摘要:

ABSTRACTExplant cultures of domestic pig skin were used to study the effects of db‐cAMP and related compounds on epidermal outgrowth and mitotic index in the outgrowing epidermis. Db‐cAMP and related compounds which elevated intracellular concentrations of cyclic AMP had inhibitory effects on epidermal outgrowth and mitotic index. Treatment with db‐cAMP in an early “migratory” phase revealed that db‐cAMP inhibited the migratory activities of epidermis

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02572.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTMolecular heterogeneity of adenosine deaminase in pig epidermis is reported. Gel filtration of pig skin extracts with Sephadex G‐150 revealed the existence of two forms of adenosine deaminase. Molecular weights of the enzymes were around 30,000–40,000 and 300,000–350,000 respectively. Several catalytic properties of these two adenosine deaminases were quite similar: Km value, substrate specificity, pH activity profile, and the effect of coformycin, a strong inhibitor of adenosine deam

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02573.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTBy using scanning electron microscopy (SEM), three dimensional structures of the matrixes and fibrous components in human dermal skin, scleromyxedema, systemic lupus erythematodes (SLE), progresive systemic sclerosis (PSS) and amyloidosis cutis were observed. SEM pictures were compared with those from conventional transmission electron microscopy and histochemistry. In human dermal skin and scleromyxedema, the matrixes were not fixed in glutaraldehyde and osmic acid. FAC fixation was employed in these specimens. After fixing specimens, streptomyces hyaluronidase digestion was made and examined by the SEM. In human dermis and scleromyxedema, hyarulonic acid occurred between collagen and elastic fibers.In systemic lupus erythematodes and progresive systemic sclerosis, specimens were fixed in glutaraldehyde and osmic acid, and examined in the same way. In SLE, collagen fibers were dissociated and the normal wavy pattern was lost. In PSS, abnormally increased branching fibers were observed. In amyloidosis cutis, amyloid fibrils were not observed by conventional SEM. Specimens were dehydrated in a critical point dryer and examined by the field emission scanning microscope. Amyloid fibrils were interwoven in a felt‐like fashio

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02574.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTIn order to evaluate the effect of ethyl ether application to recurrent herpes simplex, recurrence intervals were checked on patients who had been followed up for over 3 years. Typical recurrent herpes simplex cases were selected and topical ether applications were made with ether soaked cotton swabs for 10 minutes several times a day for two days. Results revealed that topical ether application remarkably prolonged the recurrence interval. In this regard, ether application was effective in the treatment of recurrent herpes simplex.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02575.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTWhile it is generally accepted that psoriatic epidermisin vivoshows an increase in the number of DNA‐synthesizing cells and mitoses, the published data fromin vitrostudies disagree as to whether or not psoriatic epidermal cellsin vitroare more proliferative than normal epidermal cells. In this study, DNA synthesis was measured autoradiographically using cultured epidermal cells from both the involved and uninvolved skin of 8 psoriatic patients as well as from 8 normal individuals. Our results showed no statistically significant differences in DNA synthesis among the three group

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02576.x

年代:1981

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02577.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTThree cases of prurigo pigmentosa are presented. These patients had episodes of recurring pruritic red papules and gross reticular pigmentation, and responded remarkably to 4,4'‐diaminodiphenyl sulfone (DDS) or sulfisomezole. The possibility was suggested that this dermatosis is due to allergic reactions to substances similar in chemical structure to sulfonamide

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02578.x

年代:1981

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02579.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTA case of cold urticaria showing a positive Prausnitz‐Küstner (P‐K) reaction was studied. The results obtained were as follows: 1) the P‐K reaction was positive, 2) skin fixation time was 21 days, 3) the P‐K reaction could be blocked by heating the serum for 2 hours at 56°C, and 4) the P‐K reaction became negative after adsorption of IgE from the serum. These data suggest that the serum factor responsible for cold urticaria in this case belongs to the IgE class. The effect of histamine liberator 48/80, histological examination of the skin and results of the estimation of serum histamine concentration by a fluorometric method all suggest that this wheal formation is due to a histamine release from mast cells

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02580.x

年代:1981

数据来源: WILEY

摘要:

ABSTRACTTwo cases of congenital onychodysplasia of the index fingers (COIF), one of them with an abnormal range of active motion of the digits, were reported. The characteristic location of a nail, or nails in micronychia and polyonychia of COIF and the involvement of the nail and the bone may be explained by the anatomy of the digit. That is, the radially more pronounced involvement of the nail may be related to the relatively smaller size of the artery of the radial aspect. This may support the transient ischemia theory of Ohta and Haseda (1) in fetal life, though the true etiology of COIF still remains obscure.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1981.tb02581.x

年代:1981

数据来源: WILEY