ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01902.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTA statistical survey of 100 cases of sporotrichosis at the Dermatological Clinic of Chiba University Hospital from May, 1965 to June, 1975 was reported. The proportion of sporotrichosis cases to the total number of outpatients and to the total dermatomycoses was 0.14% and 1.8%. It has increased gradually since 1969. Greater percentage of cases fell into the less than 11 year old or more than 40 year old age groups. Females were more affected than males. Half of the cases occured in farmers. Geographic distribution was remarkable. 44 cases had a history of injury. 62 cases showed the cutaneous lymphatic type and 38 cases showed the localized cutaneous type. The face and upper extremities were the most affected. The sporotrichin test was positive in 41 of 42 cases. The causative organism was demonstrated in tissue sections in 97 of 99 cases.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01903.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe relation between cellular differentiation and associated cytomorphogenesis and secretion in pigment cells was studied by using scanning and transmission electron microscopes. Cytomorphogenesis and the related transfer of melanosomes was compared in epidermal melanocytes of guniea pigs and melanoma cells of mice grown in culture.Scanning electron microscopic studies showed that melanocytes and melanoma cells have a different surface structure, which is modified according to cellular differentiation. The melanocytes and their dendrites possess poorly developed villous pods or microvillies. The dendrites secrete melanosomes extracellularly in the vicinity or on the surface of keratinocytes. Melanoma cells, on the other hand, reveal well developed villous pods which are often directly attached to the surface of the dish. Thus villous pods do not appear to play any part in the melanosome transfer. Also, the melanoma cells do not transfer melanosomes as often as do the melanocytes. Furthermore melanosomes are transferred to keratinocytes after being secreted extracellularly.Transmission electron microscopy indicated that the melanocytes and melanoma cells contain 5 nm filaments responsible for anchoring the cells to the dishin vitro. Epidermal melanocytes also contain numerous 10 nm filaments that are motile organelle and induce a motive force for melanosome transfer.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01904.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe clinical significance and correlation of antinuclear antibodies (ANA) and anti‐DNA antibodies was studied using 142 ANA positive sera from different patients having various diseases. High titers of ANA were found briefly in systemic lupus erythematosus and sometimes in scleroderma or mixed connective tissue disease. The peripheral pattern of ANA was seen exclusively in systemic lupus erythematosus and occasionally in mixed connective tissue disease. Anti‐DNA antibodies could be found in systemic lupus erythematosus, discoid lupus erythematosus, scleroderma, chronic active hepatitis, but a high titer of anti‐DNA (over 60 unit/ml) was present only in patients with systemic lupus erythematosus, especially those having lupus nephritis. There was little correlation between ANA and anti‐DNA ant

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01905.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTFITC‐labeled staphylococcal protein A was used to detect pemphigus antibodies. The results showed that protein A was specific in the systems tested, although it was not as sensitive as FITC‐anti IgG in indirect immunofluorescence tests. Protein A‐adsorbent was used to isolate IgG from pemphigus serum samples. Recovery of pemphigus antibody activity was a mean of 57.1 percent, as high as that of DEAE chromatography. We consider protein A to be an alternative to monospecific anti IgG for detection of pemphigus antibodies and for purification of IgG from pemphigus

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01906.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTLarge molecular weight sodium dextran sulfate (SDS) injection into the dermis of both normolipemic rabbits and hypercholesterolemic rabbits induced infiltration of histiocytes and foam cells. Sudan III staining showed that the histiocytes and foam cells of hypercholesterolemic rabbits accumulated lipids similarly to xanthoma foam cells. The accumulated lipids increased as the injection was repeated at the same site. However, the lipid accumulation was minimal in the histiocytes of normolipemic rabbits. As determined by quantitative analysis of lipid composition in the lesions of hypercholesterolemic rabbits, cholesterol esters remarkably increased concomitantly with injection frequency. Free cholesterol accumulation was less pronounced than cholesterol ester. In normolipemic rabbit dermis, accumulation of free cholesterol was insignificant and cholesterol esters did not accumulate progressively with repeated SDS injections. Apparently the foam cells of hypercholesterolemic rabbits actively incorporated serum low density lipoproteins (LDL) and cholesterol was esterified in the foam cells. On the other hand, LDL were minimally incorporated into histiocytes in the normolipemic state. The intradermal SDS injection is a beneficial experimental model for further investigations on the mechanisms of lipid accumulation and the intracytoplasmic lipid metabolism of xanthoma foam cells.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01907.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe relationship of cyclic AMP to epidermal cell division has been studied in cultured guinea pig epidermal cells. Tritiated thymidine uptake by cultured cells reached a peak the second day after seeding. A significant drop in the concentration of cyclic AMP occurred simultaneously with the increased uptake of tritiated thymidine into DNA. Those cells in which the concentration of cyclic AMP decreased did not respond to external prostaglandin E1(PGE1) stimulation. The response was restored in the cultured cells on the fourth and fifth when intracellular concentration of cyclic AMP started to rise. The results indicate that there is a cyclic alteration of the surface membrane of epidermal cells during active DNA synthesis which may be related to fluctuation in the intracellular concentration of cyclic AMP.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01908.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTSebaceous gland carcinoma (SGC), basal cell epithelioma with sebaceous cell differentiation (BCE+S) and basal cell epithelioma (BCE) were examined enzymatically, in order to elucidate the enzymatic characteristics of these tumors and the tumor cell origin of BCE+S.SGC demonstrated significantly higher enzyme activity of glucose‐6‐phosphate dehydrogenase (G‐6‐PDH), isocitrate dehydrogenase (ICDH) andα‐glycerophosphate dehydrogenase (Gly‐PDH) than did BCE.BCE+S had an enzymatic pattern similar to BCE, except for Gly‐PDH which resembled SGC.The results obtained in this study indicated that BCE+S derived not from sebaceous gland cells but from primitive basal cells or epidermal cells which transformed into BCE and then partially differentiated toward sebaceo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01909.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTHLA‐C typing was performed on 40 unrelated Japanese patients with psoriasis vulgaris. The patient group consisted of 22 patients who had psoriatic HLA antigens i.e., B13 in seven cases, B17 in one case and B37 in 14 cases; and 18 patients who had none of these specific HLA antigens. HLA‐C typing was also performed on 40 unrelated healthy Japanese controls. Cw6 was found in 55.0% of the patients as compared with 5.0% of the healthy controls. All patients (21 cases) who had either B13 or B37 were positive for Cw6. Both controls who were positive for Cw6 also had B37. These results suggest the possibility of a linkage disequilibrium between Cw6 from locus C and B13 and B37 from locus B, and/or an association between Cw6 and susceptibility to psoria

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01910.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01911.x

年代:1979

数据来源: WILEY