摘要:

AbstractSuppressor oncogene p53 is expressed more frequently in the nodular portion than the superficial spreading portion of the same melanoma. PCNA expression follows the same pattern but it is strongly expressed already in the superficial spreading portion. CD34 is found to label dermatofibrosarcoma protuberans. There is the mixture of negative strands but the immunostains are predominantly positive in the three cases studied. Neurogenic tumors are reactive but the intensity of staining is only moderate. Fibrous histiocytoma, dermatofibroma and other fibrohistiocytic tumors are non‐reactive. CD34 is expressed in the outer root sheath of hair follicle below the sebaceous gland level. A case of piloepidermal cyst is CD34 positive. CD34 is expressed in vascular endothelial cells; not only hemangiomas but also lymphangiosarcoma is CD34 positive. A case of indeterminate cell histiocytosis following scabies and superficial variant of clear cell sarcoma are discussed as examples of new entitie

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01333.x

年代:1993

数据来源: WILEY

摘要:

AbstractIn this study, we have utilized the human high molecular weight‐melanoma associated antigen (HMW‐MAA) as a target for active specific immunotherapy with mouse anti‐idiotypic (anti‐id) monoclonal antibodies (mAb) in patients with malignant melanoma. After having summarized the characteristics of HMW‐MAA which account for its selection as a target for immunotherapy, we describe the development and characterization of mouse anti‐id mAb MK2‐23 which bears the internal image of HMW‐MAA. Furthermore, we describe the results of the first clinical trial performed with mouse anti‐id mAb MK2‐23 in patients with

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01334.x

年代:1993

数据来源: WILEY

摘要:

AbstractThe relationship among minimal erythema dose (MED), minimal delayed tanning dose (MDTD), and skin color was examined in 16 healthy volunteers using three different spectra. The subjects were exposed to UVB, UVA+B, and UV+Visible light (UV+Visible) with a xenon arc solar simulator as a light source. The MEDs for UVB and UVA+B were less than the MDTDs, whereas the MED for UV+Visible was higher than the MDTD. There was no significant correlation between the MED and the MDTD for UVB or UVA+B. The MED for UV+Visible was significantly correlated to the MDTD (p<0.01). Skin color significantly correlated with MEDs for UVB and UVA+B (p<0.01), but not for UV+Visible. There was no significant correlation between skin color and the MDTD for any spectra. From these results, it is suggested that the relationship between erythemal and melanogenic responses is dependent on spectral bands of the light source and that skin color is a predictor of UV‐induced erythem

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01335.x

年代:1993

数据来源: WILEY

摘要:

AbstractTo investigate the hepatic abnormalities accompanying experimental protoporphyria due to griseofulvin (GF), liver function test values and porphyrin levels in mice were assayed at days 2, 4, 8, and 16 after starting the administration of 0.5% GF feed. Furthermore, in an attempt to elucidate the harmful effects of GF on liver functions, the above mentioned assay was also performed after the feed was discontinued in mice given 0.5% GF feed for 16 days.The hepatic protoporphyrin (PP) level had already risen by day 2, but the erythrocytic PP level was within normal limits at that time. Hepatic PP levels increased gradually, followed by an increase in erythrocytic PP levels. The variation in liver function test values roughly paralleled the porphyrin levels. Over the time span of the response to GF, the variations in the serum glutamate oxaloacetate transaminase (S‐GOT) levels, serum glutamate pyruvate transaminase (S‐GPT) levels, and leucine amino peptidase (LAP) levels resembled those in hepatic PP. On the other hand, the changes in alkaline phosphatase (ALP) levels paralleled those of the erythrocytic PP levels.Erythrocytic and fecal protoporphyrin levels decreased to the normal level one month after the discontinuation of GF administration, but the hepatic protoporphyrin level still was 53.6 times higher than the normal level two months after switching to normal feed. The values of liver function tests had returned to within the normal range after one month.By the fourth day after the administration of GF, a brown pigmented material could be observed around the hepatocytes and the Glisson sheath; the amount of this material increased day by day. Its amount gradually decreased after cessation of GF.These results suggested that the hepatic abnormalities were not induced by the deposition of PP in the liver, but by the direct toxicity of GF. This means that GF‐induced protoporphyria mice are not suitable for investigating porphyric damage to the liver because of the strong hepatic intoxication by GF. However, they may be useful for studies of the removal of deposits of porphyrin granules from the

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01336.x

年代:1993

数据来源: WILEY

摘要:

AbstractA case of dermal duct tumor on the back of a 61‐year‐old male, representing a cystic lesion, is reported. Such cystic dermal duct tumors seem to be considered poroid hidradenomas according to the recently suggested classification of poromas. Poroid hidradenoma is rarely mentioned in the literature, and no description of its clinical features has yet been published. Carcinoembryonic antigen (CEA) immunostaining was positive in the tumor cells adjacent to the cystic space. We suppose that these CEA‐positive cells were associated with cyst formation in our

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01337.x

年代:1993

数据来源: WILEY

摘要:

AbstractCalcinosis cutis is a frequent complication of juvenile dermatomyositis; however, its treatment remains unsatisfactory. We report a case of calcinosis cutis in juvenile dermatomyositis which was successfully treated with oral aluminum hydroxide. Almost complete clearing of calcinosis was observed after 8 months of therapy. There were no adverse effects from therapy. Aluminum hydroxide is worth trying in treating calcinosis cutis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01338.x

年代:1993

数据来源: WILEY

摘要:

AbstractWe report a 22‐year‐old man with acquired dermal melanocytosis on the hand which developed without any history of previous inflammation. He had no history of contact with or oral administration of any drugs or metals which might have caused pigmentation. Histopathologically, spindle‐shaped dermal melanocytes were observed running parallel to the collagen bundles and scattered in all portions of the dermis. The dopa reaction of these cells was positive. Ultrastructurally, dermal melanocytes containing numerous melanosomes (stages II to IV) which were surrounded by the extracellular sheath were observed. Differential diagnosis of other dermal melanocytosis was disc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01339.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 46‐year‐old female had suffered from systemic lupus erythematosus (SLE) for 8 years. Headache, vomiting and stiff neck appeared in the active phase of SLE. Findings in the cerebrospinal fluid were consistent with those of lupus meningitis. No pathogenic microbes were detected by microbiological or immunological examinations. She was diagnosed as having lupus meningitis.The method discussed herein which elucidates the cause of fever in SLE using white blood cell count (WBC) and alpha‐2 globulin appeared to be useful for examining this case of meningitis.Lupus meningitis seems to preferentially occur in SLE patients with positive anti‐ribonucleoprotein (RNP) antibody.Pulse therapy with methylprednisolone appeared to work well in this lupus meningitis patient who had had a long course of corticosteroid

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01340.x

年代:1993

数据来源: WILEY

摘要:

AbstractWe report a 30‐year‐old Japanese male with acrogeria. He was in good health except for the prominent skin atrophy over the hands and feet. In the microscopic view of an atrophic skin biopsy specimen, elastic fibers were clumped and fragmented, especially in the upper dermis. Reviewing fourteen previously reported Japanese cases of acrogeria, the decrease and degeneration of elastic fibers were the prominent characteristic, as was the atrophy of subcutaneous

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01341.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 46‐year‐old Japanese man with isolated lichen planus of the nails is reported. The affected nails were all of the fingernails and the third and fourth toenails of both feet. Histologically, the ventral part of the proximal nail folds showed mild band‐like cell infiltration below the epidermis, and the nail beds (ventral matrix) showed hypergranulosis and epidermal‐dermal interphase activity with liquefaction degeneration of basal cells and a band‐like cell infiltration consisting of lymphoid cells and histiocytes. Systemic use of etretinate in combination with application of steroid lotion was evaluated as very effective. Although the use of retinoids for lichen planus of the nails remains only a suggested method of treatment, a positive trial should be attempted, since this disorder sometimes results in severe na

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01342.x

年代:1993

数据来源: WILEY