ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Screening for oral cancer is in an early stage of development. No randomized controlled trials have been undertaken to determine the impact of screening on mortality or even on interim outcomes such as incidence or down-staging. Until such data are available, mass screening for oral cancer is not recommended as public health policy. Case finding studies to identify individuals at risk because of life-style, and to detect potentially malignant oral mucosal changes followed by appropriate intervention may, however, reduce the future incidence of oral cancer. Where manpower is available, opportunistic screening focused on high-risk subjects may be beneficial.

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

In a cohort of 25,000 women aged 40–65 years at intake in a periodic screening programme for breast cancer the occurrence of endometrial cancer was studied during a follow-up period of up to 18 years. The authors examined whether they could confirm the existence of a number of relationships between this cancer and some reproductive and anthropometric factors which had been found in several case–control studies and in a few cohort studies. A comparison was made between 147 cases of endometrial cancer occurring during the period of follow-up and a random sample of 900 women taken from the cohort (334 being premenopausal and 566 postmenopausal on the day of intake). An inverse relationship between number of children and endometrial cancer risk was found in the older group; the excess risk among nulliparous women was stronger in married than in single women. Late age at menopause (after age 52) was associated with increased risk. Use of oestrogenic drugs on day of intake for alleviating perimenopausal complaints (reported in 8% of women) increased risk, especially in the younger group. Body weight was positively associated with risk (with an odds ratio of 4 in those over 80 kg) among postmenopausal women. Because there appeared to be a moderately strong risk associated with tall height, especially among postmenopausal women, Quetelet's index performed less well than body weight itself. Nevertheless, subscapular and triceps skinfold thicknesses confirmed an effect of fatness on risk. These results are discussed with reference to other epidemiological studies, in particular two cohort studies from Norway. The effect of height, convincingly shown by Tretli and Magnus in 1990, is explained in a way which does not assume causal mechanisms operating at a young age: absolute fat mass rather than relative weight is regarded as the main determinant of risk in postmenopausal women.

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

A cohort study has been carried out to investigate risk factors for cancer as well as hyperplasia of the endometrium. Over the 13 years for which we followed 25,000 women aged 40–65 (who took part in a population-based screening programme for breast cancer), 111 cases of endometrial cancer and 109 cases of endometrial hyperplasia were diagnosed. A comparison of the outcome between the two disease entities revealed that large body weight among postmenopausal women and the use of oestrogenic drugs at all ages were risk factors for both cancer and hyperplasia of the endometrium. However, reproductive histories and premenopausal steroid profiles differed. Steroid excretion determinations in urine samples collected years before diagnosis provided further evidence in favour of the hypothesis of unopposed action of oestrogens in the aetiology of endometrial cancer. In women who were to develop endometrial hyperplasia or cancer the obesity–oestrogen relationship was stronger than in those who remained free of endometrial disease during the period of follow-up. The possible significance of differences in aromatase activity among the obese is considered.

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Cancer is said to be due to nutrition in 35 cases out of 100, ranging from 10 to 70% by sites. Saturated fats show a positive relationship with cancer, while vitamins, vegetables and cereals show a negative relation with it. This work was aimed at studying the relationship between nutrition and cancer in different Italian areas. Cancer mortality rates collected in 94 National Health units over the period 1980–82 have been correlated with the average food consumption of individuals registered in the same units. All the nutrient groups have shown evidence of a correlation between nutrient intake and mortality rates. Fats, animal proteins and saturated fatty acids showed the strongest positive correlations; vegetable proteins, fibre, carbohydrates, oleic acid, vitamins C and B1 gave negative correlations. Thus, it can be concluded that (a) this ecological analysis has confirmed previous hypotheses concerning the role of vegetables in cancer prevention and (b) the relation between nutrition and cancer mortality could be even stronger if applied to the whole population, since a 1-g increase in vegetable protein consumption would result in a reduction of 2.5 cases out of 100, a 1-g increase in fibre would result in a reduction of four cases out of 100 and a 1-g increase in animal fat would result in an increase of one case out of 100.

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Prevention of cancer mortality can be achieved by two main routes: (1) detection of precancerous lesions and preventing their progression to cancer, and (2) detecting cancers at an early stage when they are still amenable to curative treatment. Early detection of cancer is dependent on the population being well-informed about cancer, and about how to carry out self-examination as a preliminary screen (followed by a full clinical examination in the event of suspicious symptoms). In this paper the warning signs that the population should be taught to look out for are discussed. Superficial observation and palpation can be used for surface tumours (which comprise 10–15% of the total). A further 60–70% of tumours are of the digestive tract, respiratory tract or urogenital tract. For these, it is argued that a simple occult blood test could be used as a self-administered screening test. Data are presented to show that this is a practicable way for the general population to detect early signs of cancer or pre-cancer, with a high yield of clinically significant results in the occult blood positive persons.

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0959-8278    

出版商:OVID    

年代:1996

数据来源: OVID