplastic tunica vasculosa lentis and primary vitreous is described. There was leukokoria in the left eye, caused by bluish‐white polar densities and haemorrhagic discoloration in the nucleus of the lens. Ultrasonographic examination of the eye revealed a small hyperechoic lens and a hyperechoic linear soft‐tissue strand extending from the posterior pole of the lens through the optic disc. Power Doppler imaging revealed blood flow in this persistent hyaloid artery, but 5 months later, immediately prior to surgery, there was no flow in this artery. Ultrasonography, including Power Doppler imaging, was useful to confirm the diagnosis and to estimate the complications of surgery, especially the risk of vitreal haemorrhage after cutting of the persistent hyaloid artery. Comparison of the ultrasonographic images with those obtained by computed tomography suggested that the resolution of computed tomography is inadequate for identifying structures as fine as a persistent hyaloid artery.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694994

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

Fish fillets (n= 1760) sold on the Belgium market were examined for Anisakidae larval infection. Seven sea fish species were examined by means of the candling technique over a period of 4 months, from November 1996 to February 1997. Third‐stage larvae of Anisakis simplex andPseudoterranova decipienswere identified. A. simplex was the most abundant species with a prevalence of 84.5%, and was found in 192 of the examined fillets (10.9%). Pollock (Pollachius pollachius) was the most heavily infected fish species (82.9%). The prevalence in cod (Gadus morhua), saithe (Pollachius virens), and whiting (Merlangius merlangus) was 34.7%, 26.7%, and 15.4% respectively. The prevalence in the three other fish species examined was low, namely 8.9%, 6.6%, and 3.8% for ling (Molva molva), catfish (Anarchias lupus), and Northeast red fish (Sebastes marinus), respectively. Pollock was the fish species with the largest number of Anisakis larvae (7.8 larvae/kg fish fillet).

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694995

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor

摘要:

The immune responsiveness of cows with hepatic lipidosis (fatty liver) in comparison to control cows with a normal liver fat content was tested by applying skin allotransplants to the skin of the back of cows on day 3 after parturition. Immunoreactivity was determined by semi‐quantitative counting of the number of infiltrating lymphocytes in the recipient skin adjacent to the allotransplants during a period of 21 days. There were more invading lymphocytes in samples from control cows than there were in samples from cows with hepatic lipidosis. It was concluded that cows with hepatic lipidosis have a reduced lymphoid response to skin allotransplants.

ISSN:0165-2176    

DOI:10.1080/01652176.1999.9694996

出版商:Taylor & Francis Group    

年代:1999

数据来源: Taylor