摘要:

abstract—In 25 patients with hypopituitarism the relation of skeletal and dental maturity and the effects on it of substitution therapy for 2–4 years were analyzed. Dental age was retarded less regularly and to a lesser degree than skeletal age and statural growth. In most patients dental age was within the range of 0–2 s.d. All components of dental development seemed equally retarded. Changes in dental delay during GH treatment were variable, but in most cases parallel to the changes in statural and skeletal delay. When treatment was discontinued the lag in dental age increased, showing a response similar to that of skeleta

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00633.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—The effects of a large dose of vinblastine sulfate (2 mg/kg body weight) on proliferating odontoblast precursors and secretory odontoblasts in the continuously growing rat incisor were studied. The rats were killed 6 h, 24 h, 3 d and 7 d after vinblastine injection. Most cells in the proliferating zone contained arrested mitoses, or had perished after 24 h. After 3 and 7 d, the odontoblasts derived from this zone were reduced in number, and showed altered cell shapes. The odontoblasts had produced irregular dentin. The secretory odontoblasts had displaced nuclei and altered cell shapes after 24 h. Those most affected were opposite early mineralized dentin. In some incisors the cells had perished. In the protracted experiments almost all the odontoblasts were changed and had produced abnormal dentin. In the early mineralized dentin area, accumulations of cells were present after 3 d, and osteodentin‐like material after

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00634.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—Alkaline phosphatase (EC 3.1.3.1.) in developing teeth and in bone has been studied. Prior to hard tissue function a rather high enzyme activity was noted in differentiating odontoblasts, stratum intermedium, and outer enamel epithelium. A lower activity was observed in the cells of the dental papilla and stellate reticulum. After the onset of hard tissue formation the alkaline phosphatase activity was generally increased. Enzyme activity was also found in the proximal part of tall, secretory ameloblasts. In the short post‐secretory ameloblasts a high enzyme activity was noted. At the onset of dentin mineralization there was an increase in enzyme activity in the cells of the subodontoblastic layer. In bone the highest alkaline phosphatase activity was found in osteoblasts. A difference was noted between the alkaline phosphatase of hard and soft tissues by means of the addition of inhibitors to the incubation media. Within the hard tissues it was possible to distinguish between two alkaline phosphatases after pretreatment with heat (56°C) or the addition of specific inhibitors (sodium metavandate, ortho‐and pyrophosphate). An isoenzyme which was sensitive to these procedures was demonstrated in odontoblasts and in the pulpal connective tissue. Another alkaline phosphatase isoenzyme, which was resistant to pretreatment with heat or the addition of vanadate or phosphate, was demonstrated in the subodontoblastic cell layer, stratum intermedium and the outer cells of the reduced enamel epit

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00635.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—The structural changes in human enamel during exposure to an acetate buffer, pH 4, containing 150 parts/106fluoride have been studied using scanning electron microscopy and polarized light microscopy. After exposure for 2 h the enamel surface was covered by a fine‐granular layer of calcium fluoride. The underlying enamel was highly eroded with an increased pore volume in the outer layer. Following an equilibration period of 3 months the uptake of fluoride in the apatite lattice had resulted in a highly mineralized, 100‐μm‐thick surface layer rich in fluoride covering a subsurface porous zone with an unchanged fluoride content. The deeply located, caries‐like porous zone may have provided calcium and phosphate for saturation of

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00636.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—Vincristine in doses of 0.1, 0.3, 0.5 and 0.7 mg/kg was administered to 60 rats in four groups. Histomorphologic investigation of the odontoblast population in the maxillary incisors revealed dose‐dependent reactions consisting of (1) swelling of the odontoblasts and an accumulation of abnormal mitotic cells in the germinative parts of the pulp after 5 h, (2) a supervening necrosis and destruction of some odontoblasts and of the mitotic cells after 24 h, and (3) after 3 d, a reversal to normal structure in some parts of the odontoblast population, but a further development of the vincristine‐induced changes, with severe cellular derangement and irregular predentin production, in o

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00637.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—A kindred affected with hereditary fibrous hyperplasia of the gingiva with varying penetrance and expressivity is described. Most of the affected members were short in stature. The pedigree strongly suggested an autosomal dominant mode of inheritance. The penetrance of the trait varied, and three unaffected persons had transmitted the disease to their offspring. There were two modes of expression. The mild form showed only bilateral rugose thickening of the palate, whereas the severe form showed gingival hyperplasia in addition to changes in the palatal mucosa. The changes were already present at birth. Histological examination showed large amounts of alcian blue‐positive extracellular material in the subepithelial connective tissue of the hyperplastic mucosa. Loose collagen‐poor connective tissue with alcian blue‐positive extracellular material and dense collagen‐rich connective tissue in the rugose projections of the palatal mucosa were often s

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00638.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—A clinical and radiographic reexamination of 2,459 roots 2–7 years after initial pulpectomy or root canal therapy is presented. The overall success rate, which was 53%, was not affected by the sex or age of the patient, or by the jaw in which the tooth was situated. The tooth group, however, had a significant influence on the success rate, the worst results being obtained for incisors and especially the mandibular central and maxillary lateral incisors. The prognosis was clearly better for the pulpectomies than for the root canal therapy. Mortal pulpectomy was found to succeed more often than vital. The presence of a primary periapical rarefaction worsened the success rate. The success rate was lower for the teeth in which a posttreatment prosthetic crown had been fitted. Fillings which went beyond the apex had a significantly lower success rate than those which nearly or exactly reached the a

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00639.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—Exfoliated cells of the human buccal mucosa were studied in 35 adults. All cells showed signs of necrosis: condensation of nuclear chromatin, dilated mitochondria with flocculent densities, dilatation of endoplasmic reticulum, ribosomes detached from the endoplasmic membranes, aggregates of degenerated organelles in the cytoplasm, and discontinuity of nuclear and plasma membranes. Desmosomes were preserved in cells exfoliated in groups, but in single cells the former sites of desmosomes were only occasionally identified. The cells contained filaments about 150 Å in diameter, often arranged in bundles around aggregates of degenerated organelles. Ruthenium red stained the glycocalyx of the epithelial cells and the capsule of accompanying bacteria. The glycocalyx did not appear to contribute to binding the bacteria to cell surfaces. The findings are discussed in the light of recent studies on cell necrosis, and culminate in a hypothesis to explain exfoliation of cells of the oral epitheli

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00640.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—The barrier property of inflamed palatal mucosa to water has been studied in eight adult edentulous persons with a generalized denture stomatitis, by measuring the transmucosal water flow under varying osmotic gradients. Flow rates were registered gravimetrically in solute saturated filter paper discs after 10‐min periods of mucosal contact, using solutions with an osmolarity of 0, 0.25, 0.30, 0.38, 0.50 and 0.75 osmol sucrose/1. The histology of the mucosal areas was evaluated from cytologic scrapings, and biopsy material from two persons. The inflow with use of pure water was 2.98 mg/cm2/10 min, being about three and a half times greater than through the intact mucosal surface. The point of isotony of the inflamed mucosa ranged between 0.30 and 0.36 with a mean value of 0.33 osmol/1, thus being of the same magnitude as in plasma and tissue fluid. The observations from the biopsy material were in accordance with earlier histological evidence from generalized denture stomatitis, indicating that the permeability properties of the inflamed mucosa belonged to epithelial cell layers located in the lower part of the spinous la

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00641.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

abstract—An experimental model of yeast‐induced denture stomatitis has been set up in the rat by inoculatingCandida albicanson the fitting side of a maxillary acrylic plate retained by an orthodontic band around the incisors. Thirty‐eight Wistar rats were used in two series of experiments with an observation period of 2 weeks. In each of the series there were one control and three experimental groups. Control rats were left untreated, while rats of the experimental groups wore either uninoculated or inoculated plates, or had their palatal mucosa smeared with the yeast. For cytologic examination the palate was scraped in Series I and the fitting side of the plate in Series II. After 1 week a generalized simple inflammation had developed in the palate of most animals of the experimental groups. It was most severe and persistent in rats with inoculated plates. Histologic signs of inflammation and hyphal formation were also most pronounced in this group. Hyphae did not invade the epithelium. Except for an initial loss of body weight, which was restored by day 10 or 12, the rats tolerated their plates. The Wistar rat seems to be well suited for experimental studies on denture stoma

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1978.tb00642.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY