摘要:

Nonhuman animal research is advantageous only if the ethical dilemma surrounding the use of live animals for this purpose is resolved in one's laboratory and institution. Investigators have struggled in creating an animal model of the disease that realistically mimics the natural course of the disease in humans. It has been exceptionally difficult to develop a model that proves capable of progressing to the end-stage condition of frank mechanical collapse that occurs in humans. This paper attempts to describe the significant findings of various animal models, their advantages and disadvantages, and their key methodologies that could assist in the development of that elusive ideal model.

ISSN:0885-9698    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Many techniques exist for the performance of core decompression of the femoral head, and many surgeons have reported good results with a variety of techniques. The technique described here uses equipment available to all orthopaedic surgeons. Using a guide pin for initial placement, the position of the core tract can be precisely controlled and its placement can be optimized.

ISSN:0885-9698    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The treatment of osteonecrosis of the femoral head is considerably more successful at early stages of the disease, therefore, the diagnosis of osteonecrosis at an early stage is critical for hip preservation. The early diagnosis of osteonecrosis, in turn, depends upon the identification of individuals at risk. Understanding the pathogenic factors leading to osteonecrosis enables the early investigation of at-risk individuals and facilitates prompt diagnosis. The most likely final pathogenic pathway for nontraumatic osteonecrosis involves intravascular coagulation and microcirculatory thrombotic occlusion. Efforts are being made to identify individuals with a heritable tendency to intravascular coagulation who may be at risk for osteonecrosis.

ISSN:0885-9698    

出版商:OVID    

年代:2001

数据来源: OVID