摘要:

AbstractSpotted fever group rickettsioses comprise Rocky Mountain spotted fever (Rickettsia rickettsii), boutonneuse fever (R. conorii), North Asian tick typhus (R. sibirica), Queensland tick typhus (R. australis), rickettsialpox (R. akari), and Oriental spotted fever (R. japonica). Ticks or mites serve as the vector and reservoir hosts of the rickettsiae. These obligate intracellular bacteria invade vascular endothelial cells, which are damaged directly, causing increased vascular permeability. The rash usually appears in Rocky Mountain spotted fever on the third day of illness and later evolves to become petechial maculopapules in 50% of cases with involvement of the palms and soles in a similar proportion of patients. Eschar occurs in some SFG rickettsioses at the site of tick bite, but rarely in Rocky Mountain spotted fever. Diagnosis often proves difficult, and laboratory assays for antibodies to SFG rickettsiae are generally useful only in convalescence. Rickettsiae are demonstrable by diagnostic immunohistology in biopsies of rash or eschar. Empiric treatment with doxycycline, tetracycline, or chloramphenicol should be given early in the course on the basis of clinical suspicion of the diagnosis of a SFG rickettsiosis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01244.x

年代:1989

数据来源: WILEY

摘要:

AbstractBased on the activity of transglutaminase, the change of antigenicityin situof hematoxylin stainable protein (HSP) purified from 3‐day‐old rat epidermis and located on the cell membrane region of the stratum corneum was investigated by indirect immunofluorescent technique using a polyclonal antibody against hematoxylin stainable protein. Three different techniques were employed: (i) the skin section was incubated with a commercial guinea pig liver transglutaminase (GLT), (ii) the skin section was incubated with an epidermal extract of Tris‐HCl (EX), and (iii) the skin section was incubated with an epidermal extract of 1% Triton X‐100 (EXT). The sections incubated in Tris‐HCl or Triton X‐100 were used as controls. Each incubation was done both in the presence and absence of Ca2+ions. After these incubations, an indirect immunofluorescent technique using a polyclonal antibody was performed. In the presence of Ca2+ions, the specific fluorescence of the cell membrane region of the entire stratum corneum cells disappeared after the preincubation with GLT. That of the lower one third of the stratum corneum disappeared after the incubation with EXT. In contrast, in the absence of Ca2+ions, no preincubation with GLT, EX, or EXT showed any disappearance of the fluorescence anywhere in the stratum corneum. There was also no disappearance of the fluorescence in the control sections. These findings suggest that the antigenicity of HSPin situcould be lost by the activity of trans

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01245.x

年代:1989

数据来源: WILEY

摘要:

AbstractEpidermal Growth Factor (EGF) plays an important role in cell proliferation. In psoriasis, increased histochemical expression of EGF receptor has been reported in the epidermis. In order to elucidate the mechanism of this increase, we studied the EGF receptor gene organization in psoriasis. DNAs were extracted from white blood cells of 5 patients with psoriasis and 5 normal controls and also from epidermis of 2 psoriatic patients and 1 normal control, and analyzed by Southern blot technique. There were no differences in the structural organization of EGF receptor gene in either white blood cells or epidermis between psoriatic patients and normal controls. These results suggest that the histochemical increase of EGF receptor in the epidermis of psoriatic patients is not due to a structural change in this gene.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01246.x

年代:1989

数据来源: WILEY

摘要:

AbstractDistribution of Japanese skin types (JSTs), sun‐exposure habits, and sunscreen use were surveyed in 379 new outpatients. The largest number of subjects belonged to JST class J‐II (65%), J‐I was second (24%), and J‐III was third (11%). Eighty‐eight percent of those studied had occasional or habitual sun exposure during the summer, and many were exposed for more than three hours per exposure day (80% of those with occasional exposure; 62% of those with habitual exposure). More younger persons had occasional sun exposure than older persons. More males had habitual sun exposure than females. Sunscreens were used by 41% of the subjects, but 77% of these used them without accurate understanding of the definition of the sun protection factor. More J‐I subjects used sunscreens than J‐II and J‐III subjects. More females than

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01247.x

年代:1989

数据来源: WILEY

摘要:

AbstractWe have made electron microscopic studies on the elastotic material of solar elastosis which developed in cutis rhomboidalis nuchae taken from 10 males, 50–83 years of age. It was revealed that this material of the cutis rhomboidalis nuchae contained a colloid‐like substance consisting of both a fine granular and an amorphous component. The colloid‐like substance closely resembled that which is seen in the adult‐type colloid milium, and could not be distinguished from it under light microscopy.In view of the morphological similarity at the ultrastructural level between the elastotic material and the colloid‐like substance, it was proposed that normal elastic fibers can change into elastotic material and then further degenerate into the colloid‐like substance, eventually becoming the typical colloid substance seen in col

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01248.x

年代:1989

数据来源: WILEY

摘要:

AbstractThe newly‐generated lipid mediators include products of arachidonate metabolism, prostaglandins and leukotrienes. In this study, serum lipids and fatty acids, including arachidonic acid (C20:4) were examined in 12 normal subjects (6 males and 6 females) and 23 subjects with chronic urticaria (6 males and 17 females), including 17 who made an excellent or good recovery (4 males and 13 females). The results indicated a relationship between chronic urticaria and serum lipids and fatty acids. Theω6 (n‐6) andω3 (n‐3) series of polyunsaturated fatty acids and lipid peroxidation were suggested that may be one of the mediators in chronic urticaria. Pantethine, glutathione and ascorbic acid were effective in controlling chronic ur

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01249.x

年代:1989

数据来源: WILEY

摘要:

AbstractProlyl hydroxylase (PH) and procollagen III peptide (PIIIP) levels in 43 serum samples from various collagen diseases including 19 progressive systemic sclerosis (PSS) cases were simultaneously assayed and compared to those of 22 age‐matched psoriasis patients and 20 healthy controls in order to examine whether they can serve as useful parameters of fibrotic changes, especially in the skin. Serum PH levels were determined with enzyme immunoassay and serum PIIIP levels with radioimmunoassay. The average values of PH were 109% (n=3, p<0.001; generalized morphea, GM), 104% (n=1; overlap syndrome, OS), 57% (n=6; mixed connective tissue disease, MCTD), 48% (p<0.05; PSS), 33% (n=5; dermatomyositis, DM), 28% (psoriasis), and 9% (n=9; systemic lupus erythematosus, SLE), higher than the control levels, while those of PIIIP were 82% (OS), 57% (MCTD), 42% (p<0.01; PSS), 11% (GM), and 5% (DM) higher and 22% (psoriasis) and 28% (SLE), lower than the controls. These results indicate that both values were higher in the diseases with skin fibrosis and lower in those without it, suggesting that both assays generally reflect the state of actual progression of fibrosis at the point of determination. These two values had considerable correlation; however, GM, psoriasis and SLE patients had relatively higher values of PH than of PIIIP. This result suggests that the PH assay may also reflect the state of connective tissue activation; therefore the PIIIP assay may be more specific for pathological fibrotic process. Thus it seems that these two assays can serve as parameters of the activity of fibrotic skin diseases, especially when assayed simultaneously and regularl

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01250.x

年代:1989

数据来源: WILEY

摘要:

AbstractTo evaluate the mechanism of mosquito bite reaction in man, the reaction toAedes albopictuswas observed in 162 subjects ranging in age between 1 to 68 years old. Bite reactions were found to consist of both an immediate and a delayed reaction. The eruption and time course of the immediate reaction were consistent with type I hypersensitivity. The eruption and time course of the delayed reaction were consistent with cutaneous basophil hypersensitivity. Positive rates of immediate reaction increased from early childhood to adolescence and decreased with age from adulthood. The appearance and intensity of the delayed reaction decreased with age. Mosquito bite reactions in human beings exposed continuously and regularly are known to change from stage 1 to stage 5 (stage 1; no reaction, 2; delayed reaction only, 3; immediate and delayed reaction, 4; immediate reaction only, 5; no reaction). Analysis of the relationship between age and bite reaction in this study indicated that the principle held true even when the exposures were irregular or at random.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01251.x

年代:1989

数据来源: WILEY

摘要:

AbstractA close correlation between purpuric reaction and drugs was observed in seven cases of chronic pigmented purpura. The patients developed purpuric lesions after taking certain drugs for more than 3 years, were thiamine propyldisulfide in 2 cases, and chlordiazepoxide in 1 case. The purpuric lesions stopped recurring after removal of the drugs in the rest of the cases. It is suggested that drugs are among the etiological factors in chronic pigmented purpura.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01252.x

年代:1989

数据来源: WILEY

摘要:

AbstractFifteen percent of 3684 patients with eczema attending a contact clinic presented with head and/or neck eczema. There were epidemiological differences among eczema rashes occurring on different parts of the head and neck. Of the 538 patients with head and/or neck eczema, 345 (64%) occurred solely on the face, 52 (10%) on the eyelids, 49 (9%) on the lips, 20 (4%) on the ears, 22 (4%) on the scalp, and 21 (4%) on the neck. Twenty‐nine (5%) had eczema on more than one area of the head/neck. The mean age was lowest in patients with lip eczema (27.5 years) and highest in patients with eyelid eczema (37 years) (p=0.0056). The proportion of females with eczema was higher than males in all groups except the scalp eczema group. Contact dermatitis was more prevalent in the ear eczema (80%) and neck eczema (76%) groups, while endogenous/unclassifiable eczema was more prevalent in the lip eczema (72%) and scalp eczema (73%) groups (p<0.0001). Allergic contact dermatitis was more common than irritant contact dermatiti

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1989.tb01253.x

年代:1989

数据来源: WILEY