摘要:

Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY might have a role in the onset of maternal behavior at parturition, we have used both antisera to OXY and an analog antagonist of OXY, d(CH2)5–8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a pregnancy-terminated preparation which yields reliable short-latency maternal behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of antisera to OXY or of the i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin on the latency to respond to pups were tested by presenting pups 48 h after surgery and EB treatment. Behavioral observations were made for the next 5 h and periodically over the next 5 days. Groups receiving either the antisera to OXY or the analog antagonist had significantly longer latencies to respond to pups than did control groups. In a separate experiment, i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin was shown to have no effect on the performance of maternal behavior in lactating rats 5 days postpartum. These results suggest that OXY may have a role in promoting short-latency maternal behavior in steroid-primed female rats, but that it is probably not involved in sustaining this behavior during lact

ISSN:0028-3835    

DOI:10.1159/000124125

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Intracerebroventricular administration of 0.01–1.0 µg of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) to mice reduced morphine-induced feeding. Administration of FMRFamide also inhibited feeding induced by a 24-hour period of food deprivation. These results suggest that FMRFamide or FMRFamide-like neuropeptides play an important role in the control of opioid-mediated feedi

ISSN:0028-3835    

DOI:10.1159/000124126

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A double-label electron microscopic immunostaining procedure was employed to examine the interconnections of glutamic acid decarboxylase(GAD)- and LHRH-immunoreactive neurons in the medial preoptic area of the rat. The results provide ultrastructural evidence that GABA-ergic neurons establish symmetric (Gray II) synapses on LHRH neurons.

ISSN:0028-3835    

DOI:10.1159/000124127

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000124128

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000124129

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000124130

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000124114

出版商:S. Karger AG    

年代:1985

数据来源: Karger