摘要:

AbstractOrgan transplant recipients frequently develop warts which progress toward premalignant or malignant lesions after a rather long grafting period. The local immune responses of such lesions (warts, condyloma acuminata, actinic keratoses, Bowen, basal and squamous cell carcinomas) was studied in 32 frozen skin specimens taken from 15 male transplant recipients and compared to similar lesions from the normal population. We studied the expression of T cell subsets, Langerhans cell phenotype, HLA class 1 (β2‐microglobulin), HLA class 2 (DR antigen), and intercellular adhesion molecule 1 (ICAM 1). The presence of HPV infection was also considered, usingin situhybridization with biotinylated probes in order to examine the correlation with immunological markers. In the dermis, the lesions from grafted patients showed a moderate to intense inflammatory reaction of HLA‐DR‐positive cells. Most of these cells were CD4+ and CD8+ without any predominance of a single T cell subset. In the epidermis, most lesions were characterized by a reduced number of CD1‐positive cells; this was concomitant with a decrease or a loss of β2‐microglobulin expression by epithelial cells. HLA‐DR antigen was not expressed by keratinocytes or tumoral cells in any specimen; ICAM 1 antigen was observed in a few cases. The expression of these markers was similarly modified with or without the presence of HPV DNA. Conversely, most lesions from non‐immunocompromised patients, except warts, showed intense inflammatory reactions, with a predominance of CD4‐positive cells and large foci of ICAM 1‐positive cells. Expression of activation markers by keratinocytes occurred mainly in condylomas and squamous cell carcinomas. In the normal population, HPV infection was only detected in papilloma lesions. These data indicate, in lesions from grafted patients, a lack of effective immune response with partial inhibition of activation markers expressed by keratinocytes. It is conceivable that immunosuppressive treatment with solar exposure may also be responsible for the local immune deficiency and thus for the conversion of benign warts toward malignant lesions

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03183.x

年代:1992

数据来源: WILEY

摘要:

AbstractKeratinocyte intercellular adhesion molecule (ICAM)‐I expression is induced by interferon (IFN)‐γ. It has been previously reported that IFN‐β suppresses IFN‐γ‐induced ICAM‐I expression in A431 cells, a human squamous cell carcinoma cell line. In this study, the suppresion mechanisms were investigated at the post second messenger level. Both 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) and calcium ionophore (A23187) induce ICAM‐I expression in A431 cells. ICAM‐I expression induced by either was not suppressed with cotreatment with IFN‐β. Furthermore, IFN‐β did not inhibit the translocation of protein kinase C (PKC) by TPA. It appears that the pathways involved in ICAM‐I expression induced by activation of PKC or increased in intracel

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03184.x

年代:1992

数据来源: WILEY

摘要:

AbstractIntercellular adhesion molecule‐1 (ICAM‐1) is the ligand for lymphocyte function associated antigen‐1 (LFA‐1), mediating the adhesion of lymphocytes to vascular endothelium. Keratinocytes are known to express ICAM‐1 in some inflammatory dermatoses. Using an indirect immunofluorescence method, we examined the patterns of ICAM‐1 and LFA‐1 staining in bullous pemphigoid (BP) lesions and compared them to pemphigus vulgaris (PV) cases. ICAM‐1 was expressed on the cell surface and in the cytoplasm of epidermal keratinocytes at the sites of erythematous and bullous lesions of BP. LFA‐1 molecules were expressed on T cells at the basement membrane zone. In addition, HLA‐DR‐positive keratinocytes were observed in the basal layer. ICAM‐1 was not, however, expressed on epidermal keratinocytes in uninvolved skin from BP patients, PV or normal control skin. It is known that ICAM‐1 is expressed on keratinocytes at the site of lymphoid infiltration in cutaneous dermatoses and that LFA‐1‐positive T cells can bind to interferon gamma‐induced ICAM‐1‐positive keratinocytes. Our results suggest that cellular immunity involving ICAM‐1 and LFA‐1 may play a part in

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03185.x

年代:1992

数据来源: WILEY

摘要:

AbstractElectron microscopic and X‐ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X‐ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discus

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03186.x

年代:1992

数据来源: WILEY

摘要:

AbstractPercent ratios and absolute numbers of peripheral blood monocytes in patients with varicella and herpes zoster were determined and compared with those in patients with herpes simplex virus infection, measles and rubella. Monocytosis during the acute stage (p<0.01) was statistically significant in varicella and generalized and localized herpes zoster, compared with the levels in herpes simplex virus infection, measles and rubella. Absolute monocyte counts in varicella and HZ were significantly increased (p<0.02) beyond those of measles and rubella. The high % ratios of monocytes in varicella and herpes zoster during the acute stage decreased to normal ranges with cure.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03187.x

年代:1992

数据来源: WILEY

摘要:

AbstractA child's head‐sized tumor on the upper back developed in a 43‐year‐old man. In spite of an extensive operation for the tumor, he died of multiple metastasis 15 months after the operation. Histologically, tumor cells proliferated throughout the dermal and subcutaneous regions, and a boxed‐in appearance was noted with silver staining. Because electron microscopic observations strongly suggested a smooth muscle origin, we diagnosed this case as cutaneous and subcutaneous leiomyo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03188.x

年代:1992

数据来源: WILEY

摘要:

AbstractMuir‐Torre syndrome is characterized by multiple sebaceous tumors, various internal malignancies and an autosomal dominant inheritance. We herein report a typical case. The patient was a 69‐year‐old man with sebaceous adenomas, a keratoacanthoma, and actinic keratosis in addition to carcinomas of the prostate, colon, duodenum, and larynx. His family members also suffered from multiple ca

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03189.x

年代:1992

数据来源: WILEY

摘要:

AbstractThree cases of an unusual variant of porokeratosis (Mibelli) were described. Patients with disseminated superficial porokeratosis for some years suddenly developed intensively pruritic erythematous papules. Skin biopsies revealed that these papules contained cornoid lamellae on their tops. Pruritic papules subsided in several months, leaving slightly hyperkeratotic brown annular lesions which were shown to contain typical cornoid lamellae histopathologically. This type of porokeratosis has not been reported in the literature.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03190.x

年代:1992

数据来源: WILEY

摘要:

AbstractA 52‐year‐old Japanese woman with the chief complaint of marked swelling of her upper eyelids and a mass over the bulbar conjunctiva is reported. She previously noticed frequent purpura after minimal trauma, which was resolved shortly after taking some ascorbic acid. Laboratory data showed Ig‐G κ type M‐protein in the serum and κ type Bence‐Jones protein in the urine by Immunoelectrophoresis. Systemic examination showed mild hepatosplenomegaly, 1st degree of AV block, and a mild increase in plasma cells in the bone marrow biopsy. Histologically, the whole dermis of the eyelid skin and conjunctiva was replaced by a large quantity of amorphous, eosinophilic substances, which were diffusely positive with Direct Fast Scarlet 4BS. Immunohistochemical staining was positive for anti‐amyloid P component antibody. Typical amyloid fibrils were proved by electron microscopy. She was finally diagnosed as primary systemic amyloidosis with diffuse swollen eyelids and conjunctival mass, symptoms which in primary systemic amyloidosis

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03191.x

年代:1992

数据来源: WILEY

摘要:

AbstractWe present three unusual cases of molluscum contagiosum occurring in epidermal cysts. All of them are asymptomatic, elevated, oval nodules diagnosed clinically as epidermal inclusion cyst or prurigo nodularis. Histology showed true epidermal cysts containing molluscum bodies throughout the cyst wall and some type of laminated material within the cyst itself. The lesion, in all three cases developed in the pubic area of young adult men.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03192.x

年代:1992

数据来源: WILEY