ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03272.x

年代:1994

数据来源: WILEY

摘要:

AbstractBackgroundSince 1987, many cases have been reported in which human papillomavirus (HPV) could be associated with epidermoid cysts of the palms and soles. In 1989, the HPV found in an induced epidermoid cyst was cloned and named HPV 60.ObjectiveOur purpose was to examine the relationship of HPV 60 to plantar cysts.MethodsTen cases of plantar cysts and two cases of verruca plantaris containing single inclusion bodies were obtained by biopsy and examined by thein situhybridization (ISH) method with a digoxigenin labeled HPV 60 DNA probe.ResultsSix of ten cases were found to have cytopathic effect (CPE) in the cyst wall and inner contents of the cyst. HPV 60 was detected in these cases by ISH. Two cases of verruca plantaris showing CPE also demonstrated the presence of HPV 60. Of the six HPV type 60 positive cases, four cases also showed CPE in the overlying epidermis.ConclusionAt first, punctate keratotic lesions are induced by HPV 60. HPV 60 induces irregular elongation of the rete ridges into the dermis. Plantar cysts probably form as a result of the traumatic implantation of HPV 60 infected epidermis with irregularly long and narrow rete ridges into the dermis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03273.x

年代:1994

数据来源: WILEY

摘要:

AbstractInterferon‐γ (IFN‐γ) has been shown to induce or enhance the expression of MHC class II and intercellular adhesion molecule‐1 (ICAM‐1) in a variety of human and murine cell types, including epidermal keratinocytes (KC). However, the expression of MHC class II and ICAM‐1 molecules induced by IFN‐γ is not necessarily coordinated. We investigated the inhibitory effects of the calmodulin antagonist, W‐7, and its chlorine deficient inactive analogue, W‐5, on the expression of MHC class II (HLA‐DR) and ICAM‐1 by human KC incubated with IFN‐γ. We found that the IFN‐γ‐induced expression of HLA‐DR was reproducibly and dose‐dependently inhibited by W‐7. However, the expression of ICAM‐1 was highly resistant to the inhibitory effects of W‐7. Neither HLA‐DR nor ICAM‐1 expression was affected by W‐5. These data suggest that the IFN‐γ‐induced HLA‐DR, but not ICAM‐1, expression is

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03274.x

年代:1994

数据来源: WILEY

摘要:

AbstractImmunopathologic aspects of bullous skin diseases were studied in paraffin sections of thirty‐three skin biopsy specimens utilizing monoclonal antibodies directed against histiocytes, helper/inducer T lymphocytes, and Langerhans cells in skin lesions. Laboratory examinations revealed that either more or fewer of the standard number of helper/inducer T lymphocytes (UCHL1+) were observed in the upper dermis in 84.8% of the cases examined, particularly in the various forms of pemphigus; histiocytes (MAC387+) were also found to occur in the upper dermis in 45.5% of the cases and in blisters in 27.3% of the cases, particularly in pemphigus erythematosus and dermatitis herpetifomis. In 54.5% of all the cases, both UCHL1+ and MAC387+ cell infiltrates predominated in the upper dermis. These findings suggest that a cell‐mediated immune response may also be important in the pathogenesis of bullous skin diseases. It may be possible that antigen from keratinocytes can produce ETAF, and that IL1 activating T lymphocytes and histiocytes also produce IL1 activating T cells, particularly helper/inducer T cells. Such activities would further promote the increase of B cell function and immunoglobulin synthe

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03275.x

年代:1994

数据来源: WILEY

摘要:

AbstractVitiligo is frequently associated with segmental involvement. It spares paralyzed limbs in transverse myelitis. There is spontaneous repigmentation of vitiligo lesional skin (VL) in diabetic neuropathy. Increased neuropeptide in VL and adjacent normal skin of vitiligo (ANS) along with thickened nerve fibers showing ultrastructural abnormalities all indicate a neural pathogenesis (1). Loss of Merkel cells has been observed in early vitiligo lesional skin (2). Recently, catecholamines have been found to play a major role in initiating the cascade of events leading to loss of melanocytes (1, 3, 4).To investigate the presence of Merkel cells in the completely depigmented skin of stable vitiligo (SV), a study was undertaken using TROMA 1, a monoclonal antibody specific for adult Merkel cells. No TROMA 1‐positive cells were observed in SV, whereas normal numbers of these cells were seen in ANS. This new finding further supports the hypothesis of neural involvement in vitilig

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03276.x

年代:1994

数据来源: WILEY

摘要:

AbstractTwenty patients with nodulocystic acne were randomly allocated to one of two treatment schedules: 1) Tetracycline 500 mg or 2) Tab. Gugulipid (equivalent to 25 mg guggulsterone). Both were taken twice daily for 3 months, and both produced a progressive reduction in the lesions in the majority of patients. With tetracycline, the percentage reduction in the inflammatory lesions was 65.2% as compared to 68% with gugulipid; on comparison, this difference was statistically insignificant (P>0.05). Follow‐up at 3 months showed a relapse in 4 cases on tetracyline and 2 cases on gugulipid. An interesting observation was that the patients with oily faces responded remarkably better to gugulipi

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03277.x

年代:1994

数据来源: WILEY

摘要:

AbstractWe observed transient, erythematous skin eruptions in 6 patients during the intravenous administration of interferon (INF)‐α for chronic active hepatitis C. The eruptions appeared 5 to 14 days (mean: 6.8 days) after initiating its administration. They were localized or disseminated and consisted of edematous, erythematous, and/or papular changes. Vesicles and petechiae also appeared in some cases. The eruptions disappeared in 10 to 14 days, despite the continuance of INF‐α and without specific treatment.Histological examination obtained from skin eruptions revealed perivascular infiltration of lymphoid cells, the majority which were CD4‐positive, of the upper dermis. Edematous changes were present in the papillary dermis. Vascular endothelial cells in the upper dermis expressed both intercellular adhesion molecule‐1 (ICAM‐1) and endothelial leukocyte adhesion molecule‐1 (ELAM‐1), while the epidermal keratinocytes produced neither. These findings suggested a nonallergic mechanism for

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03278.x

年代:1994

数据来源: WILEY

摘要:

AbstractBasal cell carcinomas (BCCs) of the lower extremities are not frequently reported. Some pre‐existing or predisposing conditions are thought to be implicated in their development. In this study, we investigated the possible relationships between pre‐existing cutaneous changes and the development of BCCs of the lower extremities, possible sex and age differences, and the histologic patterns involved. Among 1053 patients with BSSc, BCCs of the lower extremities were observed in 48 (4.5%): 25 men and 23 women. Lesions appeared on the thighs (16 cases), the lower legs (27 cases), or the feet (5 cases). Histologic patterns were nodular and micronodular (18 cases), superficial (27 cases), or infiltrative (3 cases). No differences were observed between sexes. The relative degree of elastosis was higher in the lower limbs of women than of men (2.25vs1.53).Pre‐existing cutaneous changes were observed in 7 cases. The frequency of these BCCs of the lower limbs and the higher degree of elastosis observed in the women seem to be related to sun exposure. The histologic pattern seems not to be affected by environmental factors but rather characteristic of body site. Pre‐existent cutaneous changes are not thought to be possible etiologic

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03279.x

年代:1994

数据来源: WILEY

摘要:

AbstractMeasles skin rash was immunohistochemically examined in an effort to detect virus antigen in skin samples taken from a 15‐year‐old girl with measles. A sectioned specimen obtained by punch biopsy from a 2nd‐day skin lesion showed localized parakeratosis and acanthosis with multinucleated giant cells in the epidermis, thickening and cellular edema of epithelia in the hair follicles, and vascular dilatation in the papillary plexus. Measles virus antigen was detected by ABC immunoperoxidase in the epidermis, follicular epithelia, and lympho‐histiocytic cell infiltrates in the upper part of the dermis. This rash was deemed to be caused in part by direct viral infection of the epiderma

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03280.x

年代:1994

数据来源: WILEY

摘要:

AbstractSpindle cell squamous carcinoma (SCSC) of the left hand arising in a patient with longstanding erythroderma is reported. Histopathologically, spindle shaped atypical cells were observed neighboring the cells of well differentiated squamous cell carcinoma. These two types of tumor cells, spindle cells and well differentiated cells, were present side by side and merged into each other. The erythroderma had been present for over 20 years, and both clinical and histopathological findings suggested cutaneous T cell lymphoma, but were not diagnostic for mycosis fungoides, Sézary syndrome, or adult T cell lymphoma. Flow cytometry of peripheral blood cells showed a low CD4/CD8 ratio which suggested impaired T cell function. Multiple metastases of SCSC occurred in a short period and the patient died ten months after his first visit to us. The aggressive course of this case was unusual, and may be due to immunological abnormalities associated with the long standing erythroderma with impaired T cell function

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb03281.x

年代:1994

数据来源: WILEY