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| 11. |
Intra- and Extrahypothalamic Luteinizing Hormone-Releasing Hormone (LHRH) Distribution in the Rat with Special Reference to Mesencephalic Sites Which Contain Both LHRH and Single Neurons Responsive to LHRH |
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Neuroendocrinology,
Volume 31,
Issue 1,
1980,
Page 66-72
W.K. Samson,
S.M. McCann,
L. Chud,
C.A. Dudley,
R.L. Moss,
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摘要:
In addition to hypothalamic sites known to contain LHRH, several extrahypothalamic structures in both male and female rats were discovered to contain the decapeptide. In the mesencephalon, the fasciculus retroflexus, interpeduncular nucleus and midbrain central grey contained readily detectable quantities of LHRH. Single neurons responsive to microiontophoretically applied LHRH were also discovered in the mesencephalon suggesting a physiological role for the decapeptide in neuronal events at the level of the midbrain.
ISSN:0028-3835
DOI:10.1159/000123052
出版商:S. Karger AG
年代:1980
数据来源: Karger
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| 12. |
Biphasic Fluctuation of Pituitary Responsiveness to LH-RH during the Rat Estrous Cycle |
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Neuroendocrinology,
Volume 31,
Issue 1,
1980,
Page 73-80
J.A. Vilchez-Martinez,
E. Pedroza,
A. Arimura,
A.V. Schally,
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摘要:
The role of the endogenous LH-RH and gonadal steroids on the fluctuation of the pituitary responsiveness to an analog of LH-RH in rats was studied. A specific sheep serum against LH-RH and a superactive analog of LH-RH [D-AIa6, desGly-NH210]LH-RH ethylamide, which does not cross-react with the LH-RH antiserum, were used. In control animals, the pituitary response to 400 ng of LH-RH varied during the estrous cycle, the greatest responses being on the days of proestrus (P) and estrus (E) and the lowest on diestrus 1 (DI) and diestrus II (DII). A similar pattern was observed in the same animals when 10 ng of [D-Ala6, desGly-NH210]LH-RH ethylamide were used. In animals treated with anti-LH-RH serum, the LH response to the analog was greater than that in control rats on day I (DI) and day 2 (DII) and was smaller on day 3 (P) and on day 4 (E). The magnitude of the pituitary responsiveness to the analog in animals treated or not with the anti-LH-RH serum depended to some extent on the serum progesterone/estradiol ratio. The antiserum against LH-RH lowered the high serum levels of estradiol which are normally seen on P and E but not of progesterone. This indicates that a possible extraovarian source of progesterone exists, possibly from the adrenals. In conclusion, the cycling fluctuation of the plasma progesterone/estrogen ratio in the female rat could act at the pituitary level to modify LH-RH action.
ISSN:0028-3835
DOI:10.1159/000191160
出版商:S. Karger AG
年代:1980
数据来源: Karger
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| 13. |
Announcement |
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Neuroendocrinology,
Volume 31,
Issue 1,
1980,
Page 80-80
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PDF (81KB)
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ISSN:0028-3835
DOI:10.1159/000123053
出版商:S. Karger AG
年代:1980
数据来源: Karger
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