ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01892.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTWhen vitiligo occurred on lesions of the pigmented nevus, the behavior of pigment cells in this nevus was investigated. Three cases of giant hairy nevi, seven cases of moles, three cases of Mongolian spots and eleven specimens in nine cases of halo nevi were used. Giant hairy nevi combining with vitiligo showed intensive decreases in nevus cells, particularly superficial A and B‐type nevus cells. The epidermal dopa‐positive melanocytes and melanin granules in the epidermis decreased, but still remained. On the other hand, moles in vitiligo showed an almost complete disappearance of epidermal dopa‐positive melanocytes and melanin granules in the epidermis; nevus cells in the dermis decreased only slightly. Mongolian spots with vitiligo showed an epidermis similar to vitiligo, but the dermal melanocytes were hardly changed. Halo nevi exhibited an intensive decrease and degeneration of nevus cells and marked lymphocytic infiltration. Some of them showed disappearance of epidermal dopa‐positive melanocytes and melanin granules in the epidermis.The characteristic findings of vitiliginous skin are mostly restricted to epidermis. In contrast, however, it is interesting to note that, on the lesions of nevocellular nevi with vitiligo, the dermis also exhibited some decrease and degeneration of nevus cells and lymphocytic infil

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01893.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe ultrastructure of the plasma membrane of human keratinocytes was investigated by freeze‐fracture electron microscopy. Desmosomes were identified as an intramembranous particle aggregation on both of the fracture faces of the plasma membrane. The particle density of desmosomes ranged from 1,100 to 1,500/μ2, while those of the P and E faces of the non‐desmosomal membrane areas were 350 and 100/μ2, respectively. The size of desmosomes varied from 0.3 to 0.7μin diameter. The frequency of the desmosomes was one to two per 2μ2. Gap junctions were a hexagonal array of the intramembranous particles in freeze‐fracture replicas, and found much less frequently than desmosomes. On the basal cell membranes, round pits due to pinocytosis and particle aggregates of hemidesmosomes were

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01894.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTUltrastructural studies were carried out on the patient who developed lichen amyloidosus and Riehl's melanosis‐like lesion on the legs and face, respectively. In the skin specimens from the face, there were many masses of aggregations of wavy or net‐like filaments which appeared to correspond to Civatte bodies as recognized under the light microscope at the dermo‐epidermal junction. Sometimes, an other kind of filament mass was present in the papilla. These were aggregations of straight and non‐branching filaments and were very similar to so‐called amyloid masses. These amyloid‐like masses, which seemed to be in a developmental stage, consisted of net‐like filaments as well as straight and non‐branching filaments. Therefore, the net‐like filament masses or Civatte bodies seemed to serve a particular role in the formation of these amyloid‐like filament masses. On the other hand, in the skin specimens from the leg, there were many amyloid masses in the papillae and few Civatte bodies in the dermo‐epidermal junction, but no features suggesting that Civatte bodies may serve a role in the formation of amyloid. From these observations, it may be concluded that Civatte bodies will contribute to the formation of amyloid under certain conditions like Riehl's melanosis; however, it is still uncertain whether Civatte bodies also contribute to the formation of amyloid filaments

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01895.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe morphology inin vitroprepared immune complexes (I.C.) using horseradish peroxidase as antigen and their behavior in the skin of rabbits were observed under the light microscope. Bothin vitroandin vivo, solubilized I.C. were demonstrated as fine granular substances, while insoluble I.C. were shown to be lumpy or large granular aggregates. Solubilized I.C. injected into the skin disappeared quickly from the skin without being accompanied by the infiltration of polymorphonuclear leucocytes (PMN). Insoluble I.C. stayed in the skin longer and were phagocytosed by infiltrated mononuclear cells and PMN. Macroscopically, the former caused only slight skin edema, but the latter caused severe edema and erythema followed by induration, and also, occasionally, by necrosis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01896.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTA case of a 45 year old woman with multiple subcutaneous nodules and systemic lupus erythematosus‐like symptoms is reported. Histologically the nodules were identical to sclerosing lipogranuloma. The oily substance within the nodules was suspected to be due to depot penicillin injected ten years before. The patient was treated with corticosteroids and finally died of pulmonary fibrosis. This case may be included in the entity of adjuvant diseases of ma

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01897.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTAn 11‐year‐old girl and her 7‐year‐old sister, both with guttate psoriasis, both showed chronic tonsillitis and proteinuria. The ASO titer of the elder sister was 480 units and that of the younger sister 320 units. Tonsillectomies were performed on both sisters because they developed guttate psoriasis after colds with severe sore throats and proteinuria. Skin lesions improved markedly and proteinuria disappeared, but ASO titers did not change significantly. HLA studies were made of the sisters and their parents; A1 and B37 were confirmed in both sisters and their

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01898.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe dermal glycosaminoglycan (GAG) content of rats was measured quantitatively after plucking hair from the backs of the animals, which reinitiates their hair cycle. Mast cells present around the hair follicles were counted at each stage of the hair cycle and compared with the amount of GAG in the skin.GAG reached its peak on the 6th day of the anagen stage and decreased during the catagen stage. In the telogen stage, it was about the same as it had been in the catagen stage. The same pattern was noted for the number of mast cells. The 0.5 M fraction in Dowex‐1 column chromatography proved to be hyaluronic acid and its concentration throughout the hair growth cycle showed strong parallels to that of total dermal GA

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01899.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTComplement fixing antibody to varicella‐zoster virus was studied in sera from 619 persons not suffering from varicella or herpes zoster.The average incidence of the antibody was 23%. There were three points of the high incidence of the antibody, observed in the 10–14, 36–39 and over 60 years age groups which corresponds well to the frequency of varicella and herpes zoster found in or near the above g

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01900.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01901.x

年代:1979

数据来源: WILEY