摘要:

ABSTRACTTwo hundred and eighty five cases of pustulosis palmaris et plantaris (PPP), of which 73 cases (25.6%) underwent tonsillectomy, were studied to evaluate the effectiveness of tonsillectomy as a treatment for PPP. The group of tonsillectomized patients showed significantly better results than a group which received other methods of treatment. A tendency to leukocytosis was observed in PPP which normalized, in many cases, after tonsillectomy. The shorter the period between the onset of PPP and tonsillectomy the better the results, and the quicker the response. A transient worsening of PPP after tonsillectomy did not after the prognosis.In order to determine if tonsillectomy was indicated, an ultrashort wave direct provocation test was conducted in which ultrashort wave was applied to the tonsil. Leukocytosis and worsening of PPP after the test was considered as an indication for tonsillectomy. In some cases, there were considerable changes in plasma Cortisol levels and NBT test values after the provocation test.Improvement of PPP after the Impretol test (one of the annulation tests) in which Impretol was injected into the tonsil, appears to support the focal infection origin of PPP in these cases. There is a possibility that the Impretol test could be used as a treatment for PPP.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01033.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTImmunoglobulin M and complement (Clq, C3 and C9) were found to be deposited together in the walls of affected blood vessels and also in the basement membrane zone of skin lesions from two patients with pityriasis lichenoides et varioliformis acuta (PLVA). The fluorescence appeared to be most intensely distributed in blood vessels which were affected by inflammatory infiltrates and frequently showed hyaline or fibrinoid changes of their walls. Deposits of C3 activator, fibrin and albumin were not observed. These findings suggest that the disease process in PLVA is the result of a vasculitis mediated by an immune complex and possibly by activation of the classical complement pathway.In addition, serum IgM was slightly increased in both patients.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01034.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn order to elucidate both the mechanism of deposition and the composition of the substance that is observed mainly the intercellular spaces (ICS) and to a lesser extent in the cytoplasm of psoriatic epidermis, five cases of psoriasis vulgaris were examined using conventional histology and histochemistry, electron microscopy, and direct immunofluorescence technique with or without incubation in acid citrate buffer or digestion by fibrinolysin. The substance was found by electron microscopy to be rather dense and finely granular, and that in the parakeratotic horny layer was diastase‐resistant PAS positive, and showed positive immunofluorescence for immunoglobulins, complement, and fibrinogen. The fluorescence was not significantly altered by preincubation of the tissue sections in acid citrate buffer, but was significantly diminished by predigestion of tissue sections with fibrinolysin. From these findings, we concluded that the substance is likely to consist of and be derived from the components of plasma protein, and to play a role in the formation of the parakeratotic psoriatic horny layer. It also seems that the deposition of this substance is rather the result of the coagulation of plasma protein than that of antigen‐antibody reacti

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01035.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTAn acute streptococcal infection is well‐known to be a predisposing factor in acute guttate psoriasis. This study also revealed a high ASO titer in 11 of 13 patients at first examination. However, a non‐specific ASO increase due to non‐immunological reaction of serum lipoproteins with antistreptolysin‐O, was found in 5 of these patients who visited our clinic at the evolving phase, 2 or 3 weeks after onset of the eruption but was no longer observed at 5–6 weeks and thereafter. On the other hand, specific ASO increase, which was not related to lipoproteins, was observed first in some patients at 3–4 weeks and at 7–10 weeks in all patients examined. These observations suggest the role of streptococcal lipoprotein alteration in the occurrence of

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01036.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTForty‐nine strains of anaerobic gram‐positive rods were used in a systematic study of their biochemical and physiological reactions and morphological characteristics and were also subjected to gas chromatographic analyses in an effort to classify them as strains ofCorynebacterium acnes(C. acnes). The strains were isolated both from lesions in acne vulgaris and from normal skin. According to their biochemical and physiological characters, these 49 strains were divided into six subgroups (Subgroup A–F). They were also separated into two morphological types. The larger of these two types included gram‐positive, unevently staining pleomorphic rods (35 strains); the smaller type contained shorter coccal rods similar to Peptostreptococci (14 strains). The macroscopic appearance of the colonies of both types was the same. All strains of the smaller type showed the same biochemical and physiological characteristics which were of the saccharolytic type (Subgroup B) suggesting a close relationship between the microscopic appearance of the strains and their biochemical and physiological characteristics. Upon microscopical observation, the changing the pH of the media did not cause any transformation of the organism from one type to another. Between pH 6.0 and 6.5 all strains grew well but above pH 8.0 growth wai poor. The gas chromatographic analyses demonstrated that selected sample strains from each of the six subgroups showed the same characteristic chromatograph, suggesting that they could be of the same species, i.e.,C

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01037.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA case of Schönlein‐Henoch‐purpura is presented. The immunofluorescent study of skin lesions of the patient showed granular deposits of IgA and C3in the blood vessel walls perivascular deposits of plasminogen and diffuse localization of fibrin and fibrinogen in the upper dermis. Complement activation via the alternative pathway through IgA, C3and plasminogen deposits was sugge

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01038.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTEosinophilic lymphfolliculosis of the skin (Kimura's disease) in a 31‐year‐old male is reported. He had two subcutaneous tumors, 10 × 9 × 3 cm and 9 × 7 × 2 cm in size, in the right retroauricular and submaxillary areas respectively.Histopathologic examination of the tumors showed marked infiltration of eosinophils, mast cells and lymphocytes, and angiomatous proliferation of blood vessels from the dermis to the skeletal muscular tissue. In subcutaneous adipose tissue, there were numerous lymphfollicles with germinal centers in which IgE deposition with reticular appearance was observed by immunofluorescent technique. Study of the peripheral blood showed marked eosinophilia and an increase of serum IgE level.These findings suggest the possibility that Type 1 allergic reaction may be involved in the histogenesis of eosinophilic lymphfolliculosis of the skin, although there is no direct evidence for the existence of antigens which react to IgE antibody in the skin

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01039.x

年代:1977

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01040.x

年代:1977

数据来源: WILEY