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11. |
Sandalwood oil prevents skin tumour development in CD1 mice |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 449-456
C,
Dwivedi Y,
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摘要:
Sandalwood oil (SW oil) has been used for the treatment of inflammatory and eruptive skin diseases. In the present study, the chemopreventive effects of SW oil on 7,12-dimethylbenz(a)-anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate(TPA)-promoted skin tumour development and TPA-induced ornithine decarboxylase (ODC) activity in CD1 mice were investigated. Female CD1 mice (5–6 weeks old) were divided in different groups, having 30 mice in each group. One week after topical application of DMBA (200 nmole in 100 μ l acetone) alone or with SW oil at different concentrations (100 μl, 1.25, 2.5, 3.75, 5% in acetone), at different times (0.5, 1, 2 h) before DMBA, the mice were treated topically with TPA (5 nmole in 100 μl acetone) alone or with SW oil at different concentrations (100 μl, 1.25, 2.5, 3.75, 5% in acetone) at different times (0.5, 1, 2 h) before TPA applications twice a week for 20 weeks. The mice were weighed and papillomas counted weekly. The results indicate that SW oil pre-treatment decreased the papilloma incidence and multiplicity in a concentration and time-dependent manner. The pre-treatment with 5% SW oil (100 μl) 1 h before DMBA and TPA treatments provided a maximum of 67% and 96% decrease in papilloma incidence and multiplicity, respectively, after 20 weeks of promotion. The mice pre-treated with SW oil at all concentrations and time period before TPA had significantly lower ODC activity than the group treated with TPA alone. The data suggest that SW oil could be an effective chemopreventive agent against chemically-induced skin cancer.
ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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12. |
Perceived risk of cancer in Italy |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 457-460
C,
Vecchia M,
Anelli E,
Zuccato R,
Fanelli F,
Fioretti G,
Sermeus L,
Valdicelli N,
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PDF (195KB)
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ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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13. |
Meat‐cereal ratio and colorectal and breast cancer |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 461-464
C,
Caygill M,
Hill A,
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PDF (206KB)
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ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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14. |
Sugar intake and the risk of colorectal cancer |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 465-468
M,
Hill C,
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PDF (218KB)
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ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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15. |
N-acetylysteine treatment lowers 4‐aminobiphenyl haemoglobin adduct levels in non‐smokers |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 469-472
S,
Rösler J,
Behr E,
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PDF (307KB)
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ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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16. |
A regular contribution from Lars Ovesen, which we hope will help the busy scientist in keeping up with the literature Holy water does not affect the growth of radishes |
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European Journal of Cancer Prevention,
Volume 8,
Issue 5,
1999,
Page 473-473
Lennington,
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PDF (85KB)
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ISSN:0959-8278
出版商:OVID
年代:1999
数据来源: OVID
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