摘要:

Abstract —Previous experiments have shown that tetracyclinecs may react with hydrosyapatite, e.g. in enamel and dentin, without losing their antimicrobial capacity. The present paper examines the pattern of pellicle and plaque formation on doxycycline‐treated dentin by the use of scanning electron microscopy (SEM). From newly extracted human teeth were prepared standardized dentin slabs, half of which were soaked in aqueous solutions of doxycycline HC1, 10 mg/ml (pH 2.5) for 10 min. Seven volunteers carried doxycycline‐impregnated specimens ligated to the buccal surface of a maxillary molar for 2 h, 8 h, 24 h and 120 h, respectively. Untreated control specimens were ligated to the contralateral teeth. After removal from the oral cavity, the dentin slabs were briefly rinsed in water, allowed to airdryand processed for SEM. SEM assessment of the specimens showed that doxycycline‐impregnation resulted in a superficial etching of the dentin, a reduced rate of pellicle formation as well as an impairment of pellicle adhesion, and a retarded bacterial plaque formation on the dentin s

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01370.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —Previous studies have shown that tetracyclines react with enamel and dentin in vitro to form slightly soluble compounds wish a pronounced and long‐lasting antimicrobial capacity. The purpose of the present project was to study the effect of doxycycline‐impregnation of dentin on the growth of oral microorganisms in vivo. Slabs of native human dentin were immersed in aqueous solutions of doxycycline HC1, 10 mg/ml, for 10 min, and were subsequently ligated to orthodontic brackets placed bucally on maxillary molars in seven individuals. Untreated native dentin specimens were similarly placed on contralateral teeth. Test and control specimens were removed from the oral cavity after 2 h, 24 h or 120 h, respectively. The individual specimens were then placed in 0.5‐ml saline and agitated mechanically for 30 s. The resulting bacterial suspensions were plated onto blood agar and various selective growth media. Based on CFUcounts obtained after incubation of the plates, doxycycline‐treated dentin specimens showed a significantly lower number of viable microorganisms after 2 h and 24 h in the oral cavity than did the control specimens. The bacterial growth was also less pronounced in the test specimens after 120 h. The effect of doxycycline was similar for all the cultivable bacteria. No significant difference in yeast growth was seen between test and control

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01371.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —369 adult patients with moderate to severe periodontitis were compared with a survey sample from the population of Stockholm regarding smoking habits. The results showed that the frequency of daily cigarette smokers was significantly greater in the periodontitis sample. The odds ratio for a smoker to appear among periodontitis patients was more than doubled as compared to the population at large. In addition, the periodontal variables of PII, GI, probing depth and the patient's experience of gingival bleeding were recorded and compared between smoking and non‐smoking patients. PII was found to be similar in smokers and non‐smokers. Signs and symptoms of gingivitis as evidenced by the patients' experience of gingival bleeding and by GI were less pronounced in patients who smoke. Only 25% of smokers reported bleeding gingiva as compared to 51 % of non‐smokers. No differences were observed regarding probing depth except for lingual pockets of the maxilla where a significantly greater probing depth was observed in smokers. It was concluded that smokers may run an increased risk for periodontitis. Furthermore, gingival inflammatory symptoms seem to be suppressed in patients wh

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01372.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —Interproximal subgingival marginal discrepancies of full coverage restorations were compared with adjacent crevicular fluid flow and percentage radiographic periodontal bone loss. A total of 88 patients with 116 premolar crowns were evaluated. Patients were selected at random from student treatment records, Institute of Dental Prosthetics, Royal Dental College, Copenhagen, Denmark. Crevicular fluid collected on filter paper strips from the interproximal area was stained with 0.2% ninhydrin solution and the length of the area measured. Marginal fit was determined by measuring the marginal excess or deficit recorded in a polyether impression. The amount of bone around each crowned tooth was measured on five times magnified prints of radiographs. Percentage bone loss was calculated by dividing the distance from the alveolar crest to the most coronal level at which the periodontal space retained its normal width by the distance from the alveolar crest to the root apex. Correlating marginal fit with crevicular fluid within gingival index scores showed r = 0.32 (G.I.l) and r = 0.42 (G.I.2). Fit vs percentage bone loss showed r=0.68 and r = 0.59, respectively (P<0.001). Differentiation was further made within the 0.0–0.2 mm range discrepancy by categorizing the data in four groups. Comparing fit relative to crevicular fluid and bone loss, most of these groups were significantly different when analyzed statistically using the Mann‐Whitney U‐Test. Small defects<0.050 mm were associated with significantly less fluid flow and bone loss than defects exceeding thi

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01373.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —The concentrations of IgA, lysozyme and β‐microglobulin (β2‐m) were quantitated in wax‐stimulated mixed saliva from 28 patients with severe periodontitis and from 28 healthy controls. The mutual correlations between IgA, lysozyme and β2‐rn were determined. In patients with periodontitis decreased lysozyme concentrations were detected when compared with controls (P<0.05). The correlation between IgA and β2‐m concentrations was highly significant in both groups studied (P<0.0001, andP<0.002), whereas β2‐m and lysozyme concentrations were positively correlated in patients but not in controls. In addition, a significant correlation between IgA and lysozyme was found only in periodontal

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01374.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —The ability to eliminate sugar from the oral cavity was studied in subjects with high or low numbers of salivary Streptococcus mutans and lactobacilli. The glucose concentration in saliva was determined after consumption of biscuits using the Gloxtest, and the logarithms of the glucose values were plotted against time. The sugar clearance time was measured where the slope of the plot intersected with a glucose level of I mg/ml. Subjects with a high level of S, mutans had a significantly longer clearance time than subjects with a low level. More salivary lactobacilli were found in a subject group‐ with a long sugar clearance time than in a group with a fast clearance r

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01375.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —The effect of 8 polyols and 14 aldoses or ketoses on the spontaneous aggregation of Ca‐proteinates was followed spectrophotometrically in supernatants and filtrates of human mixed saliva. Each carbohydrate was added to the saliva samples at 37°C and the precipitated material was analyzed for protein, total carbohydrate and Ca. Based on their effect on aggregation, the carbohydrates could be divided into three groups: 1) those that showed no effect on aggregation: D‐xylose, D‐ribose and i‐erythritol, 2) those that inhibited aggregation strongly: xylitol, Dsorbitol and D‐mannitoi, and 3) those that inhibited aggregation moderately: glucose, fructose and sucrose. The inhibitory effect of the above polyols on the aggregation of Ca‐proteinates varied greatly among the saliva donors, and correlated positively with the turbidity of the saliva and its protein content more than with the Ca‐concentration or the pH of the saliva sample. It is suggested that inhibition of aggregation shown the most clearly for xylitol, sorbitol and mannitol manifests itself as a retardation of the final, irreversible aggregation of those glycoproteins that already exist in a precipitated form and which are responsible for the tur

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01376.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —The purpose of the present investigation was to detect strains of small‐sized oral spirochetes isolated from subgjngival plaque for protease, peptidase, lipase, glycosidase, phosphatase, hyaluronidase and chordroitinsulfatase activites. The analyses were routinely carried out with cultures in the early stationary phase of growth after 4 days incubation. Both culture media and harvested spirochete cells were examined for the different enzyme activities. The enzymes were assayed by use of the API ZYM system, by p‐nitroanilide derivatized peptides, and by hydrolyzing of mucopolysaccharides incorporated in solid bacterial medium. Relatively strong activides of trypsin‐Hke enzymes, mainly bound to the cells, were observed in all strains. Similarly all strains showed acid phosphatases bound to the cells, too. Extracellular hyaluronidase‐ and chondroitinsulfatase activities were detected qualitatively in all strains after 7 days growth. The activities of the two mucopolysaccharide degrading enzymes almost disappeared after 10 subcultivatons. Weak lipase (butyrate), higher lipase (caprylate), and weak phosphoamidase activities‐were observed in all cell pellets. No glycosidase activities were found. The observations are discussed by regarding the spirochetal enzymes as potential virulence factors for the development of marginal pe

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01377.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —Retention of Cu in the mouth after rinses with aqueous solutions of CuSC4was measured by atomic absorption spectrophotometry. The retained amount of Cu exhibited a linear relationship against the concentration of the rinsing solution in the range tested. Approximately one third of the Cu retained after a 60 s rinse was retained within the first 15 s, and about 75% within 30 s. Retention of Cu was only little affected by the pH of the rinsing solution in the range from 2.0 to 5.7, being reduced by about 50% at pH 9.0. However, variations in cupric ion activity rather than pH per se could explain these effects. A mutual reduction in retention of either metals was seen when Cu and Zn were applied simultaneousl

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01378.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract —Two vestibulopiasty methods and a muscle‐formed method for improving the retention and stability of complete mandibular dentures were compared in 19 edentulous patients with advanced mandibular bone resorption. The resorptive changes in the alveolar crest and any relapse in the extended vestibule after surgery were monitored for 2 yr. Simultaneous production of the first new complete dentures, to which the labial plate is added during the surgical procedure., and firm circummandibular fixation during primary healing will guarantee the best surgical and prosthetic results.Thisorder of treatment also eliminates unnecessary surgical procedures. A muscle‐formed method for extending the baseplate of a complete mandibular denture was found to be a useful alternative for patients with highly advanced mandibular bone resor

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1986.tb01379.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY