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1. |
INHERITED DISORDERS OF THE SKIN AND SKIN DISEASES DUE TO A HEREDITARY PREDISPOSITION* |
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The Journal of Dermatology,
Volume 1,
Issue 3,
1974,
Page 65-82
U.W. Schnyder,
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ISSN:0385-2407
DOI:10.1111/j.1346-8138.1974.tb01067.x
年代:1974
数据来源: WILEY
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2. |
EXPERIMENTAL CONTACT DERMATITIS IN MICE |
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The Journal of Dermatology,
Volume 1,
Issue 3,
1974,
Page 83-88
Yukio Kawamura,
Katsuya Sonobe,
Masayuki Shimizu,
Tsuguo Hamaguchi,
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摘要:
ABSTRACTDermatitis due to contact with DNCB was studied in mice. The reaction was shown by pathomorphological and autoradiographic studies to be an increase in epidermal mitotic activity.Sensitization of thymectomized mice, NZB mice, and passive transfer with peritoneal exudate cells demonstrated that this increase in epidermal mitotic activity is dependent upon cell‐mediated or delayed hypersensitivity.Although the induction of epidermal changes of eczematous contact dermatitis in mice has been considered difficult, by challenging acanthotic mouse epidermis we have been able to produce such changes as lymphocytic basal spongiosis.These results indicate that mice as well as guinea pigs are useful in experimental contact dermatiti
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1974.tb01068.x
年代:1974
数据来源: WILEY
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3. |
INDUCTION OF CONTACT SENSITIVITY BY EPIDERMAL MICROSOMES DINITROPHENYLATEDIN VITRO |
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The Journal of Dermatology,
Volume 1,
Issue 3,
1974,
Page 89-92
Kiyoshi Nishioka,
Kyoko Nishioka,
Toshiyuki Aoki,
Minoru Tashiro,
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摘要:
ABSTRACTEpidermal microsomes were dinitrophenylated in various concentrations to obtain the optimum ratio of hapten to microsome for induction of contact sensitivity. The epidermal microsomes with 494 μg of dinitrophenyl residue produced sensitization, whereas the sensitizing ability of those with less than 114 μg of dinitrophenyl residue was incomplete or lacking. The optimum amount of dinitrophenyl residue for sensitization of all animals tested was much higher than that in the epidermal microsomes extracted from DNCB treated animals.In order to exclude the possibility of free haptens trapped in the lipid component of the microsomal membranes being responsible for the results, Sanger's method of dinitrophenylation was used. (The epidermal microsomes prepared by Sanger's method also induced contact sensitivity.)Dinitrophenylated microsomes from guinea pig livers and spleens induced contact sensitivity in some animals, but they were less effective inducers than the dinitrophenylated epidermal microsome
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1974.tb01069.x
年代:1974
数据来源: WILEY
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4. |
COMPARATIVE STUDIES ON PHOTOTOXICITY OF CHEMICALS |
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The Journal of Dermatology,
Volume 1,
Issue 3,
1974,
Page 93-98
Fujio Kobayashi,
Yasushi Wada,
Nobuyuki Mizuno,
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摘要:
ABSTRACTAn attempt was made to establish in vitro and in vivo methods for screening phototoxic compounds. For an in vitro system, light dose‐survival curves ofEscherichia coliwere obtained. 8‐Methoxypsoralen (8‐MOP), bithionol (BT), 3,3′,4′,5‐tetrachlorosalicylanilide (TCSA), and 3,4′,5‐tribromosalicylanilide (TBS) showed photokilling activity againstE. coli, whereas hexachlorophene (HEX), trichlorocarbanilide (TCC), and irgasan CF3were photoinactive. Above a certain critical dose of ultraviolet radiation,E. colitreated with TCSA or TBS exhibited some recovery from phototoxic effects. For an in vivo system, median erythema dose, rather than minimal erythema dose, was determined for guinea pig skin. 8‐MOP, BT and TCSA proved to be phototoxic in both the in vivo and in vitro systems, but in vivo phototoxicity was not shown by HEX, TCC, irgasan CF3, and TBS, thus demonstrating a difference in TBS phototoxicity according t
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1974.tb01070.x
年代:1974
数据来源: WILEY
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5. |
STUDIES ON PHOTOSENSITIVITY CAUSED BY SULFA DRUGS |
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The Journal of Dermatology,
Volume 1,
Issue 3,
1974,
Page 99-103
Kazuo Aoki,
Masashi Shimotoge,
Tadao Saito,
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摘要:
ABSTRACTRepeated cutaneous applications of p‐hydroxylaminobenzene sulfonamide (PHABSA), which is a photo‐oxidation product of sulfanilamide (SNAm), sensitizes the guinea pig. By challenge with the substance, a marked cutaneous inflammatory reaction and an elevation of histamine level in the lesions are observed, although a single application of PHABSA to the non‐sensitized animals elicits neither a cutaneous reaction nor changes of histamine content.In addition, the cutaneous changes and elevation of histamine level induced by challenge in the sensitized animals are markedly suppressed by pretreatment with either histamine liberator or antihistaminic.Thus, it is presumed that PHABSA plays an important role in the photoallergic reaction caused by SNAm and that one of the mediators in this process is hist
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1974.tb01071.x
年代:1974
数据来源: WILEY
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