ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02620.x

年代:1982

数据来源: WILEY

摘要:

AbstractGuinea pigs immunized with antibiotics (sodium cephalothin, CET) developed a systemic, delayed‐onset rash or so called generalized rash (GR) when challenged intraperitoneally with large amounts of CET seven weeks later.Skin test reactivity and GR intensity were most prominent at 24 hours. Microscopically, skin test reactions and flare‐up lesions of old skin test sites during GR were characterized by the onset of dermal infiltration of lymphocytes, striking dilatation and compaction of superficial venules at 24 hours, and papillary dermal infiltration of basophils at 48 hours.In addition, the animals that developed GR exhibited eosinophilia at 24 hours, which was followed by basophilia at 48 hours.GR developed with large doses of CET has properties similar to the so called SCBH designated by H.F. Dvorak.This experimental model may serve as a useful model for drug reactions in man which may involve S

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02621.x

年代:1982

数据来源: WILEY

摘要:

AbstractThe process of formation of aqueous buffer‐insoluble proteins, which are tentatively regarded as keratins or their precursors, was investigated using epidermal cells cultured from guinea pig ear skin. It was found that cells in the early stages of the culture (proliferation stage) contained a small number of aqueous buffer‐insoluble proteins with molecular weights of 65K, 58K, 57K and 49K. After six days of culture (differentiation stage), cells rapidly formed these proteins, mainly consisting of 58K, 57K, and 49K proteins. In these cultured cells, 70K protein, which has been observed in the whole epidermis (in vivo), was not detected. Addition of the retinoid Ro10‐1670, an activated form of Ro10‐9359, into the culture medium accelerated the starting of the formation of these proteins, while inhibiting the formation of 65K and 45K polyp

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02622.x

年代:1982

数据来源: WILEY

摘要:

AbstractTwo cases of nevocytic nevi with nevus cells in the sebaceous gland were described. In the first case, the nevus seems to have been acquired but in the second case it is apparently congenital. As the sebaceous glands were presumably embryonic when the nevus cells settled into the corium, the immigration of nevus cells into the sebaceous glands might occur at the same time. The possibility of elimination of sebaceous cells by nevus cells is also pointed out.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02623.x

年代:1982

数据来源: WILEY

摘要:

AbstractA case of Woringer‐Kolopp disease was studied using electron microscopy. The patient was a 45‐year‐old Japanese woman with a plaque lesion of six years duration on the left upper thigh. The pathological features of the lesion included abnormal cells, mainly in the epidermis and compatible with those of Woringer‐Kolopp disease.Electron microscopic examination indicated that the abnormal cells within the epidermis and passing through the basal lamina had features indicating a histiocytic origin, including abundant and protruded cytoplasm and lysosomal dense

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02624.x

年代:1982

数据来源: WILEY

摘要:

AbstractAfter the acute onset of primary atypical pneumonia, a 4‐year‐old girl suddenly developed a widespread, sterile, pustular eruption with predilection toward the distal parts of the extremities. There was no involvement of the muco‐ocular area. Histological and electron microscopical examinations revealed intraepidermal pustule formation containing neutrophils and eosinophils, and perivascular infiltration of lymphocytes, histiocytes, neutrophils and eosinophils. These clinical findings are similar to those of Tan's “acute generalized pustular bacterid” and Teisch's “vesiculopustular eruption with mycoplasma infection”. Serological examinations, including complement fixation test, cold agglutination test, and passive hemagglutination test, confirmed aMycoplasma pneumoniaeinfection. It is concluded thatMycoplasma pneumoniaeinfection should be considered in patients with bacterid‐like rashes who do not have streptoco

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02625.x

年代:1982

数据来源: WILEY

摘要:

AbstractA patient with herpes gestationis associated with ectopic pregnancy is reported. She had circulating antibodies against basement membrane zone (BMZ) antigens of skin,in vivodeposition of IgG and complement components in a linear pattern along the BMZ of lesional skin, and positive herpes gestationis factor activity. Herpes gestationis associated with ectopic pregnancy has not been previously reported.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02626.x

年代:1982

数据来源: WILEY

摘要:

AbstractA 42‐year‐old woman who had been treated with corticosteroid for systemic lupus erythematosus had many yellow macules on her extremities and body. Light microscopic examination revealed a decrease or disappearance of collagen fibers and the formation of abnormal fibers. Ultrastructural study showed that these abnormal fibers were numerous cord‐like substances related to extracellular amorphous or filamentous materials and similar to the amorphous materials in the rough endoplasmic reticulum of fibroblasts.It was suggested that fibroblasts injured by corticosteroid produced an abnormal precursor of collagen fiber and that the synthesis of normal collagen fibers was inhibited in the yellow ma

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02627.x

年代:1982

数据来源: WILEY

摘要:

AbstractThe conjugation of some phenolic compounds with ten dansyl amino acids was examined and the results indicated the importance of conjugation with the lysine residue.The conjugation of phenolic compounds with monodansyl cadaverine and cadaverine was also studied. The results obtained by thesein vitrotests correlated well with those of animal sensitization tests and patch tests on patients with contact dermatitis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02628.x

年代:1982

数据来源: WILEY

摘要:

AbstractSkin irritability and sensitization potency of 14 phenolic compounds were studied on guinea pigs. When 10% preparations of each compound were used for induction, and 1% preparations were used for the challenge, the sensitization frequencies were 80% for isoeugenol and isosafro eugenol, 67% for isohomogenol, 40% for acetyl isoeugenol, 20% for eugenol, and 5% for dihydro eugenol. No animals were sensitized by methyl eugenol, acetyl eugenol, methyl isoeugenol or benzyl isoeugenol. The sensitization frequency was 80% for catechol, 89% for guaethol, 14% for p‐n‐propyl phenol, and 0% for phenol.The frequency of positive allergic reactions to patch tests on patients with cosmetic dermatitis was 2.6% for eugenol and 5.2% for isoeugenol. The frequency of cross reactions on patients sensitive to isoeugenol was also studied.The relationship between chemical structures and sensitization potencies as well as other factors influencing the results of patch tests on patients are discus

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02629.x

年代:1982

数据来源: WILEY