摘要:

The effects of a continuous intravenous infusion of prostaglandin E1(PGE1) on mean arterial pressure (MAP), sodium and water balance, and plasma renin activity (PRA) were examined in 10 conscious dogs maintained on a 70 to 75 mEq/day sodium intake. In a crossover pattern, each dog received 6 days of intravenous PGE1(0.1 μg/kg/min) and 6 days of intravenous diluent. When compared to diluent, intravenous PGE1resulted in a mild sustained rise in MAP. By Day 6 the intravenous PGE1, MAP had increased from 98 ± 4 to 112 ± 5 mm Hg (mean ± SE) (p< 0.04). Concurrent with the MAP increase, PRA increased from 0.6 ± 0.2 to 3.1 ± 0.7 ng angiotensin I (AI)/ml/hr (p< 0.03). To assess the role of the renin-angiotensin system in the maintenance of the systemic hypertension, AI converting-enzyme inhibitor was given to four dogs on Day 6 of both intravenous PGE1and diluent. Only when the dogs were receiving PGE1did the administration of convertingenzyme inhibitor result in a significant decrease in MAP (− 19 ± 5 mm Hg). In addition to increasing arterial pressure, the chronic infusion of PGE1also produced changes in salt and water balance. When compared to diluent, PGE1resulted in a twofold increase in both water intake and urine output, an increase in urinary sodium excretion (from 72 ± 3 to 84 ± 6 mEq/day,p< 0.05, on Day 1), and a decrease in urine osmolality (from 942 ± 82 to 586 ± 61 mOsmol/kg H2O/day,p< 0.05, on Day 1). We conclude that, in the dog, a 6-day intravenous infusion of PGE1results in rerun-supported hypertension and increased water intake, urine output, and urinary sodium excretion.

ISSN:0194-911X    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

The effects of decaffeinated green tea on CBA mice have been contrasted with those of water during 3 to 5 months of exposure to various intensities of social stress. Intensity was modified by using different types of caging: Henry-Stephens complex population cages for maximum stress, open field population cages for intermediate levels, and siblings in standard mouse boxes for minimal stress. Two population densities were used: high, with 16 males and 16 females per population cage; and low, with approximately half this number. In three sets of experiments, 58 comparisons were made between body weight, blood pressure, pulse rate, scarring, blood urea nitrogen (BUN), adrenal and heart weights, plasma corticosterone, adult male mortality, and number of weanlings of those on decaffeinated green tea and matched groups on water. Twenty-five of the comparisons indicated less arousal with the decaffeinated green tea and in none was the water favored. Blood pressure fell from 150 to 133 mm Hg. These results support the proposal that the polyphenols (bioflavonoids) of tea may have a beneficial sedative action.

ISSN:0194-911X    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0194-911X    

出版商:OVID    

年代:1984

数据来源: OVID