摘要:

AbstractThe effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet‐B (UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 μmol), PUVA‐induced ODC activity was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB‐induced ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by different pa

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03246.x

年代:1992

数据来源: WILEY

摘要:

AbstractBy scanning (SEM) and transmission electron microscopy (TEM), we evaluated the infiltrated eosinophils in lesions at various stages of clinical development from patients with bullous pemphigoid (BP) and eosinophilia. Visualized by SEM, numerous inflammatory cells migrated through the cutaneous basement membrane into the cavity of newly formed blisters 12 to 24 hrs after formation. Many migrating cells attached to the reverse side of the bullous cavity, and some basal cells shed into the cavity. As the bullae developed 24 to 48 hrs after formation, the reverse surface of the bullous cavity became predominantly composed of these migrating cells and the exposed squamous cells. The migrating cells had villi, ruffles and ridge‐like profiles on their surfaces, which were suggested eosinophils. By TEM in the same lesions, many morphologically activated eosinophils were seen to have passed through the basement membrane into the newly formed blisters; they exhibited spheroidal cytoplasmic granules with less dense crystalloid cores and intracellular channels. Eosinophils infiltrating in the developed bullous cavity directly adhered to basal cells and released their granule contents onto these target cells. These findings suggest that inflammatory cells, especially eosinophils, may amplify the formation of dermalepidermal separation in BP lesion

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03247.x

年代:1992

数据来源: WILEY

摘要:

AbstractMany procedures to correct ingrown toenails are available; however, they cannot avoid recurrence and nail deformities. We have performed a procedure which corrects ingrown toenail without reducing the width of the nail plate by elevating the nail bed‐periosteal flap. Sixty patients were observed for longer than six months and exhibited excellent results. Only two cases of incurvated nails (2) required re‐operat

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03248.x

年代:1992

数据来源: WILEY

摘要:

AbstractIn order to evaluate the hormonal milieu in young men with severe acne, we measured serum estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydro‐epiandrosterone sulfate (DHEA‐S), and sex hormone binding globulin (SHBG) levels in sixteen male patients aged 20–30 years with severe acne, including twelve cases of nodular‐cystic acne, and in seventeen age‐matched normal controls.There were no significant differences in the serum levels of T, FT, DHT, DHEA‐S, or SHBG between the patients and the controls, but serum E2was significantly higher in the patient population.Thus, the hemodynamics of serum androgens in male patients with acne do not seem to differ significantly from that of normal controls. Elevated E2levels might affect the inflammatory response of acne vulgaris through the release of thymic hormones, as reported in the

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03249.x

年代:1992

数据来源: WILEY

摘要:

AbstractWe investigated populations of the infiltrating cells in Bowen's disease (BD) and squamous cell carcinoma (SCC), both of which arose in the same patient, using the Avidin‐Biotin‐peroxidase complex method with eight monoclonal antibodies. T lymphocytes were most predominant among infiltrating cells; NK cells, B cells, and monocytes were rarely seen in either BD or SCC. Analysis of subsets of the infiltrating T lymphocytes revealed that the number of suppressor/cytotoxic (s/c) T cells was twice that of helper/inducer (h/i) T cells in BD, while the number of s/c T cells was lower than that of h/i T cells in SCC. The immunohistochemical results in the present case differed from those of predominant infiltration of h/i T cells and of s/c T cells in three other reports of BD and SCC.These results suggest that the population of the cellular infiltrates may be modulated by the nature of tumors and by the immuno‐competent state of the

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03250.x

年代:1992

数据来源: WILEY

摘要:

AbstractLichen planus annularis is a relatively rare skin manifestation of lichen planus. The mechanisms in the formation of annular lesions are not fully understood. We reported here a 57‐year‐old female with this disease. The eruption initially occurred as lichen‐papules, then enlarged (bean‐sized, umbilicated small plaques), and finally developed annular manifestations. We performed immunohistochemical examinations of specimens taken from different types of eruptions.In all specimens, HLA‐DR was expressed in the focal keratinocytes adjacent to the dermal HLA‐DR positive cell infiltration. Both in the initial papule and in the final annular lesion, expression of ICAM‐1 was present only in the keratinocytes above the dermal cell infiltration, similar to HLA‐DR. It is of interest that, in the umbilicated small plaques, the peripheral epidermis other than the central site extensively reacted to ICAM‐1. LFA‐1 expression was most prominent in the mononuclear cells impinging on the dermo‐epidermal junction in all specimens. In addition, in the periphery of the umbilicated small plaques, which showed no bandlike dense cell infiltration nor degeneration of basement membrane, TNF‐alpha, but not LFA‐1, was positive in the infiltrated cells of the upper dermis.These results suggest that expressions of ICAM‐1 and TNF‐alpha in the peripheral keratinocytes and dermal infiltrated cells are important molecular events in the mechanisms of for

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03251.x

年代:1992

数据来源: WILEY

摘要:

AbstractA 69‐year‐old Japanese woman with erythema, severe edema on the face, Gottron's papules and poikiloderma was diagnosed as having dermatomyositis. She also noticed muscle weakness in her extremities, although her electromyogram showed neurogenic patterns. Her levels of CA19‐9 and CEA were elevated and a CT of her abdomen revealed a giant, multilobular, cystic lesion in the pelvis. This tumor was diagnosed as pseudomyxoma peritonei originating from a mucinous adenocarcinoma of the app

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03252.x

年代:1992

数据来源: WILEY

摘要:

AbstractDermatomyositis developed suddenly in a diabetic patient with CREST syndrome after the removal of a malignant tumor. Scrupulous physical examination excluded further systemic or cutaneous involvement. We raise certain still unsolved aspects regarding the association between dermatomyositis and neoplastic disorders.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03253.x

年代:1992

数据来源: WILEY

摘要:

AbstractWe used fasting diet therapy with a 28‐year‐old woman with chronic urticaria who responded only to systemic administration of glucocorticosteroids. The rashes began to decrease on the third therapeutic day and completely disappeared on the 11th day. Although the eruptions relapsed three days after the termination of the therapy, they were milder than previous ones. We also discussed the possible efficacy of fasting diet therapy for chronic urticaria as reported in the literat

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03254.x

年代:1992

数据来源: WILEY

摘要:

AbstractA giant condyloma acuminatum developed on the penis of a one and a half‐year‐old Japanese boy in two months. The histological features of this tumor were compatible with those of ordinary condyloma acuminatum. Although we detected the presence of human papilloma virus (HPV) type 16 by using the polymerase chain reaction system, we could not rule out the possibility that this HPV was present concurrently with other HPV types that cause condyloma acuminatum. The lesion was successfully treated with cryotherapy and topical application of 5% fluorouracil ointment under occlu

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1992.tb03255.x

年代:1992

数据来源: WILEY