摘要:

AbstractOver the 90 year history of dermatology in Japan, about 30 skin diseases have been first described by our colleagues. Although some of them have become well known internationally, many of them are less well known outside of Japan. In this article, we introduce those conditions first described in Japan which are lesser known but have international significance.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01712.x

年代:1994

数据来源: WILEY

摘要:

AbstractIt has been suggested that, in vitiligo, the structural abnormalities may not be restricted to melanocytes alone, but also to keratinocytes of involved and uninvolved skin. Focal gaps in the vitiligo epidermal basement membrane have been furthermore interpreted as evidence of extramelanocyte alterations. To understand the occurrence of the gaps we undertook a study to establish which cells are related to them. Immunofluorescence and immunoperoxidase techniques were used to visualize, in involved, uninvolved, and control skin, the basement membrane, melanocytes, and Merkel cells. Double staining was performed with fluorescein‐coupled anti‐collagen IV antibodies and rhodamin‐coupled antibodies against Nicein (GB3), a hemidesmosome component Propidium iodide staining was used to detect infiltrating lymphocytes.The basement membrane structure was always found to be intact and unaltered. Absence of staining in areas of uninvolved skin was related to the presence of Merkel cells, melanocytes, and infiltrating lymphocytes. Gaps in the epidermal basement membrane are thus due to lack of staining caused by the presence of immigrant

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01713.x

年代:1994

数据来源: WILEY

摘要:

AbstractA 72‐year‐old woman had a 7‐year history of a scaly red area on the right breast which had enlarged asymptomatically. A biopsy of the nipple was taken, and, following the finding of Paget's disease, a modified radical mastectomy was carried out. On histological examination of the entire breast specimen by serial sections, no evidence of an intraductal adenocarcinoma was found.Fractionation of Paget cells was performed from the epidermis. Stripped skin was treated with EDTA and trypsin, and epidermal cell suspensions were obtained. They were layered onto discontinuous Percoll gradients and centrifuged. Paget cells fell into three fractions with densities of 1.041, 1.058, and 1.078. Electronmicroscopically, the purity of fractionated cells obtained by this method ranged from 55 to 74% with viabilities of from 70 to 90%. Microscopic analysis of the DNA content in these cells was performed. The DNA histogram was close to the normal ploidy. This may explain why the mammary Paget's disease lesions in this case enlarged rather s

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01714.x

年代:1994

数据来源: WILEY

摘要:

AbstractWe studied the susceptibility of antimicrobial agents toPropionibacterium acnes (P. acnes)andStaphylococcus epidermidis (S. epidermidis)isolated from acne patients.We measured the minimum inhibitory concentrations (MICs) of the following five drugs: roxithromycin (RXM), erythromycin (EM), clindamycin (CLDM), minocycline (MINO) and ofloxacin (OFLX), which are frequently Used to treat acne and skin infections. We found many resistant strains ofS. epidermidisand some resistant strains ofP. acnes. There was a correlation between the resistance ofS. epidermidisand the former therapy for acne, but no distinct correlation between the resistance ofP. acnesand the former therapy for acne.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01715.x

年代:1994

数据来源: WILEY

摘要:

AbstractCutaneous lesions of T‐cell proliferative disorders are characterized by epidermotropic infiltration of the neoplastic cells and expression of intercellular adhesion molecule‐1 (ICAM‐1) and HLA‐DR by lesional keratinocytes. Using cloned HTLV‐1‐infected T‐cells obtained from patients with adult T‐cell leukemia (ATL), we have studied immunobiological activities of cytokines released from the T‐cell lines and their ability to adhere to cultured keratinocytes. Three out of the five CD‐4‐positive, HTLV‐1‐infected T‐cell clones secreted both IFN‐γ and IL‐4, similar to murine Th0 clones. The other two clones did not produce such cytokines. ICAM‐1 and HLA‐DR molecules were induced on cultured normal human keratinocytes and organ‐cultured skin specimens by co‐cultivation with IFN‐γ‐producing T‐cell clones or their culture supernatants. Induction of both molecules was markedly inhibited by pretreatment of the supernatants with excess amounts of anti‐IFN‐γ monoclonal antibody. The number of cells adherent to the normal cultured keratinocytes was greater in the IFN‐γ‐producing clones than in the non‐producing ones. These data suggest that some HTLV‐1‐infected clones produce cytokines, including IFN‐γ, which in turn induce ICAM‐1 on keratinocytes, thereby enhan

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01716.x

年代:1994

数据来源: WILEY

摘要:

AbstractChronic verruga nodules taken from a patient with Bartonellosis (verruga peruana) were studied. Histologically, specimens of all the verruga nodules had features consistent with granulomatous lesions with extensive infiltration of various types of cells along with the proliferation of capillaries. The sections were predominantly infiltrated with neutrophils and endothelial cells; histiocytes, plasma cells, lymphocytes and mast cells were also visible to some extent. The blood vessels were dilated, and many rounded and swollen endothelial cells were located peripherally; a huge number of neutrophils invaded the vessels. Electron microscopically, large number of organisms were seen in different stages of the life cycle in the stroma. Furthermore, organisms were regularly seen either in close contact or existing inside the cytoplasm of neutrophils, suggesting the phagocytic role of these cells. No organism was found inside any endothelial cells or histiocytes.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01717.x

年代:1994

数据来源: WILEY

摘要:

AbstractTwo bone marrow transplant recipients developed chronic graft‐versus‐host disease, presenting with a mild erythematous, pigmented eruption only on the face three and ten months after transplantation. Histologically, the lesions showed liquefaction degeneration of basal keratinocytes and incontinence of melanin in the upper dermis with a mild infiltrate of T‐lymphocytes. These findings suggest that such a facial eruption occasionally may represent an initial manifestation of chronic

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01718.x

年代:1994

数据来源: WILEY

摘要:

AbstractWe describe here a 35‐year‐old Japanese woman with mycosis fungoides (MF) who developed numerous, rapidly‐growing, seborrheic keratoses on the front of her neck and chest. To the best of our knowledge, this is the first reported case of MF with Leser‐Trélat sign fr

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01719.x

年代:1994

数据来源: WILEY

摘要:

AbstractWe report a case of a bullous variant of transient acantholytic dermatosis in a 59‐year‐old female. Each bullous lesion lasted several weeks and healed without scarring. The lesions were migratory and recurrent without a cleared period. Histopathologic examination revealed an intraepidermal vesicle low in the epidermis. The lesions cleared after 2 months of isotretinoin ther

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01720.x

年代:1994

数据来源: WILEY

摘要:

AbstractA boy with skin eruptions resembling varicella and specific for Langerhans cell histiocytosis (LCH) is reported. At his initial visit when he was four months old, vesiculopustular lesions were present over the entire body; these had first appeared on the third day post partus. Histopathological, immunohistochemical, and electron microscopical examination confirmed the Langerhans cell phenotype and Birbeck granules in the responsible cells. He also had hydronephrosis, recurrent fever, and cutaneous bacterial infections. His parents refused further medical treatment and he died of diarrhea with cachexia about two years later. LCH may present diagnostic difficulties by manifesting as a skin eruption which resembles varicella.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1994.tb01721.x

年代:1994

数据来源: WILEY