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| 11. |
Dopaminergic and Cholinergic Influences on the Growth Hormone Response to Growth Hormone-Releasing Hormone in Man |
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Neuroendocrinology,
Volume 45,
Issue 3,
1987,
Page 243-247
Giuseppe Delitala,
Mario Palermo,
Richard Ross,
David Coy,
Michael Besser,
Ashley Grossman,
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摘要:
It is well established that compounds that modify dopaminergic and cholinergic activity in man may induce changes in circulating growth hormone (GH). We have, therefore, investigated the effect of a dopamine agonist, bromocriptine, and a dopamine antagonist, domperidone, as well as a muscarinic cholinergic antagonist, pirenzepine, on the GH response to an analogue of GH-releasing hormone (GHRH) in normal male subjects. GHRH(1–29)NH2 induced a rise in serum GH that was augmented by bromocriptine, antagonized by pirenzepine, but was unaltered by domperidone. As this dose of GHRH(l-29) NH2 has been shown to be maximally stimulatory to GH release, it is suggested that there are dopamine stimulatory and cholinergic inhibitory receptors to GH release independent of GHRH in ma
ISSN:0028-3835
DOI:10.1159/000124732
出版商:S. Karger AG
年代:1987
数据来源: Karger
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| 12. |
Announcements |
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Neuroendocrinology,
Volume 45,
Issue 3,
1987,
Page 248-248
Preview
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PDF (121KB)
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ISSN:0028-3835
DOI:10.1159/000124733
出版商:S. Karger AG
年代:1987
数据来源: Karger
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