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11. |
Comparison of early onco/suppressor gene expressions in peripheral leukocytes and potential target organs of rats exposed to the carcinogen 1-nitropyrene |
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European Journal of Cancer Prevention,
Volume 9,
Issue 6,
2000,
Page 439-442
I Ember,
I Kiss,
Z Gyöngyi,
Cs Varga,
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摘要:
An in-vivo model has been developed to study early expressions of c-myc, Ha-rasoncogenes andp53suppressor gene as biomarkers of carcinogenic exposure and/or tumorigenesis. In order to validate the in-vivo expression changes as biomarkers, rats were treated with the outdoor air pollutant carcinogen 1-nitropyrene. The gene expression levels were measured after 24 and 48 h in potential target tissues (lung, liver, lymph nodes, kidneys, spleen) and in peripheral blood leukocytes. Another main objective was to prove the applicability of leukocytes as a surrogate tissue, having a similar expression pattern of the selected genes upon carcinogenic exposure. The c-myconcogene was not suitable as an early biomarker because of the lack or low level of its expression. However, in the case of the other oncogene Ha-rasand the suppressor genep53, remarkable and early changes were detected in the expression signals. Similar expression patterns could only be detected in leukocytes and the spleen; therefore we continue this validation study by using other types and routes of exposure.
ISSN:0959-8278
出版商:OVID
年代:2000
数据来源: OVID
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12. |
PRECANCEROUS LESIONS OF THE DIGESTIVE TRACTThe 18th Annual Symposium of the European Cancer Prevention Organisation Maastricht, The Netherlands, 12–14 October 2000 |
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European Journal of Cancer Prevention,
Volume 9,
Issue 6,
2000,
Page 443-463
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PDF (272KB)
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ISSN:0959-8278
出版商:OVID
年代:2000
数据来源: OVID
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13. |
Meat and nutrition, Hamburg: 17–18 October 2000 |
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European Journal of Cancer Prevention,
Volume 9,
Issue 6,
2000,
Page 465-470
M J,
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PDF (119KB)
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ISSN:0959-8278
出版商:OVID
年代:2000
数据来源: OVID
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14. |
Flying amphibians |
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European Journal of Cancer Prevention,
Volume 9,
Issue 6,
2000,
Page 471-472
Lars,
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PDF (97KB)
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ISSN:0959-8278
出版商:OVID
年代:2000
数据来源: OVID
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