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1. |
Changes in Wave Reflection With Advancing Age in Normal SubjectsResponse |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 10-11
Gary Mitchell,
Helen Parise,
Emelia Benjamin,
Martin Larson,
Michelle Keyes,
Joseph Vita,
Ramachandran Vasan,
Daniel Levy,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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2. |
Roles of the Renal Kallikrein-Kinin System in Salt-Sensitive HypertensionResponse |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 12-12
Daniel Jones,
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PDF (28KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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3. |
Back to the Basic: Measuring QRS Voltage-Interval in Left Ventricular Hypertrophy |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 13-13
Antonio Delgado-Almeida,
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PDF (31KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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4. |
Hormone Replacement Therapy and Cardiovascular DiseaseWhat Went Wrong and Where Do We Go From Here? |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 789-795
Raghvendra Dubey,
Bruno Imthurn,
Lefteris Zacharia,
Edwin Jackson,
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PDF (74KB)
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摘要:
Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone’s astonishment, the Women’s Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?
ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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5. |
Hypertension and RhoA/Rho-Kinase Signaling in the VasculatureHighlights From the Recent Literature |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 796-799
Dexter Lee,
R Webb,
Liming Jin,
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PDF (54KB)
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摘要:
Under normal conditions, contractile activity in vascular smooth muscle is initiated by either receptor activation (norepinephrine, angiotensin II, etc.) or by a stretch-activated mechanism. After this activation, several signaling pathways can initiate a Ca2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase thereby maintaining force generation. In opposition to force generation, NO is released from endothelial cells and causes vasodilation through inhibition of the RhoA/Rho-kinase signaling pathway. This brief review will highlight recent studies demonstrating a role for the RhoA/Rho-kinase signaling pathway in the increased vasoconstriction characteristic of hypertension.
ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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6. |
Management of Hypertension in the Very Elderly Patient |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 800-804
William Elliott,
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PDF (171KB)
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摘要:
This Hypertension Grand Rounds discusses pharmacological treatment of hypertension in individuals who have survived 9 decades on earth. This rapidly growing group of relatively active and healthy elderly people is at high risk for hypertension, its treatment, and its adverse consequences, including stroke and heart failure. In this age group, the most common abnormality is elevated systolic blood pressure, which is much more predictive of stroke and heart disease death after 53 years of age. With the possible exception of the Antihypertensive and Lipid Lowering to prevent Heart Attack Trial (ALLHAT), recent clinical trials have emphasized the overriding importance of lowering blood pressure rather than the specific agent chosen to begin therapy. In 1999, a metaanalysis of 7 clinical trials that enrolled 1670 subjects >80 years of age indicated that active antihypertensive drug therapy significantly reduced stroke by 34% and heart failure by 39% but was associated with a nonsignificant 6% increase in mortality. The HYpertension in the Very Elderly Trial (HYVET) will enroll 2100 patients >80 years of age and will compare 2 groups randomized to indapamide±perindopril versus placebo±placebo for incident stroke during 5 years of follow-up. This study should answer lingering questions about whether active antihypertensive therapy is associated with a major and significant reduction in cardiovascular morbidity and mortality in this age group as it clearly does in younger hypertensives. Its choice of a diuretic as initial therapy is consistent with other trials, but chlorthalidone is the drug with the most compelling evidence in large US trials that included very elderly patients.
ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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7. |
Alcohol-Associated HypertensionWhen One Drinks Makes a Difference |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 805-806
Arthur Klatsky,
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PDF (37KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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8. |
Blunted Decline in Systolic Blood Pressure After Exercise Predicts Future Acute Myocardial Infarction |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 807-808
John Madias,
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PDF (35KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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9. |
Osteopontin: A Protective Mediator of Cardiac Fibrosis? |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 809-810
Kristof Graf,
Philipp Stawowy,
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PDF (38KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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10. |
Fetal and Early Life Determinants of Hypertension in AdultsImplications for Study |
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Hypertension,
Volume 44,
Issue 6,
2004,
Page 811-812
Daniel Lackland,
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PDF (33KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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