摘要:

AbstractWe examined the functional roles of HLA‐DR+keratinocytes which were inducedin vivofrom tuberculin reactive skin. At 4 days after intradermal PPD injection, about 80% of keratinocytes obtained from the tuberculin reactive area expressed DR antigens. In 14 of 18 individuals examined, PPD‐pulsed DR+keratinocyte fraction induced autologous T‐cell proliferation. The proliferative response was PPD‐dependent, antigen specific; it depended upon DR expression by the keratinocyte fraction, because it did not occur in the presence of the PPD‐nonpulsed DR+keratinocyte fraction and was completely blocked by mouse monoclonal antibody to HLA‐DR. However, the antigen‐presenting capacity of the DR+keratinocyte fraction appeared to be less than that of monocytes or the DR+epidermal cell fraction. The DR+keratinocyte fraction was also able to stimulate allogeneic T‐cell DNA synthesis, but the DR−keratinocyte fraction could not. The possible influences of contaminant Langerhans cells and mononuclear cells in the DR+keratinocyte fraction were considered to be unlikely. These results suggest that DR+keratinocytes, which are inducedin vivo, can both present the antigen to autologous T cells and stimulate a

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03066.x

年代:1991

数据来源: WILEY

摘要:

AbstractEmploying an avidin‐biotin complex immunoperoxidase technique, it was found that there was OKM5 but no OKM1 antigen expression on the keratinocytes of the upper epidermis from all the studied specimens of seborrheic keratosis, verrucous nevus, Bowen's disease, BCC, SCC, MM, lichen planus, psoriasis vulgaris, condyloma acuminatum, and sporotrichosis as well as in two of eight cases of nevus pigmentosus. Our findings indicate that OKM5 antigen expression on epidermal keratinocytes is usually associated with dermal infiltration. It is assumed that human keratinocytes in cutaneous lesions, like the OKM1−OKM5+monocyte/macrophage lineages, might play certain roles in immune responses and possibly function as antigen‐presenting

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03067.x

年代:1991

数据来源: WILEY

摘要:

AbstractForty‐seven adolescent and adult patients suffering from long‐standing atopic dermatitis (AD) too severe to respond to conventional therapies were treated with topical psoralen photochemotherapy (PUVA) and relatively low doses of ultraviolet (UV) irradiation. For practicality and convenience, two different therapeutic regimens were implemented; short‐term hospitalization with almost daily irradiation (inpatient group, n=23) and weekly irradiation combined with topical corticosteroids which had failed to manage symptoms before initiating the treatment (outpatient group, n=25). Excellent therapeutic effects were achieved in 72% of the inpatients after 5–38 (mean 18.2) times of irradiation (mean cummulative dose; 44.7 J/cm2). In addition, 56% of outpatients responded excellently to the treatment after 6–22 (mean 13.0) times (mean cummulative dose; 25.8 J/cm2). In fact, 16 of the inpatients and 10 of the outpatients achieved almost complete remission. The duration of remission in these patients was 1–25 months (mean 6.3 months) in the inpatients and 1–6 months (mean 3.0 months) in the outpatients.Peripheral blood eosinophils significantly decreased after the treatments. A follow‐up study showed a delayed decrease in serum IgE levels. In contrast, the specific IgE to house dust antigens and the water holding capacity of stratum corneum did not vary

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03068.x

年代:1991

数据来源: WILEY

摘要:

AbstractA 28‐year‐old woman was treated for seminal fluid allergy with immunotherapy using a one‐day ‘rush’ procedure. Apart from minor anaphylactic symptoms, no serious side effects were noted during or after hyposensitization or boostering. Five weeks after the start of the hyposensitization, she was free of symptoms after unprotect

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03069.x

年代:1991

数据来源: WILEY

摘要:

AbstractThirteen cases among 16,260 patients seen at our department during the nine years from 1981 were diagnosed as pseudoxanthoma elasticum (PXE). The sex and age distributions were similar to those so far reported in the literature. There were two cases of the autosomal dominant type. One patient had skin lesions typical of PXE in association with Ehlers‐Danlos syndrome. In two of three patients with cutis laxa‐like lesions, eruptions of elastosis perforans serpiginosa were present. In three cases, we failed to detect deposition of calcium in typical skin lesions in either an early or a late stage by histochemical staining, in spite of the presence of slightly degenerated elastic fib

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03070.x

年代:1991

数据来源: WILEY

摘要:

AbstractA case of cutaneous metastasis of renal cell carcinoma in a 67‐year‐old man is described. Right side nephrectomy had been performed three years earlier, and a renal cell carcinoma was diagnosed. Following a bruise, the patient noticed an erythematous nodule on the scalp. Histological examination of this skin lesion showed atypical tumor cells consisting predominantly of clear cells with a honeycomb‐like or adenoid structure. Electron microscopic examination revealed that the tumor cells were divided into three groups: clear cells with abundant glycogen, dark cells with abundant mitochondria, and intermediate cells containing both glycogen and mitochondria in varying proportions. Some of the tumor cells with an adenoid pattern had a brush border‐like structure in the lumen. These results support the diagnosis of metastatic renal cell carcinoma. An electron microscopic approach may aid in diagnosis of cutaneous metastasis from renal cell ca

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03071.x

年代:1991

数据来源: WILEY

摘要:

AbstractPurpura fulminans is a rare disease characterized by purpura ecchymosis, hypotension, and fever associated with disseminated intravascular coagulation. It often begins as a benign infectious process and subsequently progresses to a severe, catastrophic outcome. It is recognized to originate from congenital or acquired protein C deficiency. We present an unusual case of an adult with Xanthomonas maltophilia sepsis that subsequently developed into purpura fulminans with involvement of the four extremities. We discuss the importance of the protein C system in coagulation homeostasis and its relationship to purpura fulminans.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03072.x

年代:1991

数据来源: WILEY

摘要:

AbstractIdentical twin sisters developed generalized erythema and bullae on skin and mucous membranes at 18 and 19 years of age. Atrophic scars and milia were formed later. Indirect immunofluorescence (IF) study of the separated skin by incubation in 1.0M NaCl showed anti‐basement membrane zone (BMZ) antibodies bound to the dermal side. The HLA‐DR typing demonstrated DR2/DW11. Pulse therapy resulted in marked clinical improvement. This is the first report of epidermolysis bullosa acquisita (EBA) in identical twins and suggests the possibility that the disease may have a genetic compon

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03073.x

年代:1991

数据来源: WILEY

摘要:

AbstractA 8‐month‐old boy showed several yellow to brownish yellow, papular and/or nodular eruptions predominately on the face. Initial clinical and histologic findings indicated possible juvenile xanthogranuloma or papular xanthoma. Since his second year, the papulonodular lesions have gradually merged into large confluent plaques, particularly on the face, nape, and axillae. Consequently, it was considered that his condition had terminated in diffuse plane xanthoma. Serum lipid panels showed normolipemia. Finally, a diagnosis of papuloeruptive xanthomatosis with normal lipid metabolism and no associated systemic disorders was made. The patient's papulonodular lesions have continued to involute spontaneously since the age of th

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03074.x

年代:1991

数据来源: WILEY

摘要:

AbstractA 56‐year‐old man suffered from cutaneous squamous cell carcinoma (cutaneous SCC) which occurred on a cutaneous lesion of sporadic porphyria cutanea tarda (sporadic PCT).His liver function decreased from the time he was infected withSchistosoma japonicumat the age of 10. He drank a little alcohol.Erythematous maculae with blisters or erosions occurred on sun‐exposed areas of his skin when he was 52. His urine continued to be red. After detailed examinations including liver biopsy, he was diagnosed as having sporadic PCT due to liver disorder after infection withSchistosoma japonicum.At the age of 56, a small red papule arose on his right earlobe at the site of a sporadic PCT lesion. The papule rapidly enlarged with ulceration; this completely destroyed his right earlobe, which was covered with odoriferous yellow‐white necrotic tissue. The tumor then extended to his right preauricular area with ulceration. A skin biopsy confirmed well‐differentiated cutaneous SCC.The association of cutaneous SCC with sporadic PCT has not been previously reported; we think that the association is significant Such an occurrence may have been induced by either direct or indirect effects of ultraviolet light or a scar formed by the spo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1991.tb03075.x

年代:1991

数据来源: WILEY