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| 11. |
Congenital hypertrophy of retinal pigment epithelium (CHRPE) as a marker for familial adenomatous polyposis (FAP) |
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European Journal of Cancer Prevention,
Volume 2,
Issue 1,
1993,
Page 69-76
L,
Bertario F,
Bandello C,
Rossetti P,
Sala E,
Fortini P,
Spinelli L,
Gennari M,
Pietroiusti S,
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摘要:
Seventy-eight patients from 26 families were examined to evaluate the potentiality of congenital hypertrophy of retinal pigment epithelium (CHRPE) as a phenotypic marker for familial adenomatous polyposis (FAP). The examined subjects were divided into three different groups: Group I, patients with FAP without extra colonic manifestations (ECM); Group II, patients with FAP and ECM (desmoids/osteomas/upper gastrointestinal adenomas); and Group III, individuals at risk without FAP. Of 24 Group I patients (median age 18 years) 16 had CHRPE compared with 14 out of 24 patients (median age 29 years) in Group II and only three out of 30 patients in Group III. The overall sensitivity of CHRPE for FAP was 70% (±13%) without any difference related to ECM; the predictive value was 92%. The specificity calculated from Group III (median age 26 years) was 90%, but the results should not be considered as definitive because a longer follow-up to determine the appearance of adenomas is required. The data suggest that examination for CHRPE is an inexpensive, non-invasive test for FAP, but the absence of retinal lesions does not eliminate the necessity for adequate follow-up of individuals at risk.
ISSN:0959-8278
出版商:OVID
年代:1993
数据来源: OVID
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| 12. |
Effect of exercise on intestinal tumour development in the male Fischer rat after exposure to azoxymethane |
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European Journal of Cancer Prevention,
Volume 2,
Issue 1,
1993,
Page 77-82
E,
Thorling N,
Jacobsen K,
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摘要:
Thirty-two male Fischer rats were exercised in a treadmill, 2 km daily on weekdays for 38 weeks, after three subcutaneous injections of azoxymethane, 15 mg/kg body weight. Randomly selected control animals were housed in regular 38 ± 22 cm cages in groups of no more than three rats per cage. All rats were allowed free access to food and water. The exercising rats ate about 20% more than the sedentary rats, but gained less weight. Fat stores were considerably smaller in the exercised rats whereas the lean body mass and ash content were similar. After 38 weeks significantly fewer rats in the exercise group had developed neoplasia of the colon mucosa.
ISSN:0959-8278
出版商:OVID
年代:1993
数据来源: OVID
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| 13. |
Supplemental dietary calcium and inhibition of colon cancer |
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European Journal of Cancer Prevention,
Volume 2,
Issue 1,
1993,
Page 83-83
Martin,
Lipkin Harold,
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ISSN:0959-8278
出版商:OVID
年代:1993
数据来源: OVID
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| 14. |
Smoking and adult T‐cell leukemia/lymphoma |
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European Journal of Cancer Prevention,
Volume 2,
Issue 1,
1993,
Page 84-86
&NA;,
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PDF (98KB)
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ISSN:0959-8278
出版商:OVID
年代:1993
数据来源: OVID
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| 15. |
Coping with Cancer and Beyondcancer treatment and mental health |
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European Journal of Cancer Prevention,
Volume 2,
Issue 1,
1993,
Page 87-87
C Caygill,
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PDF (78KB)
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ISSN:0959-8278
出版商:OVID
年代:1993
数据来源: OVID
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