ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01001.x

年代:1977

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01002.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTEighty‐two patients with atopic dermatitis were examined for specific IgE antibodies by RAST. A higher number of positive RAST reactions were found in patients with high serum IgE values and with coexisting asthma and/or allergic rhinitis. Positive RAST reactions against mite and house dust were found in many of these patients and even in about one‐half of patients with atopic dermatitis only. The comparisons between intradermal tests and RAST were made with various allergens and the mite extract showed the best agreement between these two te

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00991.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn a typical case of Darier's disease, intracytoplasmic desmosomes, gap junctions and many vesicles were observed in the cytoplasm of epidermal keratinocytes.Intracytoplasmic desmosomes were found in the cytoplasm of the excessively keratinized cells, vacuolated cells and acantholytic cells. They were not associated with tonofilaments as much as with ordinal intercellular desmosome‐tonofilament complexes, and some of them lacked a central strip and looked similar to the denatured intercellular desmosomes in the morphology of the abnormal keratinocytes of Darier's disease.These intracytoplasmic desmosomes were long and undulating and some of the showed a “tennis racket” image (Caputo).Furthermore, some were combined with the gap junction and the intermediate junction, forming a bounded vesicle in the cyto

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00992.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTUp to the present no other therapeutic means besides local X‐ray or beta‐ray irradiation and anticancer drugs for the treatment of patients with mycosis fungoides, especially when the condition has progressed to secondary involvement of the lymph nodes, has been found.A recent clinical trial of OK‐432 injected locally into cutaneous tumors of a patient with this disease resulted in a conspicuous contraction not only of the tumors injected but of other tumors as well along with significant regression of lymphadenomas. No serious adverse reaction was observed other than low‐grade fever and heavy‐headedness.These results suggest host‐mediated and direct antitumor effects of OK‐432 as the possible underlying mechanisms. The efficacy of OK‐432 in reducing the size of the tumors without causing any serious adverse effects indicate the potential usefulness of this drug for the treatment of my

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00993.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTTyrosinase [EC 1.14.18.1] isolated from mouse melanoma was inactivated during the dopatyrosinase reaction. When ascorbate was added to the reaction system, in which dopa‐quinone is immediately converted back to dopa by ascorbate thus preventing the formation of melanin, tyrosinase inactivation similarly occurred. If superoxide anions (O2–) or singlet oxygens (1O2), are generated during the reaction they can attack the enzyme protein to be inactivated. Therefore an estimate was made with scavengers for oxygen radicals and with a liquid scintillation counter but neither was detectable. Thus the inactivation involved is not due to reaction products nor oxygen radic

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00994.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe number of DNP group‐bearing lymphocytes in the regional lymph node, thoracic duct and peripheral blood was determined at various time intervals after painting normal guinea pigs with DNCB by the immunofluorescent method using anti‐DNP antibody. The incidence of such cells in the regional node was maximal at 12 hours whereas in the thoracic duct and peripheral blood the maximum incidence was found at 0.1–2 hours after painting. Unreacted DNCB was demonstrated in both the thoracic lymph duct and the blood at least for 12 or 24 hours respectively following exposure to DNCB. The authors therefore suggest that DNCB reacts directlyin vivowith the lymphocyte cell membrane of guinea pig following epicutaneous application of the che

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00995.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTTwo brothers with angiolipoma are presented. The patients, 33‐ and 37‐year‐old men, have multiple subcutaneous nodules on the trunk and extremities. Skin biopsies have confirmed the diagnosis of angiol

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00996.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTLesions of atrophie blanche which developed in 2 patients with systemic lupus erythematosus have been followed up for 3 years. The observation was made that atrophie blanche was not always preceded by ulcers but healed directly as scars. It was assumed that atrophie blanche might not be a terminal stage of necrotizing angitis but an intermediate one in the healing process.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00997.x

年代:1977

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb00998.x

年代:1977

数据来源: WILEY