摘要:

ABSTRACTIn vitro transformation of peripheral lymphocytes by PHA was usually impaired in mycosis fungoides patients in the infiltrative plaque and tumor stages, while not being significantly impaired in the premycotic stage. A serum factor, reducing transformation by PHA, was demonstrated in 2 of 5 patients in the premycotic stage as well as in 2 and probably 3 of 4 patients in the infiltrative plaque or tumor stage. This serum factor affected both autologous (mycosis fungoides) and normal lymphocytes. The factor tended to be present in patients whose lymphocytes were impaired rather than in those whose lymphocytes were not significantly impaired. The degree of the reduction by mycosis fungoides serum seemed to correlate with the serum concentration of γ‐globulin rather than that of α2‐globulin. The possible nature and clinical significance of this factor are disc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01830.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTReported here are five cases of tick bite: in a 2‐year‐old boy, a 3‐year‐old girl, a 72‐year‐old woman, a 29‐year‐old woman, and a 51‐year‐old man. Four cases are thought to have occurred in a mountain area while one occurred in a city garden. None were accompanied with severe systemic symptoms or deuteropathies. The parasites were identified as the adult female tickIxodes ovatusNeumann (3 cases) andIxodes nipponensisKitaoka et Saito (2 cases), which are commonly d

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01831.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe microvasculature of the upper dermis in cases of systemic scleroderma was examined with an electron microscope. Microvessels in clinically uninvolved skin areas showed nearly normal structure. On the other hand, in moderately involved skin, enlargement of the vascular lumen, endothelial swelling, increase in the pinocytotic vesicle and microvilli and reduplication of the basal lamina were observed. Along with these, Ruthenium red‐positive granules, microfibrils and fine collagen fibrils were perivasculary increased. Markedly involved skin revealed a degenerative change in the endothelial cells with interendothelial gap; in the perivascular region the number of microfibrils and Ruthenium red‐positive granules decreased, and were replaced by increased collagen fibr

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01832.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe present paper reports on the penetration of salicylic acid, a substance with high permeability, through swine skin. Liquid scintillation counter and autoradiographic measurements were performed, on the excised swine skin to which ointment had been applied.The results indicated that the substance penetrated mainly through transfollicular route and was deposited transiently at various levels of each follicle, resulting in zig‐zag pattern on the liquid scintillation counter curve. The autoradiographic study also revealed a heavy transfollicular pattern of the substance though a slight transepidermal pattern was also noted.Whether the substance penetrates because of its lipid solubility or because of its affinity to the keratinous tissue is still open to questio

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01833.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe clinical and immunological studies of an unusual case of chronic mucocutaneous candidiasis (CMCC) are reported. An 18‐year‐old male with life‐long CMCC was superinfected by a dermatophyte showing exophytic clinical features in his childhood. In addition he has suffered from fatal cryptococcal meningitis since the age of 18. The combination of three fungi, i.e.,Candida albicans, Trichophyton mentagrophytesandCryptococcus neoformans, has not been found in an examination of the literature.The author's hypothesis, “immune deviation theory” in the pathogenesis of CMCC, is presented in detail.The possible role of hypovitaminosis A and disorder of iron metabolism in CMCC and treatment of CMCC are reviewe

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01834.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe prognosis of skin carcinoma and malignant melanoma was studied statistically. One hundred and one cases of basal cell epithelioma (BCE), 93 cases of squamous cell carcinoma (SCC), and 34 cases of malignant melanoma (MM) were studied. No cases of death due to basal cell epithelioma were found. The squamous cell carcinomas and malignant melanomas were classified according to the TNM system into three classes with different prognoses.The first class represents the initial stage, in which cure is expected if treatment is adequate. The second class is the intermediate stage, in which cure is uncertain and the prognosis depends upon the degree of extension. The third class is the late stage, in which distant metastasis is found and in which cure might not be anticipated. Furthermore, the prognosis of previously treated cases was poorer than that of untreated cases.Our findings indicate that early diagnosis and appropriate treatment in the initial stage results in the best prognosis and that the success or failure of the initial treatment has an appreciable influence on the prognosis of skin malignancy.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01835.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThirty‐three patients with pustulosis palmaris et plantaris were treated with large doses of vitamin B12(cyanocobalamin and/or coenzyme B12). Those patients receiving large doses for a long period of time showed a better response than those who received small doses for a shorter perio

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01836.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTPrevious studies have implicated a role for acidic nuclear proteins in the PHA stimulated activation of human lymphocytes. This study examines the mechanism of synthesis of these proteins. Cycloheximide inhibited their production, while Actinomycin D did not. It is suggested that synthesis proceeds by translation of dormant messenger RNA rather than of newly synthesized messenger RNA.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01837.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTFibroblast strains were obtained from 12 patients with xeroderma pigmentosum of various clinical types. Repair replication of UV‐damaged DNA in the fibroblasts was studied by3H‐thymidine labeling and radioautography. DNA repair replication was found decreased in all xeroderma pigmentosum fibroblasts compared with control cells obtained from normal donors. Repair activities in patients cells ranged from nearly 0% in three infant cases and two cases of De Sanctis‐Cacchione syndrome to approximately 100% in an adult moderate case. There was, however, no correlation between the level of repair replication and the severity of clinical symptoms. Since three cases which showed a lack of repair DNA replication were infants, it is assumed that these cases may develop De Sanctis‐Cacchione syndrome in the future. A genetic analysis of xeroderma pigmentosum cells, was performed with cell fusion methods using irradiated HVJ virus in order to determine the type of the complementation group. XP‐1, XP‐3, XP‐4, XP‐6 and XP‐9 may be classified into group D; XP‐2, XP‐7, XP‐8, XP‐11 and XP‐12 into group A

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01838.x

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThree patients with Scheie syndrome are reported on. They were suspected to be suffering from mucopolysaccharidosis because of clinical, histological and electron microscopic observations. The Scheie syndrome diagnosis was based on urinary GAG analysis. Chase experiments with cultured fibroblasts from one of the patients showed retarded degradation of85SO4‐labeled intracellular GAG. In addition, the pathogenesis of mucopolysaccharidoses in connection with cellular GAG metabolism is discusse

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1976.tb01839.x

年代:1976

数据来源: WILEY