ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00947.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTTo study the use of the Al‐test patch test units in Japan, Al‐test plaster was tested on 57 patients using 888 units and a skin reaction was seen under the aluminum foil section on 32 patients (179 unit, 20.15%). This is less than the irritation frequency of 34–65% reported when using Torii's test plaster and more than seen with our lint cloth and Blenderm patch test unit. In those cases having no reaction to the aluminum foil section, any positive reaction of the allergen was clear and easily recognizable. The probability of a false positive reaction due to skin irritation under the aluminum foil section when using Al‐test plaster in the summer in Japan, which has a comparatively higher humidity than Europe and the USA, was r

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00948.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTWhen lymph node cells from PPD‐sensitive guinea pigs were incubated with PPD for 20–24 hours, they produced a soluble mediator which inhibited the migration of normal guinea pig peritoneal exudate cells (GP‐PEC) out of capillary tubes. Also, human lymphocytes stimulated by antigen produced a soluble mediator which inhibited migration of normal GP‐PEC and peripheral leukocytes.Guinea pig migration inhibitory factor (MIF) was eluted in the 34,000–67,000 molecular weight (MW) region of cultured supernatants. Human MIF was harvested from the 25,000 MW region of cultured supernatants from human lymphocytes fractionated on Sephadex G‐100. Intradermal injection of the MIF into normal guinea pigs provoked reactions characterized by erythema and induration. The histologic response was found to be similar to that induced by antigen injection into sensitized animals. MIF from antigen stimulated lymphocytes may not have species specificity between guinea pig and human, although their molecular weights are different.No correlation was found between delayed skin reactivity induced by antigen in vivo and MIF production in vitro, and it is suggested that a substance inhibitory to MIF activity may be released in the lymphoc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00949.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTAcidic nuclear proteins and histones were extracted at several points in time from human lymphocytes cultured in media containing phytohemagglutinin, and their amounts were measured according to Folin‐Lowry's technique. The amount of acidic nuclear proteins continually increased, but the histone level neither increased nor decreased. It is suggested that acidic nuclear proteins might restore histone‐inhibited DNA‐dependent RNA synthesis in human lymphocytes activated by phytohemagglu

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00950.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTThe effects of occlusive treatment and stripping on the percutaneous absorption of a topical corticosteroid (17‐α‐desoxymethasone) were studied on human skin by means of a direct mounting method of autoradiography. A greater density of developed silver grains was found in the epithelium of occluded skin than in non‐occluded skin. The influence of occlusion on trans‐appendageal absorption was demonstrated by a greater density of grains in the cutaneous appendages of occluded skin as compared to non‐occluded skin. Further, a step‐wise increase in grain deposition was seen in specimens stripped repeatedly with adhesive tape. A partial removal of keratin by stripping was detected histologically, this suggests that the entire horny layer acts as a limiter of percutaneou

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00951.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTWeber‐Christian disease in a 25‐year‐old female was reported. She had recurrent erythematous nodules on the trunk and extremities, with fever, and microscopic examination of the nodules showed panniculitis due to lymphocytic and histiocytic infiltration and necrotizing angiitis.Studies of the peripheral blood showed marked anemia, leucopenia, and especially lymphocytopenia. There was a marked susceptibility to bacterial and viral infections. An increase of serum immunoglobulin level, a marked lymphocytopenia, a rather low percentage of lymphocytes transformed by PHA, and a reversion of the tuberculin reaction from positive to negative were found. She could not be sensitized by DNCB. These findings suggest a deficiency of cellular immunity and it is believed that these immunological abnormalities might be related to the etiology and pathogenesis of Weber‐Christian

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00952.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTA storiform neurofibroma on the back of a 23‐year‐old male is reported. The tumor grew slowly and continuously and with no sign of malignancy. The tumor was completely excised with no sign of recurrence in over one and one‐half years of follow‐up. The characteristic mat‐like structure and the presence of melanin in the cytoplasm of the tumor cells suggest that the tumor is of the melan

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00953.x

年代:1975

数据来源: WILEY