ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02570.x

年代:1981

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02571.x

年代:1981

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02556.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTA case of a 77‐year‐old woman with metastatic melanoma and vitiligo‐like leukoderma is reported. The primary lesion had been excised 8 years previously. It had the histologic features of amelanotic melanoma. Metastatic lesions were also amelanotic. Vitiligo‐like leukoderma was noted distant from the cutaneous tumors. The tumors were responsive to a combined regimen of DTIC, ACNU and vincristine and became pigmented after treatment. The relationship between the development of melanized melanoma and chemotherapy is di

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02557.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTMycosis fungoides, lymphosarcoma of a T cell nature with cutaneous involvement, and malignant histiocytosis with primary skin manifestation were presented and their cutaneous lesions were examined with particular emphasis on localization and cytological features of the tumor cells. In addition, six autopsy cases of systemic lymphosarcoma involving the skin and one autopsy case of malignant histiocytosis which showed cutaneous dissemination were reviewed, and a comparative study of the cutaneous lesions of those cases was performed. It was noted that lymphosarcomas tended to infiltrate the lower dermis and underlying subcutaneous tissue, retaining the cell types of tumor cells seen in the primary sites. In malignant histiocytosis, it was suggested that eosinophilia and eosinophilic infiltration in the tissue might indicate longer survival.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02558.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTThe glycosaminoglycan (GAG) contents of the cutaneous papules, the non‐eruptive skin, and the urine of a patient with Hunter syndrome were examined. Both skin samples contained hyaluronic acid (HA) and dermatan sulfate (DS) as major components and heparan sulfate (HS) and chondroitin sulfate (CS) as minor components. The HA content of the papules was greatly increased, while that of the non‐eruptive skin was normal. The amounts of DS and HS were increased in all three samples; the papules, non‐eruptive skin, and urine. HS from the patient's skin and urine had an electrophoretic mobility different from that of authentic HS. It seemed interesting from a pathogenetic viewpoint that the components of GAG in the cutaneous papules differed from those in the non‐eruptive skin an

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02559.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTThis study was designed to investigate the influence of d‐α‐tocopheryl acetate on the toxic effect of retinoic acid and retinoid (Ro 10‐9359) on pancreaticobiliary and gastric secretion after the administration of large doses for 3 weeks to albino rats.The toxicity of retinoic acid on body weight and exocrine function, and the morphologic changes in the main digestive glands of the rat are greater than with retinoid.It is clear that vitamin E may suppress or counteract the undesirable toxic effects of retinoic acid and retinoid and appears to promote the function of the main digestive glands o

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02560.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTIn order to clarify the site(s) from which steatocystoma multiplex (SCM) originates, five cases of SCM and the normal pilosebaceous apparatus were comparatively examined by electron microscopy. The cyst‐wall of SCM, consisting either of flattened or of undulating horny layer, contained a small number of tonofilaments, desmosomes, and tiny spherical keratohyalin granules. There were variable numbers of lamellar granules which were also frequently observed in the intercellular spaces of the horny layer. Three of the SCM cases included sebaceous cells. The contents of the cysts were mostly amorphous and short‐fibrillar, but sometimes keratinized cells and remnants of lamellar granules were observed. These findings were analogous to those of the normal pilosebaceous apparatus from the level of the lower part of the infundibulum to the outer root sheathViathe sebaceous duct, and were specifically more analogous to those of the sebaceous d

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02561.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTA 54‐year‐old Japanese male with Werner's syndrome was reported. We found increased excretion of hyaluronic acid in the urine, although the content and analyses of the glycosaminoglycans in the urine eluted by Dowex‐1 column chromatography was shown to be hyaluronic acid by comparison with standard hyaluronic acid. The Sephadex G‐200 gel filtration of the 0.5 M NaCl fraction caused separation into two fractions. It was revealed that there was not only an excessive production of hyaluronic acid, but also an excretion of lower molecular weight hyaluronic acid in the urine of this s

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02562.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTUsing an immunofluorescence technique, we investigated lesions of drug‐induced lichen planus‐like lesions from patients. In addition, a comparative study of idiopathic lichen planus from thirteen patients was made.Deposits of fibrinogen along the epidermal basement zone, IgM, and less often IgA, IgG, C1q and C3 on the colloid bodies were found in drug‐induced lichen planus‐like lesions. Similar deposits of immunoglobulins and complements were noted in 2 of 3 lesions developed by successful provocation tests. Deposits of fibrinogen were also demonstrated in all 3 lesions. However, no circulating antibodies directed toward the epidermal basement zone or other skin components were detected. No elevation of circulating immune complex levels was noted.Immunofluorescence findings in drug‐induced lichen planus‐like lesions were essentially identical to those in idiopathic lichen planus. This indicates that both conditions share a common dise

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02563.x

年代:1981

数据来源: WILEY