ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03722.x

年代:1992

数据来源: WILEY

摘要:

AbstractSkin lesions of erythema multiforme show time‐dependent changes from early papular erythema to the late target lesion which consists of a peripheral elevated erythematous area and a central depressed area. We investigated the pathomechanism of erythema multiforme, by examining the papular erythema and target lesion separately. In the early papular erythema, a small number of polymorphonuclear leukocytes and nuclear debris were seen intermingled with mononuclear cells around the slightly swollen blood vessels, on which immunoglobulin and complement components were deposited. Circulating immune complex levels were occasionally elevated. Sera from the patients generated high levels of reactive oxygen species and nitroblue tetrazolium test revealed positive reaction on the infiltrating cells around the blood vessels. These findings suggest that the papular erythema developsviaincomplete type III allergic reaction, followed by damage through reactive oxygen species. In the target lesion, the activity of histamine‐N‐methyltransferase, which is the major histamine‐degrading enzyme, was markedly decreased in the peripheral elevated erythematous area and it was recovering in the central clearing area. ICAM‐1 and HLA‐DR antigens were expressed on the surfaces of the keratinocytes. An increased number of epidermal Langerhans cells and CD4 cell infiltration were observed in the peripheral elevated erythematous area, while a decreased number of epidermal Langerhans cells and CD8 cell infiltration in the central depressed area were observed. These findings suggest that impaired histamine metabolism and cellular allergic reactions play important roles in the development of the ta

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03723.x

年代:1992

数据来源: WILEY

摘要:

AbstractDisseminated maculopapular eruptions were frequently observed in a volunteer trial of cefclidin's use in ophthalmological and neurological examinations (8/12; 67%). It appeared at 8–12 days (mean ± SD, 9.6 ±1.1 days) from the initiation of the trial and subsided within 1–2 days (mean ± SD, 1.8 ± 0.4 days). Patch testing with cefclidin produced a ± reaction in 1 of 8 cases, and the drug‐induced lymphocyte stimulation test (DLST) elicited a positive response (SI: 2.8) in 1 of 8 and a weakly positive response (1.8≦SI<2) in 2 of 8. From these findings, it seems likely that the eruptions may be partially mediated by delayed type hypersensitivity (DTH) reactions to cefclidin. No such eruption was observed in the phase II trial of cefclidin where only 2.8% of 1.122 volunteers developed the eruption. The volunteers were given both fluorescein and oxybuprocain in their eyes to measure ocular tension on days –1, 0, 1, 3, 5, 7, 9, 11, 13 and weeks 3, 5, 7 after the initiation of cefclidin. Fluorescein and/or oxybuprocain may affect cefclidin to induce these abnormal reactions in

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03724.x

年代:1992

数据来源: WILEY

摘要:

AbstractHealthy volunteers, who were receiving intravenous injections of cefclidin (CFCL) with frequent concomitant use of fluorescein (F) and oxybuprocain (O) in the eyes for measurement of ocular tension, developed drug eruptions at the high frequency of 66.7%. The injection of CFCL alone induced the eruptions at an incidence of 2.8%. The cause of this high eruption rate was thought to be the simultaneous treatment with F and/or O. Therefore, we conducted experiments with CFCL‐induced generalized rash (GR) in guinea pigs. Guinea pigs treated with F and O during both the phases of immunization and intraperitoneal elicitation developed CFCL rashes at a high frequency. This CFCL‐rash was augmented by the treatment with F during either phase, but not by the treatment with O. Skin testing induced delayed type hypersensitivity (DTH) reaction to O in some animals, but the DTH to F was not induced in animals immunized with F in complete Freund's adjuvant. Furthermore, F augmented rashes induced not only by CFCL but also by other β‐lactam antibiotics such as cefsulodin and sulbenicillin.Accordingly, it is likely that F played a dominant role in the high incidence of drug eruptions during the volunteer trials with measurement of ocular t

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03725.x

年代:1992

数据来源: WILEY

摘要:

AbstractDNA content and cell cycle distributions in paraffin‐embedded blocks of 19 skin biopsy specimens from 17 patients with chronic actinic dermatitis (CAD) [8 patients showed typical actinic reticuloid (AR)] were estimated by DNA cytometry. Sixty‐three percent (12/19) of the skin specimens showed aneuploidy. In the 4 cases with the highest DNA indices (DI), ranging from 1.65 to 1.88 (mean: 1.84), the proportions of cells in S and G2/M phases were increased, ranging from 15–48% (mean: 20%) and from 64–76% (mean: 70.5%), respectively. In 8 cases with DI ranging from 1.15–1.75 (mean: 1.5), the proportion of cells in S‐phase was also increased, ranging from 30–90% (mean: 81.1%). Histologically, it seems likely that the relatively high frequency of aneuploidy, DI, and proportions of cells in the S and/or G2/M phases were not proportional to epidermal or vascular endothelial hyperplasia, but they might be related to dermal lymphoid

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03726.x

年代:1992

数据来源: WILEY

摘要:

AbstractA series of 90 cases of classic Kaposi's sarcoma observed and treated over the last 25 years was examined retrospectively. Fifty‐one were the localized and 39 the disseminated form. Outpatient surgery for the localized and vinblastine chemotherapy for the disseminated form are probably the best treatments. Radiotherapy may be a valid alternativ

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03727.x

年代:1992

数据来源: WILEY

摘要:

AbstractA 24‐year‐old married woman had an angiokeratoma of the vulva measuring 3 × 3 × 4 mm localized at the clitoris. The nodule was noticed when she was pregnant with her first child. This tumor grew with occasional tenderness and bleeding during pregnancy, but its size did not change after delivery. The growth of this tumor might be attributable to an increase in venous pressure or serum progesterone levels; therefore this disorder might be classified as a subtype of angiokeratoma of the vulva. This is the first case of angiokeratoma localized at the cli

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03728.x

年代:1992

数据来源: WILEY

摘要:

AbstractA granulomatous lesion of the lips caused by UVB‐photosensitivity is described. A 31‐year‐old Japanese man developed depigmented, swollen, erythematous lips with some erosions and bloody crusts which were present for 11 months. Histologic examination revealed a dense dermal infiltration composed mainly of lymphoid‐histiocytic cells. Suprabasal clefts were associated with the invasion of lymphoid cells around them. Results of patch and photopatch testing were negative. The minimal erythema dose 24 h after irradiation was lower than normal, ranging from 295 to 330 nm. The lesion was reproduced by repeated irradiation with monochromatic light of 310 and 320 nm, but not by exposure to 250, 260, 270, 280, 290, 300, or 330 nm. Topical injection of glucocorticoids and application of sunscreen led to improvement We propose the name “actinic cheilitis granulomatosa” fo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03729.x

年代:1992

数据来源: WILEY

摘要:

AbstractA 48‐year‐old Japanese woman presented with many subcutaneous nodules. The skin was purplish in color and tender; the nodules were scattered over the entire surface. Histological findings of biopsy specimens from the nodules indicated septal panniculitis comprised of histiocyte and/or macrophage infiltrates, often with erythro‐ and/or leukophagocytosis. Phagocytic cells were OKM1 (CD11b), MT1 (CD43), LeuM3 (CD14), and histiocyte antigen positive, indicating the presence of histiocytes and/or macrophages. The patient had sicca symptoms, positive homogenous, speckled pattern ANA (×320), and diffuse proliferative lupus nep

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03730.x

年代:1992

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03731.x

年代:1992

数据来源: WILEY