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Dopaminergíc Mediation ofβ-Endorphin-Induced Prolactin Secretion |
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Neuroendocrinology,
Volume 31,
Issue 4,
1980,
Page 292-296
Glen R. Van Loon,
Errol B. De Souza,
Seon H. Shin,
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摘要:
Intracisternal administration of synthetic human β-endorphin increases plasma prolactin concentration, and this effect is blocked by naloxone. Drugs which stimulate dopamine receptors (apomorphine or bromocriptine) or increase availability of dopamine (pargyline) inhibited the effect of β-endorphin on plasma prolactin. Drugs which antagonize dopamine receptors (haloperidol) or decrease availability of dopamine (α-methyltyrosine) potentiated the effect of β-endor-phin on plasma prolactin. Some of these drugs act only in neurons and not in anterior pituitary, supporting a brain site of action for these drug interactions with β-endorphin which altered prolactin secretion. These pharmacological studies provide support for a concept of dopaminergic mediation of β-endorphin-induced prolactin secr
ISSN:0028-3835
DOI:10.1159/000123091
出版商:S. Karger AG
年代:1980
数据来源: Karger
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