ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03134.x

年代:1991

数据来源: WILEY

摘要:

AbstractCell cultures of excised keloids and biopsied normal skin were established from patients of the Plastic Surgery Department of Singapore General Hospital and their single cells quantitated for glucose‐6‐phosphate dehydrogenase (G6PDH) activity using microspectrophometry. G6PDH has been cited as a transformation‐linked discriminant. Analysis of variance shows no difference in overall activity between skin and keloid cells, but under oxygen saturation conditions, keloid G6PDH activity was significantly higher than skin G6PDH activity, although they were almost identical under nitrogen saturation conditions. Differential oxygen sensitivity in G6PDH activities between malignant and non‐malignant cells have been reported, but its occurrence between keloid and normal skin cells is novel, especially as the keloid is regarded as a benign tumor with a zero carcinogenici

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03135.x

年代:1991

数据来源: WILEY

摘要:

AbstractWe have compared the clinical and histopathological features of 6 patients with lymphomatoid papulosis (LP) and 14 patients with pityriasis lichenoides et varioliformis acuta (PLEVA). There were some differences between the clinical features in the two diseases, including the size and appearance of skin lesions and the duration of the course of disease. Ki‐1 Ag positive, large, atypical, lymphoid cells were always seen in lymphomatoid papulosis; none of lymphoid cells of pityriasis lichenoides et varioliformis acuta demonstrated this antigen. We conclude that lymphomatoid papulosis and PLEVA, although sharing some common features, should be considered to be different clinical and immunopathological entitie

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03136.x

年代:1991

数据来源: WILEY

摘要:

AbstractA panel of monoclonal antibodies (Leucocyte Common Antigen [CD45], LN‐1 [CDw75], LN‐2 [CD74], LN‐3, L‐26, UCHL‐1 [CD45RO]and MT‐1) which identify B and T cell surface markers were applied to benign lymphocytoma cutis and malignant lymphoma of the skin in paraffin‐embedded sections.In five cases of lymphocytoma cutis, both B and T cell markers were positive, consistent with the polyclonality of the proliferative lymphocytes. In contrast, in two cases of B cell lymphoma, only the B cell markers were positive, consistent with the monoclonality.Furthermore, the immunohistochemistry clarified lymph follicle structures of lymphocytoma cutis. These were occasionally not evident in routine hematoxylin and eosin stained sections.Thus an immunologic phenotyping study combined with other appropriate criteria for histologic evaluation and clonal gene rearrangement analysis appears to be useful in distinguishing reactive from neoplastic lymphoid lesion

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03137.x

年代:1991

数据来源: WILEY

摘要:

AbstractThirty‐six cases of cutaneous malignant melanoma with histologically involved lymph nodes were studied during a 2–10 year study period, and the characteristics of the metastasized nodes and the associated prognosis were compared. The results were as follows: 1) the survival rate in cases with 3 or fewer (n=16) metastasized nodes was significantly higher than in cases with 4 or more positive nodes (n=20); 2) the survival rate in cases in which metastasized nodes were limited to one regional lymph node section (n=12) was significantly higher than in cases where metastasis extended to two or more intra‐regional sections of nodes (n=24); 3) cases which had nodes measuring 3.00 cm or less (n=25) had significantly higher survival rates than those with nodes of 3.01 cm or more (n=11). Therefore, the results indicate that the number of metastasized lymph nodes, the extension into regional lymph node sections, and the size of the metastasized lymph node(s) can be considered as important prognostic factors for melanoma pat

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03138.x

年代:1991

数据来源: WILEY

摘要:

AbstractWe describe here a case of EMO syndrome, which is defined as a combination of exophthalmos, pretibial or localized myxedema, and hypertrophic osteoarthropathy. A 34‐year‐old Japanese man with Graves' disease developed the characteristic eye changes. He showed 22 mm protrusion of both eyes and hypertrophy of the right lateral rectus muscle as well as both superior rectus muscles by computerized tomography. He subsequently developed lightly erythematous, indurated, nonpitting, peau d'orange plaques and nodules on his lower legs. Finally, he developed Graves' acropathy with hypertrophic osteoarthropathy in the metacarpal bones. Histological examination of myxedematous skin showed typical deposition of mucin accompanied by changes in the amount and distribution of elastic fibers. In addition, the lesional skin showed localized hyperhidrosis, a rarely reported complication of pretibial myxedema. We speculate that this hyperhidrosis of the lesional skin was brought about by stimulation of peripheral sympathetic nerves by surrounding mucin deposition, in the setting of poorly controlled hyperthyroid

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03139.x

年代:1991

数据来源: WILEY

摘要:

AbstractTransepidermal elimination (TEE) is a well known phenomenon by which foreign or altered constituents are removed from the dermis. A thrombosis in the dilated dermal blood vessels of angiokeratoma is not unusual, hence the term thrombotic angiokeratoma.We recently reviewed the histopathologic findings of previously diagnosed cases of angiokeratoma and found that multiple histologic sections of surgical biopsy materials disclosed changes indicating TEE of thrombi in three cases. Special stains searching for an altered substance in those thrombi failed.In this report of three cases, we suggest that this phenomenon could be an incidental and long missed histopathologic finding of angiokeratoma which might explain the fate of these thrombi.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03140.x

年代:1991

数据来源: WILEY

摘要:

AbstractA case of erythropoietic protoporphyria (EPP) with severe acute abdominal pain and jaundice was reported. Erythrocyte protoporphyrin (PP) levels were constantly high, and liver histology showed a slight fibrosis with inflammatory infiltation. During the investigation period of 18 months, erythrocyte PP levels closely paralleled those of serum γ‐G

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03141.x

年代:1991

数据来源: WILEY

摘要:

AbstractThree Japanese patients with trigeminal trophic syndrome, a rare dermatosis in Japan, were reported. Cutaneous lesions were a long‐standing ulcer and destruction of the right ala nasi in case 1, a persistent deep ulceration on the forehead after a small trauma in case 2, and development of small, discrete ulcers on the right forehead during the treatment of a postherpetic neuralgia in case 3. A protective device was very effective in one patien

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03142.x

年代:1991

数据来源: WILEY

摘要:

AbstractA 6‐year‐old girl with Down's syndrome presented milialike whitish small papules on her hands and feet and periorbital syringoma. Histopathological examination of the hand lesion revealed small localized calcium deposits and syringoma in the adjacent upper dermis. This is a very rare but typical case of calcinosis cutis with syringoma in a patient with Down's syndr

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03143.x

年代:1991

数据来源: WILEY