摘要:

ABSTRACTUntreated rabbits and rabbits sensitized with human β‐lipoproteins were intracutaneously injected with either human or rabbit β‐lipoproteins (2 mg as protein). Forty‐eight hours later, at the human β‐lipoprotein injection site, dense cell infiltrations stood out sharply demarcated from the surrounding region. The infiltrating cells were composed of polymorphonuclear cells, nuclear dust and histiocytes. Foam cell nests were observed in sensitized rabbit dermis one week after human β‐lipoprotein injection. Direct immunofluorescence employing fluorescein isothiocyanate labeled antihuman β‐lipoprotein antiserum showed that the injected human β‐lipoproteins were incorporated into the infiltrating cells of sensitized rabbit dermis up to 48 hours after injection. Specific fluorescence was greatly reduced but lipid autofluorescence remained in mature foam cells. During the 3‐week examination period, no trace of foam cell nests was found at the site of human β‐lipoprotein injection on non‐sensitized rabbits. Intracutaneous rabbit β‐lipoprotein injection revealed no histiocytic infiltrations in either sensitized or non‐sensitized rabbits. These findings indicated that intracutaneously injected human β‐lipoporteins were incorporated into rabbit dermal histiocytes more easily in aggregated immune complex form than in their natural state. These histiocytes were easily transformed to foam cells. Apoproteins of the incorporated lipoproteins were degraded, and lipid residue

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01017.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThree cases of erythropoietic protoporphyria are reviewed. The three patients constitute members of one family. The protoporphyrin content of the red blood cells was high, but porphyrins and their precursors in the urine and faeces were not excessive. Other normal members of the family did not reveal high protoporphyrin content in the red blood cells. Clinical symptoms were itching, swelling, shallow depressed scars and waxy yellow discoloration on the face and brown pigmentation and thickness on the back of the hands after exposure to the sun. The microscopic findings from skin biopsy specimens of the lesions resembled changes of the lipoid proteinosis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01018.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTFifteen patients with pityriasis lichenoides chronica (parapsoriasis guttata) were treated with sunlight irradiation during the summer months at seaside resorts under the supervision of the authors. Complete clearing occurred in 1 of the patients, almost complete clearing in 8, definte improvement in 4, temporary clearing in 2. All patients responded beneficially and no worsening was noted in these 15 cases. In an additional six cases who were instructed to expose themselves to sunlight similar results were obtained.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01019.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA 33‐year‐old male consulted us with symptoms of band‐like infiltration, thickenning and subcutaneous induration occurring in the face, chest, back, shoulder and upper extremities. In the following time he developed arthralgia, fever and ocular symptoms. Laboratory tests revealed normal thyroid functions and a normal bone marrow picture, but there were immunological abnormalities such as reduced cellular immunity, decrease in C 3 (beta 1c/1a) and positive antinuclear antibody. Histologically, there was an increase in fibroblasts and deposits of hyaluronic acid were revealed histochemically. A diagnosis of lichen myxedematosus was established.At present, all symptoms and signs including skin rash have disappeared following corticosteroid therapy and the patient is being followed up. So far as we have been able to trace, reports on lichen myxedematosus associated with immunological abnormalities as described here have not been found. The relationship between this pathology and immunological abnormalities are disc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01020.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThis paper reports a peculiar case seen in a 36‐year‐old woman who every summer since the age of 30 has developed numerous solitary vesicles or crusted papules with intense pruritus in the seborrheic zones. There are no general symptoms and no hereditary relations. The individual rash disappears completely in a week to a month and there is no eruption in winter.The clinical picture resembles that of Darier's disease, but histopathological tests reveal intraepidermal cleft or bulla formation due to acantholysis but no dyskeratosis. Clinicopathological consideration indicates a disease akin to familial benign chronic pemphigus, but as our case does not correspond to any known disease, it is therefore reported as a peculiar acantholytic dermato

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01021.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA patient, aged 78, with exfoliative dermatitis due to the ingestion of Chinese herbs (decoction) was presented. Provocative medication showed that he was sensitive to 4 composite materials (Radix angelicae acutilobae, Rhizoma zingiberis, Radix paeoniae and Radix glycyrrhizae). Patch tests were positive to each of these materials while the intradermal test was negative. These results indicate that systemic contact‐type hypersensitivity to the ingested medicines is involved in evoking the exfoliative dermatitis lesion and that, in addition, purely epidermal contact sensitivity as defined by S. Epstein and Baer plays an important rol

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01022.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA patient with multiple nodules on the chin and scalp is presented. Histologically, the nodules were composed of amorphous materials which also completely filled up the whole dermis. Histochemical observation indicated that the amorphous material in the nodule was a kind of glycoprotein. Electron microscopic examination revealed that the material consists of short wavy fibrils, 60 to 100 A in diameter, and of a low electron‐dense amorphous substance. Biochemical examination supported the view that the amorphous material is so‐called sialomucoid. The nodules were finally diagnosed as colloid degeneration of the skin (nodular ty

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01023.x

年代:1977

数据来源: WILEY