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11. |
Egg consumption and risk-markers for colorectal neoplasia |
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European Journal of Cancer Prevention,
Volume 4,
Issue 5,
1995,
Page 425-428
J A Matthew,
I T Johnson,
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摘要:
A strong positive relationship between dietary intake of eggs and risk of colorectal cancer has been observed in a number of epidemiological surveys. In this study we investigated the relationship between egg consumption and intermediate biomarkers of crypt cell proliferation in the colon and rectum of 75 patients who had adenomatous polyps or no evidence of bowel disease. Biopsies of normal flat mucosa were obtained at colonoscopy, and microdissected crypts were used to measure crypt length, frequency of mitosis per crypt and spatial distribution of mitoses within the crypt. There was no significant difference in the consumption of eggs by patients with adenomatous polyps (n=53) and those without (n=22). There was no significant positive correlation between frequency of egg consumption and any of the parameters of crypt cell proliferation in the group as a whole, nor when the patients with polyps were analysed separately. This study provides no biological evidence of any relationship between egg consumption and abnormal cell proliferation among patients at relatively high risk of colorectal neoplasia.
ISSN:0959-8278
出版商:OVID
年代:1995
数据来源: OVID
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12. |
Superoxide dismutase and lipid-bound sialic acid in sera from children with cancers and juvenile chronic arthritis |
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European Journal of Cancer Prevention,
Volume 4,
Issue 5,
1995,
Page 429-435
A Maneva,
D Michailova,
M Sarbenova,
I Christozova,
B Taleva,
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摘要:
Both experimental and epidemiological studies suggest that patients with autoimmune and other chronic inflammatory diseases are more prone to develop cancer. The aim of the present investigation is to find some typical differences between the content of lipid-bound sialic acid (LSA) and the activity of superoxide dismutase (SOD) in sera from children with neoplastic diseases and juvenile chronic arthritis (JCA). Our results show 30% lower SOD activity in the sera from children with cancer compared with the sera from children with JCA. LSA levels 102% and 166% higher than in children with JCA were observed in the sera from children with blood and solid cancers, respectively. The relation LSA/SOD is about fivefold higher in children with cancers. A negative correlation (r=0.720, P<0.001) exists between LSA and SOD in sera from children with cancers. No such correlation was established in the group of children with JCA. We suppose that such differentiation disappears in the beginning of neoplastic process during prolonged therapy of autoimmune diseases. From our findings SOD and LSA appear to be putative markers of malignant disease with potential usefulness not only in JCA but also in other conditions associated with an increased risk of neoplastic development.
ISSN:0959-8278
出版商:OVID
年代:1995
数据来源: OVID
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13. |
Mass screening for colorectal cancer: Statement of the European Group for Colorectal Cancer Screening |
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European Journal of Cancer Prevention,
Volume 4,
Issue 5,
1995,
Page 437-439
J Faivre,
J P Bader,
L Bertario,
S Besbeas,
G Castiglione,
J Chamberlain,
G Dubois,
P Fric,
R Gnauck,
J Hardcastle,
J Kewenter,
O Kronborg,
G Maltoni,
J Wahrendorf,
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PDF (226KB)
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ISSN:0959-8278
出版商:OVID
年代:1995
数据来源: OVID
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