摘要:

AbstractWe sent questionnaires to the major dermatological institutions in Japan concerning the course and associations of dermatomyositis (DM). Of 637 cases observed between 1973 and 1983, 68 were children. The mortality rate was 2.9% in children, 47.1% in adult males, and 30.0% in adult females. Associations with malignancies were noted in 30.1% of adults; 112 cases (19.7% of adults) died from these, but surgery improved the signs of DM in 22 cases. The main neoplasms were cancer of the stomach, lung, colon, and breast. Association with pulmonary fibrosis (PF) was observed in 85 cases (14.9% of adults) and, in spite of intensive treatment, 38 cases (6.7%) died from it. In the majority of PF cases who died within 2 months, pulmonary symptoms started within 6 months of the onset of DM. All cases of PF which occurred before the onset of DM survived. The concurrence of PF and malignancies was exceptional. Death from myocardial disease occurred in only 3 cases.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02935.x

年代:1986

数据来源: WILEY

摘要:

AbstractA method for maintaining the epidermal structures of the normal human and uninvolved and involved psoriatic skin explants in organ culture was described. Skin explants were put in diffusion chambers made of millipore filters, which were then submitted to a roller tube culture at 15 rpm and 32°C. With a gas phase of air + 5% CO2(phase A), both normal and psoriatic skin explants in culture showed parakeratosis or degeneration of their epidermal cells; with a gas phase of either 50% O2+ 45% N2+ 5% CO2(phase B) or 95% O2+ 5% CO2(phase C), they showed neither parakeratosis nor degeneration of epidermal cells and maintained their original structures for 14 days. Autoradiographically, the number of thymidine‐3H (3H‐TdR) labeled epidermal cells in organ culture was greater in involved psoriatic skin explants than in uninvolved ones. Isoproterenol‐stimulated cyclic AMP (cAMP) levels were lower in involved psoriatic epidermis of skin explants than in uninvolved ones, and plasminogen activator activity was higher in the former than in the latter. Addition of dexamethasone normalized the keratinization of the involved psoriatic explant in culture, but addition of dibutyryl cyclic AMP (db cAMP) and dibutyryl cyclic GMP (db cGMP) d

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02936.x

年代:1986

数据来源: WILEY

摘要:

AbstractInterrelationships between biliary dyskinesia and chronic urticaria, chronic eczema and atopic dermatitis have been studied in 210 biliary dyskinesia patients and 60 normal subjects. Incidences of chronic urticaria, chronic eczema and atopic dermatitis were found more frequently in biliary dyskinesia patients than normal subjects.Skin symptoms of these chronic urticaria, chronic eczema and atopic dermatitis cases showed significant normalization with improved gallbladder contraction rate. COMT inhibitor therapy and fat restriction were more effective for the skin symptoms and for prolonging the interval before recidivation or exacerbation of these allergic diseases than conservative therapy.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02937.x

年代:1986

数据来源: WILEY

摘要:

AbstractIn order to study the pathogenetic role of anti‐basement membrane zone antibodies (BMZ‐Ab) in bullous pemphigoid (BP), parenteral transfer of serum, heat inactivated serum, blister fluid, or IgG from three patients with BP into neonatal mice was carried out. BP‐like lesions developed in 6 of 8 mice receiving the serum from one of the patients. However, no lesions were observed in 100 other mice that were given serum, blister fluid or IgG from the other two patients or three healthy controls. Analysis of the characteristics of these injected materials revealed that, for induction of the BP‐like lesions in neonatal mice, it is necessary that both complement‐fixing BMZ‐Ab and components of complement are present. The role of inflammatory cells in the pathogenesis of BP could not be determined by the present

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02938.x

年代:1986

数据来源: WILEY

摘要:

AbstractWe measured C5a and C5a des arg (collectively called C5a) by radioimmunoassay in the sera of psoriasis and other widespread inflammatory dermatoses. Larger amounts of serum C5a were detected in patients with psoriasis and other inflammatory dermatoses than in normal healthy controls. In the psoriatic patients, the serum C5a concentrations did not correlate with extent or with activity of the skin lesions. However, when followed in 6 psoriatic patients, the C5a levels showed changes in parallel with the skin lesions. Our results suggest that complement activation with resultant release of C5a anaphylatoxin takes place in psoriasis as well as in other widespread inflammatory skin disorders.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02939.x

年代:1986

数据来源: WILEY

摘要:

AbstractSarcoidosis sera were shown to have higher activity in aggregating normal human monocytes than normal human sera. A kinetic study suggested that monocytes may not be sensitive to the aggregating activity of sarcoidosis serum until they develop to some extent into macrophages. Gel filtration of sarcoidosis sera on Sephadex G‐200 showed that the major factor responsible for monocyte aggregation had the molecular weight of about 130,000. This major aggregating factor was unable to increase cell size of normal human monocytes or to increase phagocytosis and glucose consumption of normal human monocytes. It did have the ability to form multinucleate giant cell

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02940.x

年代:1986

数据来源: WILEY

摘要:

AbstractA case of amyloidosis cutis nodularis atrophicans (ACNA) was reported. The characteristics of the amyloid deposit were examined using the unlabeled immunoperxoidase method (peroxidase‐antiperoxidase method, so called PAP). The study revealed that the amyloid deposit contained A type protein AL, and the surrounding plasma cells containedλandκtypes of both immunoglobulin light chains and Bence Jones protein, with strong preference toward theλtype of each protein. These results suggest that, in ACNA, the plasma cells produce and secrete immunoglobulin light chains and/or Bence Jones protein, and that the protein degenerates into protein AL and then accumulates in the tissue to form nodules. ACNA seems to be a localized form of AL type amyloidosis, since patients with ACNA have no signs of systemic involve

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02941.x

年代:1986

数据来源: WILEY

摘要:

AbstractA case of eccrine tubular adenoma on the dorsum of the right foot is presented. Histopathologically, in the central nodule of the tumor, the whole dermis was involved and the tumor islands were connected to the epidermis; in the rest of the lesion, tumor islands were observed in the upper dermis. The tumor islands were composed of cystic or alveolar structures and cell masses possessing multiple lumina. Tubules were surrounded by two or more layers of epithelium forming papillations projecting into the lumen. There were only a few basaloid islands and no sclerotic strands. The tumor cells were well differentiated. Acid mucopolysaccharides were seen in the stroma. Histochemically, phosphorylase and acid phosphatase reacted moderately. Succinic dehydrogenase gave a weak reaction andβ‐glucuronidase was negative in tumor cells. Ultrastructurally, intracellular ducts with numerous microvilli, periluminal filamentous zones, and many multivesicular dense bodies surrounded by a limiting membrane were observed. Keratohyalin granules were absent. Based on these findings, the tumor reported here was considered to be an adenoma differentiating toward the eccrine duct. Some aspects resembled tubular apocrine adenoma, syringoma and basal cell tumor with eccrine differentiation, but they were most similar to papillary eccrine adeno

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02942.x

年代:1986

数据来源: WILEY

摘要:

AbstractIn a 64‐year‐old woman, fever, malar rash, widespread macular erythema, polyarthritis, generalized myalgia, and a positive reaction for antinuclear antibody developed while she was taking donperidone (30 mg daily). Proteinuria and hypocomplementemia were not found. The histopathology of cutaneous lesions was almost consistent with that of systemic lupus erythematosus. The lupus band test on the involved skin was weakly positive, but electron microscopy revealed no microtubular structure in the vascular endothelium of the involved skin.After withdrawal of the drug, there was complete resolution of the clinical signs and symptoms. Resumption of the therapy with the drug resulted in recurrence of her symptoms. The patient's antinuclear antibody reaction was weakly positive over a three‐month follow‐up period.To our knowledge, this is the first reported case of a clinical systemic lupus‐like syndrome induced by therapy with do

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02943.x

年代:1986

数据来源: WILEY

摘要:

AbstractAn interesting case of epidermodysplasia verruciformis with a 12‐year‐follow‐up is reported. During the period of observation, the patient developed leprosy (TT), skin tuberculosis, molluscum contagiosum, tinea corporis and condylomata acuminata lesions. Mantoux, lepromin and DNCB sensitization tests for cell mediated immunity (CMI) were negative. The significance of these findings is briefly disc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1986.tb02944.x

年代:1986

数据来源: WILEY