ISSN:1059-0501    

DOI:10.1080/10590509809373501

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1059-0501    

DOI:10.1080/10590509809373502

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

摘要:

This work reviews the literature concerned with the carcinogenesis of silicon in humans. Many of the studies deal with large cohorts of industrial workers. We sort these according to the type of silicon exposure and its consequences. An association of silica dust and fibers with lung and stomach cancers is widely reported and still other types of cancer are linked to silicon exposure. The risk is far greater if silicosis is present. On the other hand, still other studies show no association between silicon and cancer in humans, especially when confounding variables such as smoking and concomitant exposure to other carcinogens are taken into consideration. Though the literature is controversial, the weight of evidence nevertheless strongly supports an important role for silicon in the production of cancer in humans.

ISSN:1059-0501    

DOI:10.1080/10590509809373503

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

摘要:

Chromate is a human carcinogen. Since it does not form a covalent DNA adductin vitrounder physiological conditions, and is not mutagenicin vitroin the presence of cytochrome P450 preparations from liver, reduction of Cr6+by cellular reductants to lower oxidation states such as Cr5+, Cr4+is considered to be a critical step in the mechanism of carcinogenesis.

ISSN:1059-0501    

DOI:10.1080/10590509809373504

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1059-0501    

DOI:10.1080/10590509809373500

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor