|
|
| 11. |
Modulation by Social Status of the Relationship between Cerebrospinal Fluid and Serum Cortisol Levels in Male Talapoin Monkeys |
| |
Neuroendocrinology,
Volume 42,
Issue 5,
1986,
Page 436-442
Joe Herbert,
Eric B. Keverne,
Usanee Yodyingyuad,
Preview
|
PDF (1148KB)
|
|
摘要:
Serum and cerebrospinal fluid (CSF) cortisol were measured by radioimmunoassay in male talapoin monkeys living in social groups. The slopes of the regressions between cortisol in the two compartments were significantly less in dominant than either the most subordinate males or those of intermediate rank. Furthermore, the dominants’ CSF also contained proportionately more cortisol than was predicted from the overall regression analyses of the groups of which they were members. There was no difference in the proportion of ‘free’ cortisol (that is, not bound to serum proteins) between the serums of dominant or subordinate males. These findings point to an association between social status and the distribution of cortisol between blood and CSF in these mo
ISSN:0028-3835
DOI:10.1159/000124483
出版商:S. Karger AG
年代:1986
数据来源: Karger
|
| 12. |
Pre- and Postnatal Influence of an Estrogen Antagonist and an Androgen Antagonist on Differentiation of the Sexually Dimorphic Nucleus of the Preoptic Area in Male and Female Rats |
| |
Neuroendocrinology,
Volume 42,
Issue 5,
1986,
Page 443-448
Klaus D. Döhler,
Art Coquelin,
Fred Davis,
Melissa Hines,
James E. Shryne,
Petra M. Sickmöller,
Barbara Jarzab,
Roger A. Gorski,
Preview
|
PDF (1311KB)
|
|
摘要:
The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We tried to clarify the differential role played by androgens and estrogens during development and differentiation of the SDN-POA by treating male and female rats during an extended pre- and postnatal period either with the estrogen antagonist tamoxifen or with the androgen antagonist cyproterone acetate. Treatment with tamoxifen did not alter serum levels of testosterone in male rats during the perinatal period, but it inhibited development and differentiation of the SDN-POA. Pre- and postnatal treatment of male rats with cyproterone acetate resulted in female phenotypic appearance, but it had no influence on differentiation of the SDN-POA. Perinatal treatment of female rats with tamoxifen resulted in permanent anovulatory sterility, but did not influence SDN-POA differentiation. Treatment of female rats with cyproterone acetate had no influence on SDN-POA differentiation or on the capacity to ovulate. Since pre- and postnatal treatment of male rats with cyproterone acetate is known from previous studies to feminize sexual behavior patterns and to retain the mode for cyclic gonadotropin release, and since the same treatment did not influence differentiation of the SDN-POA in the present study, it may be concluded that the SDN-POA is not directly involved in the control of female sexual behavior and in the control of the gonadotropic hormone release pattern. The results further indicate that development and differentiation of the SDN-POA is primarily under estrogenic, not under androgenic control.
ISSN:0028-3835
DOI:10.1159/000124484
出版商:S. Karger AG
年代:1986
数据来源: Karger
|
|
首页
