摘要:

To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p < 0.001) in serum Prl were observed at 120, 180, and 240 min following the oral administration of metergoline (Met) (4 mg; N = 34) and methysergide (Meth) (3 mg; N = 20) in comparison with placebo. No significant difference was found in the degree of Prl suppression induced by these two serotonin antagonists and by the dopaminergic drug bromocriptine (Br) (2.5 mg; N = 20). After Pim pretreatment (1 mg every 6 h for 7 days) the elevated serum Prl levels were reduced to 27.1% ± 8.1 (SEM) of basal after Met and to 54.5% ± 8.9 after Meth administration (N = 5 for each study). It is concluded that Met and Meth inhibit Prl secretion by mechanisms which are not or only partially related to dopaminergic receptors. These data are consistent with a stimulatory role for serotonin in human Prl releas

ISSN:0028-3835    

DOI:10.1159/000122753

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Permanent semi-microelectrodes were implanted in the ventromedial hypothalamus (VMH), lateral hypothalamus (LH), amygdala (AMYG), medial forebrain bundle (MFB), anterior hypothalamus (AH), inferior colliculus (IC), and caudate nucleus (CN). Average evoked responses were recorded simultaneously from the above sites in freely behaving rats before and after administration of pentagastrin (100 μg/kg), secretin 1 μg/kg or cholecystokinin octapeptide (CCK-OP) (1 μg/kg) in search of satiety signal. Gastrin and secretin had little effect while it appears that CCK may perform a regulatory function in a neurohumoral feedback mechani

ISSN:0028-3835    

DOI:10.1159/000122754

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Adrenergic (α and β), cholinergic (m and n) and gabanergic (γ) influences on the regulation of basal hypothalamo-hypophyseal-adrenocortical (HHA) activity, as assessed by plasma cortisol levels, were investigated in non-stressed conscious cats. Alterations in neurotransmitter activities were induced by perfusing the cerebroventricles for 60 min with mock cerebrospinal fluid containing α, β, m, n and γ antagonists given alone or in various combinations. Neither γ, m nor n blockers altered basal HHA activity, whereas both α and β blockers given alone or together, or combined with m, n and γ blockers markedly elevated plasma cortisol. These responses were inhibited by the addition of dexamethasone to the perfusion fluid. These data suggest that basal HHA activity in the cat is maintained by a central inhibitory action of the adrenergic system on spontaneously discharging corticotropin-releasing factor neurons, and not via an adrenergic-cholinergic-gabanergic neu

ISSN:0028-3835    

DOI:10.1159/000122755

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000122756

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000122757

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000122758

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0028-3835    

DOI:10.1159/000122752

出版商:S. Karger AG    

年代:1978

数据来源: Karger