摘要:

SUMMARY Balances of sodium, potassium, and water were studied in the growing male pig as hypertension developed in response to subcutaneous implantation of deoxycorticosterone acetate (DOCA). Serum sodium, potassium, deoxycorticosterone (DOC), aldosterone, and plasma renln actirity (PRA) were determined. These variables were observed in a total of 10 experimental and nine control pigs. All animals were uninephrectomized and fed a diet of Purina Pig Chow and tap water ad libitum. No salt was added to the food or water. Serum DOC levels rose dramatically on the day of the implantation, then gradually declined but remained approximately 10 times greater than control levels 40 days after Implant.

ISSN:0194-911X    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

SUMMARY Infra-arterial pressure was recorded continuously in 26 patients with uncomplicated essential hypertension under standardized conditions. Recordings were analyzed beat by beat to obtain mean pressures and variability, expressed as tbe standard deflation of the frequency histogram. The major factors influencing variability were tbe level of pressure and tbe Intensity of physical activity; systolic variability increased with progressive impairment of sino-aortic baroreflexes. Diastollc pressure increased with the level of sympathetic activity as reflected by plasma noreplnephrine levels. After allowance for the decrease of plasma renin activity (PRA) with age, direct relationships were observed between PRA (log values) and the level of pressure and systolic variability; plasma angiotensin II values did not correlate. Systolic variability increased with the systolic response to cold but was unrelated to the response to dynamic or isometric exercise. Variability also tended to increase with obesity and was unrelated to age, sex, or race.

ISSN:0194-911X    

出版商:OVID    

年代:1980

数据来源: OVID

ISSN:0194-911X    

出版商:OVID    

年代:1980

数据来源: OVID

ISSN:0194-911X    

出版商:OVID    

年代:1980

数据来源: OVID