ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01934.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01935.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01923.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe validity of the buffy coat leucocyte aggregation (BCLA) test was studied. We found that the test was highly specific and reproducible. At the same time, the degree of aggregation in the presence of tuberculin Purified Protein Derivative (PPD) correlated well with the diameter of the skin test response to that antigen. The leucocytes in the buffy coat of penicillin sensitive subjects were not aggregated with the addition of sodium penicillin antigen, indicating that the test was unable to differentiate penicillin sensitive from penicillin insensitive subjects. The methods of macroscopic and microscopic quantitation of aggregates were evaluated. We preferred to use the macroscopic method, as the result of macroscopic readings correlated well with that of microscopic readings in our test system.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01924.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThe clinical significance and correlation of anti‐native DNA antibodies and immune complex level were evaluated in the present study. Anti‐DNA antibodies were measured by radioimmunoassay using I125‐labeled DNA and immune complex was screened using the polyethylene glycol precipitation method. Anti‐DNA antibodies of higher than 40 units/ml were found exclusively in patients with systemic lupus erythematosus, especially in patients with lupus nephritis. The level of anti‐DNA antibodies was found to be directly correlated with the disease activity. Higher amounts of circulating immune complexes could be found in patients with systemic lupus erythematosus, vasculitis, and other diseases. The patients with more active lupus erythematosus also tended to have higher amounts of immune complexes, but the correlation was not so definite. There was also no reliable correlation between anti‐DNA activity and immune co

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01925.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTHuman malignant melanoma cells and human squamous cell carcinoma cells were treated with cytochalasin B (CB)in vitroand observed with light and electron microscopes. When spindle‐shaped melanoma cells were treated with CB, they rounded up and their submembranous microfilaments (mf) (6 nanometers thick) vanished totally. After being released from CB after treatment for 10 days, they became flat and the submembranous mf reappeared to a nearly normal extent. Squamous cell carcinoma cells, when treated with CB, did not round up and the submembranous mf did not disappear.These results suggest that (i) submembranous microfilaments are not essential to make and keep certain types of cells round and (ii) the responses of cells to cytochalasin B are quite different in different cell

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01926.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTAn initial combination of moderated doses of prednisone or prednisolone and cyclophosphamide seemed to be rapidly effective in controlling pemphigus vulgaris and pemphigus foliaceus with minimal side effects. An appropriate schedule of treatment is proposed. The clinical response correlated very well with the decreased titers of pemphigus antibodies which became negative within six months. Elevated serum immunoglobulin levels returned to normal in most of the cases.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01927.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTProlonged friction and pressure on limited areas of the skin with other naked skin parts of the patient, occurring mostly from positional attitudes, as, for instance, resting the chin on the hands or knees while watching television, may cause peculiar cutaneous lesions. The occurrence of some cases of this dermatologic picture has led to the description of a dermatosis heretofore not reported that has been denominated traumatic anserine folliculosis (folliculosis anserina traumatica) — stressing the traumatic etiology, the goose skin (anserine) appearance and the follicular clinical aspect that may resemble keratosis follicularis.Up to now, 11 cases have been observed, occurring on the chin of 9 patients (also in both jaws of 1), on the right jaw of 1 and the neck of 1. The problem occurs mostly in children or young people; apparently delicate skin is an important factor. About 63.6% of the patients have an atopic background: On the points of friction and pressure ill limited patches of grouped, very small conical elevations are seen, either the same color as the patient's skin, or slightly hyperpigmented, with or without erythema and showing a goose skin (anserine) appearance. Tactilely, it resembles sand paper.The histopathology is characterized by varied but not intensive changes. In tissue sections may be seen: rudimentary follicles, follicular hyperkeratosis, focal increase of stratum lucidum, slight hypergranulosis, vasodilatation especially nearby the follicles, and small perivascular infiltration, predominantly lymphocyti

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01928.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01929.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTUrticaria pigmentosa occurred in both members of two pairs of twins. Identical blood typings, HLA histocompatibility and appearance strongly indicate that each pair of twins is monozygotic.Except for cutaneous lesions, there were no clinical or roentgenologic evidences of systemic mastocytosis. But latent diabetes mellitus was found in one member.Literature reporting monozygotic twins with urticaria pigmentosa will be discussed in this paper.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01930.x

年代:1979

数据来源: WILEY