摘要:

SummaryResting coccygeal blood pressure values were measured, indirectly, on 296 horses (97 Thoroughbreds, 97 Standardbreds and 102 hacks). Blood pressure was found to vary with the class of horse examined; on average Thoroughbreds had significantly higher values than Standardbreds and hacks, whereas blood pressures of the last two groups were not significantly different. There was no demonstrable effect of sex, height or heart rate on blood pressure, but temperature and age did influence the value recorded. Mean (± sd) (n = 296) coccygeal uncorrected values (systolic pressure/diastolic pressure) were 112.1 ± 16.5/77.3 ± 14.3 mmHg. Allowing for bladder width to tail girth ratios used in each measurement, actual coccygeal pressures of 122.8 ± 18.6/71.0 ± 13.4 mmHg were determined. The latter corresponded to values of 149.4 ± 19.0/97.6 ± 14.0 mmHg, when corrected to heart (shoulder) level. Normal limits (defined as within 2.5th and 97.5th percentiles) for all horses, regardless of class, were 80 to 144 mmHg/49 to 105 mmHg for coccygeal uncorrected values and 86 to 159 mmHg/45 to 97 mmHg adjusted for bladder width to tail girth

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01853.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01854.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SummaryThe pharmacokinetics of ascorbic acid were studied in 29 horses after intravenous (iv), subcutaneous, intramuscular (im) and oral administration. Following iv injection of 5 and 10 g ascorbic acid, respectively, a biphasic decline of ascorbic acid serum levels was found, indicating that the vitamin distributes in the body according to a two‐compartment open model. The apparent volume of distribution (average value for Vd(ss)= 0.6 litre/kg) was approximately equivalent to the volume of total body water. The terminal half‐life of the biexponential serum level‐time curve (t1/2β) varied between 5 and 17 h. Both distribution and elimination were found to be positively correlated with the iv dose administered. Following subcutaneous and im injection, the average bioavailability of ascorbic acid amounted to 82 and 61 per cent, respectively. However, both routes of administration gave rise to marked local irritation. Following oral administration, the systemic availability of ascorbic acid was very poor. Serum levels in most experiments were not increased above the endogenous pre‐administration values of the vitamin. Thus, in horses iv injection appears to be the only satisfactory route of administration of ascorbic acid if supplementation is

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01855.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01856.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SummaryMuscle perfusion was studied in conscious and anaesthetised horses by monitoring the clearance of a locally injected bolus of saline containing radioactive xenon (133Xe). The mean of all the measurements made from the brachiocephalicus and semimembranosus muscles in conscious subjects was 1.29 ml/min/100 g while in anaesthetised subjects it was 0.40 ml/min/100 g. The significance of these results is discussed in relation to the clinical occurrence of post anaesthetic myositis.

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01857.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01858.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01859.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0425-1644    

DOI:10.1111/j.2042-3306.1984.tb01860.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY