ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01305.x

年代:1993

数据来源: WILEY

摘要:

AbstractAdenosine deaminase is one of the key enzymes in purine nucleotide degradation. This enzyme exists in most of the human tissues and the activity is high in lymphatic tissues, especially in T lymphocytes. Elevated adenosine deaminase activity in T cell leukemia has been reported, and its inhibitor, deoxycoformycin, has been developed as an antitumor agent. In some types of leukemia, serum adenosine deaminase activity increases in accordance with the severity of the disease. Although mycosis fungoides rarely involves peripheral blood, tumor cells do invade the skin. In order to evaluate the clinical significance of adenosine deaminase in mycosis fungoides, adenosine deaminase activity was measured in sera of 15 patients with mycosis fungoides at various stages. The mean enzyme activity was 23.2 IU/l, which was high with statistical significance compared with healthy controls (P<0.001). Nine of twelve patients in the plaque stage (T2N0M0, IB) showed higher adenosine deaminase activity than did the normal population. The mean adenosine deaminase activity in sera in the patients in the plaque stage (T2N0M0, IB) was as high as 19.0 IU/l (range 13.7–21.4) with statistical significance compared with healthy control (P<0.001). Three tumor stage patients without visceral involvement (T3N0M0, IIB) showed higher levels of adenosine deaminase activity (19.7, 21.5, 24.4 IU/l). An erythrodermic patient (T4N0M0, III) also had a high adenosine deaminase activity 28.4 IU/l. Two tumor stage patients with organ involvement (T3N0M1, IVB) exhibited extremely high adenosine deaminase activity (60.9, 32.2 IU/l). The adenosine deaminase activity in sera showed a tendency to become higher with the extension of the stages. From the results obtained in this study, it is suggested that serum adenosine deaminase activity may reflect the tumor progress in mycosis fungoide

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01306.x

年代:1993

数据来源: WILEY

摘要:

AbstractBiopsied specimens from skin lesions of SLE were studied for expression of 70 KD heat shock protein (HSP70). The pattern of HSP70 expression in SLE was diffuse in whole epidermis, hair follicles, and sweat gland cells and rather more intense than that in other control groups or normal skin. No significant differences in HSP70 expression were observed between sun‐exposed and protected areas of SLE skin lesions. Unlike SLE, reduced or no expression of HSP70 was observed in skin lesions of DLE. In tissue culture, UVB radiationin vitroinduced relatively intense expression of HSP70 in the nuclear area of keratinocytes. A fewγδT cell receptor positive cells which might respond to HSP70 expressing cells were detected in the basal layer of skin lesions of diseases.These studies suggest that abberant expression of HSP70 in skin lesions of SLE might contribute to both skin lesions and antibody formation in

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01307.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 67‐year‐old woman with a left‐sided hemiplegia had localized bullous pemphigoid demonstrating typical clinical lesions on the left pretibial skin and the radial‐side skin of the right forearm. The histology showed a subepidermal blister with extensive hyperkeratosis, hypergranulosis, and acanthosis. Direct immunofluorescence revealed distinct linear deposits of IgG and C3 at the dermo‐epidermal junction in the perilesional skin and in the roof of the blisters, but few deposits in nonlesional skin. Electron microscopy revealed separation in the lamina lucida. Indirect immunofluorescence of type VII collagen showed its localization in the blister floor. The distribution of the 180‐KD bullous pemphigoid antigen (BPA) andβ4 integrin, hemidesmosomal transmembrane proteins, were studied in the lesional skin by indirect immunofluorescence. Both 180‐KD BPA andβ4 integrin were localized in the blister roof. By immunoelectron microscopy,β4 integrin was detected in small groups on the cell surface facing the blister cavity. Since the epitope of the monoclonal antibody to 180‐KD BPA used here is known to be localized at a distance of 20 to 50 nm from the membrane surface and this epitope retained in the blister roof, it appears that the blister was produced in the deep lamina lucida. The lesions were cleared with topical 0.05% clobetasole p

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01308.x

年代:1993

数据来源: WILEY

摘要:

AbstractAn ultrastructural and morphometric study compared Langerhans' cells in sacral epidermis, 8–10 cm from the lesion of patients (mean age 70) with decubital ulcers, with those in the patients' own normal epidermis from the upper leg and with those in the epidermis from the upper leg of normal age‐matched volunteers. The Langerhans' cell section area was significantly lower in patients' control leg epidermis (25.86 ± 2.29μm2) than in that from normal controls (35.74 ± 3.76μm2) or that from patients' sacral epidermis near the lesion (41.26 ± 3.45). The number of Langerhans' cell granules was higher in control leg epidermis of patients (10.22 ± 1.26) and was significantly higher in lesioned sacral epidermis (12.94 ± 1.90) than in normal controls (6.97 ± 1.47). In Langerhans' cells in patients' epidermis, formative stages of Langerhans' cell granules were observed. The findings may indicate that Langerhans' cells in patients' epidermis are in an a

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01309.x

年代:1993

数据来源: WILEY

摘要:

AbstractA patient with a 46‐year history of vitiligo who also presented rheumatoid arthritis and pernicious anemia is described. Meticulous physical examination excluded further systemic or cutaneous involvement. The immunological workup revealed a low CD4cell percentage with T cells mostly composed of CD8cells, a discrepancy between the high percentage of cumulative CD4+ CD8cells and the measured CD3proportions, very low NK cytotoxicity toward K562cells, and almost negligible responses to PHA, Con A and PWM mitogens. The results point to severe T and NK cell functional defects. The pathogenetic significance of these data is discusse

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01310.x

年代:1993

数据来源: WILEY

摘要:

AbstractA case of cactus granuloma due to the thorns of Opuntia bieglovii Engelman is reported. A 24‐year‐old Japanese man contacted the thorns of this cactus in Palm Springs, California, U.S.A., and, three months later, numerous, slightly elevated papules 2 to 4 mm in diameter appeared on the dorsum of his right hand and fingers. Histopathological examination revealed many small granulomas surrounding the bristle fragments throughout the dermis. The granulomas consisted of epithelioid cells, Langhans type and foreign body type giant cells. The fragments of the barbed bristles gave strongly positive reactions with PAS. Two hypothetical mechanisms, one allergic and the other non‐allergic, are offered to explain this granuloma formation and are discussed with reference to the liter

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01311.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 65‐year‐old Japanese male, who was treated for Fournier's gangrene, developed an enlarged erythema over the right thigh and right lower quadrant. The area was surgically debrided, and he was given antibiotics. However, he complained of abdominal swelling with a metallic bowel sound, pain, and vomiting and was then treated for paralytic ileus. Although his symptoms initially improved, he complained again of the same symptoms and underwent surgery for mechanical ileus occurring at the site of a surgical scar from an appendectomy 43 years earlier.This is a very rare case of Fournier's gangrene which caused mechanical ileus of the small intestine and adherence to a peritoneal scar after paralytic ileus due to inflammation of the abdominal fascia following scrotal gangr

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01312.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 60‐year‐old woman with superficial spreading melanomain situ, measuring 2.5 mm in diameter, was examined. She had noticed a very small pigmented lesion 1.2 mm in diameter on her left lower leg in April of 1989. By April of 1990, it had grown to 2.5 mm in diameter. Its edge was irregular, and its color was variegated black to brown. Skin surface markings had disappeared in the center portion. Histopathologically, the lesion was asymmetrical. Atypical large cells nested in the lower epidermis and were scattered singly in the mid and upper epidermis, as seen in Paget's disease. At the periphery of the lesion, single large tumor cells were scattered in the mid epidermis. The tumor cells reacted to monoclonal anti‐melanoma antibody H

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01313.x

年代:1993

数据来源: WILEY

摘要:

AbstractAlthough penicillin still remains highly effective for syphilis, concerns have been raised that current regimens may be inadequate for the treatment of early syphilis. We report the failure of benzathine penicillin in the treatment of secondary syphilis. Extensive tracing of sexual contact history failed to identify sources of possible reinfection; therefore, we believe that this case represents a treatment failure and an ensuing relapse of secondary syphilis.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb01314.x

年代:1993

数据来源: WILEY