ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03818.x

年代:1992

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03819.x

年代:1992

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03807.x

年代:1992

数据来源: WILEY

摘要:

AbstractPreirradiation of contact sensitizing sites to low‐dose ultraviolet B (UVB) renders animals unresponsive to challenge reaction. This unresponsiveness is known as local, low‐dose UVB‐induced immunosuppression. Although researchers in this area have developed theories, the exact mechanisms of UVB‐induced immunosuppression are still a matter of controversy. This article reviewed various scientific data on UVB‐induced immunosuppression, categorizing them into individual sequential steps in the whol

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03808.x

年代:1992

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03809.x

年代:1992

数据来源: WILEY

摘要:

AbstractThe immunohistochemical expression of Neuron‐Specific Enolase (NSE) and of S100 protein was studied in 10 cases of cutaneous and 19 cases of extracutaneous Langerhans cell histiocytoses (LCH), including acute/proliferative forms (cutaneous Letterer‐Siwe disease) and chronic/granulomatous forms (eosinophilic granuloma, Hand‐Schüller‐Christian disease). Of the LCH cases, 18 (62%) exhibited detectable NSE‐immunoreactivity as compared to 82.8% for S100. NSE expression was found more frequently and intensely within acute (as compared to chronic) forms of LCH. This result lends further support to the cellular unicity of LCH, but also suggests some degree of heterogeneity among LCH cells. It can be speculated that NSE‐expression is correlated with the proliferation/activation state of (abnormal) Lang

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03810.x

年代:1992

数据来源: WILEY

摘要:

AbstractA gelatin particle agglutination assay for the detection of anti PGL‐I antibodies in 40 clinically diagnosed and variously classified groups of leprosy cases revealed elevated PGL‐I antibody titers in 85% of cases. In contrast, the slit‐skin smear examination was positive in only 30% of cases. It was further observed that, out of 28 cases with Bacteriological Index (B.I.) zero, 22 cases (78.5%) had significant levels of PGL‐I antibodies. There was no case in which the slit skin smear was positive and the PGL‐I antibody titer was not significant. The elevated titers of PGL‐I antibody better correlated (84%) with histopathological findings than did B.I. Thus it was concluded that estimation of PGL‐I antibody titer is a better supplement to clinical diagnosis than B.I.Significant levels of PGL‐I antibody were seen in 85% of cases who had no earlier chemotherapy or were treated for less than 2 months. Similar findings were observed in 12 patients who were on MDT for more than 5 months but for less than 2 years. In order to determine the significance of anti PGL‐I antibodies in monitoring the response of patients to chemotherapy, a longer follow up with a greater number of cases shoul

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03811.x

年代:1992

数据来源: WILEY

摘要:

AbstractAs part of a study of the mechanism of metronidazol's efficacy in the treatment of acne and rosacea, its effects on the endocrine milieu and sebum excretion rate were assessed. Thirteen healthy males received oral metronidazole treatment (500 mg/day) for 4 weeks.Serum sex hormone levels were determined in all 13 subjects and the sebum excretion rate was determined in seven of them, before and after treatment. We measured serum levels of estrone (E1), estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA‐S), and sex hormone‐binding globulin (SHBG). There were no significant changes in E1, T, FT, DHT, or SHBG levels, but E2and DHEA‐S levels decreased significantly after treatment. In all seven subjects in whom the sebum excretion rates were determined, the amount of facial skin surface lipids decreased significantly after treatment.These results suggest that metronidazole exerts its clinical effects through suppressing the sebum excretion by a mechanism other than anti‐androgenic

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03812.x

年代:1992

数据来源: WILEY

摘要:

AbstractPompholyx (Dyshidrosis) is a disease of unknown etiology presenting as symmetrical, vesicular hand and foot dermatitis. To clarify the pathogenetic role of sweat and metal allergy, twenty five patients with pompholyx were examined with respect to their perspiration volume using equipment that continuously recorded the local perspiration volume. Patients were also examined for metal allergy by patch testing and oral challenge tests. The perspiration volumes were measured using recently developed equipment for continuous recording of local perspiration volume (Kenz‐Perspiro oss‐100®). The perspiration volume of pompholyx patients was found to be 2.5 times higher than that of age‐matched normal controls. Twenty percent of the patients showed sensitivity to chromate, 16% to cobalt, and 28% to nickel on patch testing. Six patients with positive results were challenged orally in a controlled trial with 2.5 mg nickel, 1 mg cobalt, or 2.5 mg chromium. Four of them (67%) showed vesicular reactions on their hands with challenge testing. These results indicated a sensitivity to metal compounds which, in combination with local hyperhidrosis, may contribute to the development of vesicular lesions in pom

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03813.x

年代:1992

数据来源: WILEY

摘要:

AbstractA case of systemic sclerosis (SS) which developed keloidal lesions (nodular scleroderma) on the chest during D‐penicillamine (DPC) therapy is reported. The 36‐year‐old woman showed rapidly progressing skin sclerosis with lung and esophageal involvement, and DPC was started at the age of 38. Skin sclerosis as a whole had improved to some extent, when keloidal nodules developed on the upper chest at the age of 44. Since there were no other findings suggestive of adverse reactions caused by DPC, we speculate that activation of the fibroblasts in these lesions occurred despite the suppressive effect o

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03814.x

年代:1992

数据来源: WILEY