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1. |
Autoantibodies in Scleroderma |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 257-268
Marvin J. Fritzler,
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摘要:
AbstractAutoantibodies directed against nuclear, nucleolar, and a number of cytoplasmic components are described in the sera of scleroderma patients. Early studies of autoantibodies that relied on cryopreserved sections of rodent organ substrates showed that approximately 50% of scleroderma patients had anti‐nuclear antibodies (ANA). More recent studies that have used tissue culture cell substrates have shown that up to 98% of scleroderma patients have a positive ANA. In all of these studies, the presence of different patterns of staining have suggested that scleroderma sera reacted with a variety of intracellular antigens. The use of molecular and immunochemical techniques has now shown that over 20 intracellular autoantigens are targets of autoantibodies in scleroderma sera. Clinical studies have shown that these autoantibodies are important diagnostic and prognostic markers in scleroderma. In the future, autoantibody testing may be used to monitor the patient's response to immunological therapie
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01389.x
年代:1993
数据来源: WILEY
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2. |
Clinical Criteria for Differentiating between Recessive and Dominant Forms of Dystrophic Epidermolysis Bullosa, Elaborated from an Analysis of 119 Cases |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 269-275
Kazuo Nomura,
Takashi Imaizumi,
Takashi Sato,
Isao Hashimoto,
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摘要:
AbstractWe attempted to establish clinical criteria which differentiated between recessive dystrophic epidermolysis bullosa (RDEB) and dominant DEB (DDEB), since these two groups show prominent differences in prognosis, genetic recurrence risk and response to some types of treatment. The total of 119 cases examined consisted of our own 9 cases (2 of RDEB and 7 of DDEB) and 110 cases (26 of RDEB and 84 of DDEB) collected from the medical literature. They were analyzed by calculating the sensitivity and specificity of ten clinical features. We concluded that, syndactyly, presence of complications, dental lesions, remission‐less course, and oral lesions are strongly indicative of RDEB (more than 70% specific). Intractable skin ulcer is suggestive of RDEB (more than 55% specific). Nail lesions, scar and atrophy, milia and pigmentation are not helpful in the differentiation because of their commonality. The proposed criteria are simple, reliable, and practical, providing us with a useful tool for differentiation of RDEB and DDEB in daily practic
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01390.x
年代:1993
数据来源: WILEY
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3. |
An Analysis of 24 Patients with IgA Deposition at the BMZ |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 276-278
Weng Meng‐Wu,
Qiu Bing‐Sen,
Kang Ke‐Fei,
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摘要:
AbstractA study of 24 patients with IgA deposition at the BMZ of the skin showed that five conditions could be recognized: 1) linear IgA bullous dermatosis in adults (LAD, 7 cases); 2) linear IgA and IgG bullous dermatosis in adults (LAGD, 10 cases); 3) chronic bullous disease of childhood (CBDC, 3 cases); 4) dermatitis herpetiformis (DH, 1 case), and 5) systemic lupus erythematosus (SLE, 3 cases). Histopathologically, 5 of 7 patients with LAD were similar to the DH group, but 7 of 10 patients with LAGD were similar to the BP group. Half the patients with LAD and LAGD had oral lesions, and most of them had excellent responses to dapsone and Tripterygium Wilfordii, but the patients with CBDC did not respond to these treatments. In the patients with LAD and LAGD, the positivity rates of IgA anti‐BMZ antibodies examined by indirect immunofluorescence (IIF) on intact skin and NaCl split skin were 41% and 64%, respectively. The heterogeneity of the histopathologic pictures of LAD and LAGD, the incidence of DH, and the value of using NaCl split skin for IIF are discusse
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01391.x
年代:1993
数据来源: WILEY
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4. |
Cutaneous Reactions Induced by Calcium Channel Blocker: High Frequency of Psoriasiform Eruptions |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 279-286
Kazuko Kitamura,
Mugiko Kanasashi,
Chizuka Suga,
Sumi Saito,
Sadao Yoshida,
Zenro Ikezawa,
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摘要:
AbstractFifteen cases with cutaneous reactions to calcium channel blockers (Ca‐antagonist), dihydropiridine (including nicardipine, nifedipine, nisoldipine), verapamil, and diltiazem are reported. The patients from Yokohama City University Hospital and affiliated hospitals included 4 males and 11 females with cardiovascular diseases. Their average age was 64.7 (54 to 82) years. They had been taking Ca‐antagonists for an average of 95 days (7 days to 10 years) before they developed dermatitis. The frequency of reactions to Ca‐antagonists was high with diltiazem (5/16: 31.25%) and dihydropyridine (7/16: 43.75%), including nifedipine (4/7), nisoldipine (1/7), and nicardipine (2/7). Stevens‐Johnson syndrome (MCOS) was associated only with verapamil.A notable type of eruption was the psoriasiform type, including exacerbation of psoriasis, which was resolved or easily controlled after discontinuation of the drug. Provocation tests verified the Ca‐antagonist as the cause in 7 cases of psoriasiform eruption.The frequency of positive patch tests to Ca‐antagonists was low except for diltiazem. Patch tests with diltiazem showed positive reactions in 54% (7 of 13 patients), based on our experience and papers published in Japan.Ca‐antagonists are occasional causes of a wide spectrum of cutaneous reactions and should also be considered as causative factors in patients who develop psoriasiform eruptions or in patients whose psoriasis is exacerbated while usin
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01392.x
年代:1993
数据来源: WILEY
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5. |
A Correlation between Carotenemia and Biliary Dyskinesia |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 287-292
Toshio Nishimura,
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摘要:
AbstractThe interrelationship between carotenemia and biliary dyskinesia was studied in eighty‐two biliary dyskinesia patients and twenty‐seven normal subjects. Incidence of serum carotene levels of more than 300µg/dl was more frequent in biliary dyskinesia patients without liver damage or hyperlipemia. Among the carotenemia patients, no dietary cases were found, but metabolic and hyperlipemic ones were observed. Significant relationships were found between gall bladder contraction rate and the levels of serum carotene, vitamin A, and lipids in metabolic carotenemia. A close relationship between metabolic carotenemia and biliary dyskinesia was strongly sugge
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01393.x
年代:1993
数据来源: WILEY
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6. |
Association of Generalized Granuloma Annulare with Autoantibodies |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 293-297
Joji Tada,
Akemi Seno,
Masumi Ueda,
Jirô Arata,
Yo Nagao,
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摘要:
AbstractGranuloma annulare is a degenerative disease of the skin histopathologically characterized by focal degeneration of collagen with a surrounding infiltrate of lymphoid cells, histiocytic cells, and multinucleated giant cells. Immunological abnormalities such as delayed‐type hypersensitivity and vasculitic origin are suspected in the pathogenesis. We describe three patients with generalized granuloma annulare, in whom autoantibodies, including antinuclear antibody, antithyroid stimulating hormone receptor antibody, and immune complex, were detecte
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01394.x
年代:1993
数据来源: WILEY
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7. |
A Case of Cutaneous B‐cell Lymphoma with a Storiform Stromal Reaction |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 298-303
Tetsuo Nagatani,
Megumi Miyazawa,
Toshiko Matsuzaki,
Gaijiro Iemoto,
Shu‐Taku Kim,
Naoko Baba,
Hideaki Miyamoto,
Hiroshi Nakajima,
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摘要:
AbstractA case of cutaneous B‐cell lymphoma is described. The patient was treated only by surgical excision of the skin tumors five times during a period of about two years from February of 1984 to October of 1986. After the last surgical excision, a continuous disease‐free period was achieved. Biopsy samples showed dense lymphocytic infiltrations with discrete masses in the dermis and subcutis; one of them showed a storiform pattern. At the time, the infiltrating cells were composed of medium and large lymphoid cells and spindle‐shaped cells. The medium and large lymphoid cells were positive for CD20, CD22 and HLA‐DR and negative for CD3, CD4, CD5, CD8, CD43, and kappa and lambda light chain. The spindle‐shaped cells were negative for CD20, CD43, kappa and lambda light chain, lysozyme, and S‐
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01395.x
年代:1993
数据来源: WILEY
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8. |
A Case of Necrobiosis Lipoidica Treated with Systemic Corticosteroid |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 304-307
Yoshiki Taniguchi,
Takayoshi Sakamoto,
Masayuki Shimizu,
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摘要:
AbstractA 43‐year‐old woman had asymptomatic eruptions on the anterior sides of both legs for 5 years. Biopsy specimens revealed the typical findings of necrobiosis lipoidica. An immunofluorescence study demonstrated no deposits of immunoglobulins, complement, or fibrinogen in vessel walls. Immunohistochemical staining revealed CD4 positive lymphocytes dominating in the lesion and strong expression of ICAM‐l on the endothelial cells, giant cells, lymphocytes and dermal fibroblasts in the lesion. The eruptions resolved remarkably with oral corticosteroid th
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01396.x
年代:1993
数据来源: WILEY
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9. |
Familial Cases of Psoriasis Vulgaris and Pustulosis Palmaris et Plantaris |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 308-310
Yukari Matsuoka,
Natsuko Okada,
Kunihiko Yoshikawa,
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摘要:
AbstractTwo familial cases of psoriasis vulgaris and pustulosis palmaris et plantaris and their HLA types were examined. Our cases suggest a close genetic relationship between these two diseases.
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01397.x
年代:1993
数据来源: WILEY
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10. |
Papillary Tubular Adenoma of the Skin |
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The Journal of Dermatology,
Volume 20,
Issue 5,
1993,
Page 311-313
Catherine N. Makunura,
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摘要:
AbstractA case of papillary tubular adenoma of the skin in a 31‐year‐old black man is reported. This lesion is also termed papillary eccrine adenoma, and it commonly occurs in the extremit
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1993.tb01398.x
年代:1993
数据来源: WILEY
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