ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02861.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTThis study reported 2 cases of subungual melanomas and analyzed, based on a questionnaire survey of 108 cases, clinical characteristics of Japanese subungual melanomas in relation to trauma history. We found (a) that subungual melanomas comprice about 10% of all cutaneous melanomas in Japan, (b) that 75% of them occur on fingers, particularly on the first finger, (c) that there is not a significant relationship between trauma history and occurrence or anatomic site of subungual melanomas, except for those of the right first finger where young males predominate and (d) that no differences exist in the histopathological types between the groups with and without trauma history. The relatively high incidence of subungual melanomas in Japanese appears to be related to genetic background and not directly to frequent exposure to trauma.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02862.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTThe influence of the route on the induction and persistence of delayed type hypersensitivity (DTH) reaction to alloantigens by epidermal cells (EC) and spleen cells (SC) was investigated. Subcutaneous (sc) or intraperitoneal (ip) administration of EC and SC induced DTH reactions but the DTH reaction by the ip route was weaker than that obtained by the sc route. Time course experiments have shown that DTH reactions induced by EC lasted at least 30 days, whereas DTH induced by ip injection of SC fell to an undiscernible level by day 14. DTH induced by sc injection of SC was significant at day 14, but became undiscernible by day 30. Intravenous (iv) injection of both EC and SC induced hyporesponsiveness after subsequent sensitization with allogeneic cells.Experiments using congenic strains of mice, EC treated with anti‐Ia antiserum and complement, and grafted skin revealed that H‐2, non‐H‐2, or Ia disparities were sufficient to induce DTH. Epidermal LC played an important role in DTH induction.Taken together, these results indicate the importance of LC in DTH induction and suggest the differing contributions of antigen presenting cells in the skin and other tissues in both induction and persistence of allo‐DTH

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02863.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTBullous dermatosis developed in three patients with renal failure who were on maintenance hemodialysis. On clinical and histological grounds, skin lesions were indistinguishable from those of porphyria cutanea tarda. A highly sensitive fluorimetric thin‐layer chromatographic technique was used for assay of porphyrin levels in plasma, urine, feces and dialysate. The porphyrin metabolism alterations observed in our three patients were not sufficiently uniform to be considered the cause of the bullous dermatosis. Uroporphyrinogen decarboxylase activities in red cells were also within normal limits. No other common etiological factors could be identified in our patient

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02864.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTOur previous study showed that a 0.1% concentration of griseofulvin (GF) in feed induced an abnormality of porphyrin metabolism in some dd‐K strain mice. To investigate the kind of changes in porphyrin metabolism that would be produced by other chemicals compared to the administration of 0.1% GF alone, estrogen, ethyl alcohol‐iron mixture and PCB was given to dd‐K strain mice. The numbers of mice with high liver protoporphyrin levels were increased in the group treated with both 0.1% GF and ethyl alcohol‐iron mixture, in comparison to the levels in the 0,1% GF alone and the ethyl alcohol‐iron mixture alone groups. A slight elevation in the liver protoporphyrin level was noted in only one mouse of the ethyl alcohol‐iron mixture group. The remaining mice showed normal levels. From this finding, it was presumed that the administration of ethyl alcohol‐iron mixture has the potential to intensify the activity of 0.1% GF alone. An elevation of the liver coproporphyrin and protoporphyrin levels was seen in the group treated with both 0.1 % GF and estrogen, as compared to the 0.1% GF alone and the estrogen alone groups. In those treated with estrogen alone, liver porphyrin levels were within normal limits except for one mouse, which showed an increase of liver protoporphyrin. An elevation of liver coproporphyrin and protoporphyrin was seen in 8 of 12 mice treated with both PCB and 0.1% GF, while there was no change in the PCB alone group. From these findings, it was inferred that the mechanism of abnormal porphyrin metabolism due to estrogen and PCB combined with 0.1% GF differs from the mechanism of abnormality due to 0.1% GF alone. It appears that the addition of some chemicals to a 0.1% GF feed enhances the action of the

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02865.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTAgglutinins toSporothrix schenckiiwere produced in rabbits by immunization withAspergillus fumigatus. Agglutination ofS. schenckiicells was inhibited by D‐galactose but not by D‐mannose. Indirect immuno‐scanning electron microscopy using rabbit anti‐A. fumigatusserum and ferritin conjugated goat anti‐rabbit IgG serum showed considerable labelling of ferritin particles at the cell surface ofS. schenckii; this behavior was inhibited by D‐galactose but not D‐mannose. These results suggested that galactose determinants were present at the cell surface ofS. schenckiiand that agglutinins toS. schenckiiwere divided into two groups, galactose‐reacting antibodies as well as the already recognized rhamnos

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02866.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTThe levels of NADPH oxidase and myeloperoxidase activities in leukocytes of twenty psoriatics were significantly raised over those of controls. Psoriatics were divided into three grades by the rule of nine: Grade I—less than 33% skin involvement, Grade II—33–66% and Grade III—over 66% involvement. A definite relationship between the percentage of surface area involved and level of the two activities was noted. They were elevated over control levels in all grades except for NADPH oxidase in grade I. There were significant increases in the activities of both enzymes in grade II as compared with

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02867.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTThe rate of cell proliferation in the basal cell layer after oral administration of aromatic retinoid was investigated with the cytofluorometric method. Guinea pigs were fed aromatic retinoid in daily doses of 5 mg/kg body weight for a period of 14 days. Epidermal cell suspensions were fractionated on colloidal silica polyvinylpyrrolidon to obtain a relatively pure fraction of basal cells. After being smeared on glass slides, they were stained with acridine orange. At 1 day after the administration, there was no change in the DNA distribution pattern. However, G0/G1ratio decreased strikingly. By 3 days, there was an increase in S cells. These results suggest that epidermal cell proliferation by oral administration of retinoid is due to the increase of cycling cells.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02868.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTWe report a 58‐year‐old female patient with von Recklinghausen neurofibromatosis who developed a condition similar to that of erythermalgia in many respects, especially on her hands. The distress worsened upon exposure to cold and improved when warmed. She felt pain over the hands restricted to the time of urination when her bladder was full. It was found that her distress was felt when blood was unstably forced through partial closing of abnormal a‐v shunts into diseased blood vessels of the distal extremities and that the a‐v shunts of this patient apparently worked diff

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02869.x

年代:1985

数据来源: WILEY

摘要:

ABSTRACTWe report two cases of verruciform xanthoma of the scrotal skin. In each case, the tumor was a single pink lesion with firm consistency and a granular surface. Each lesion was characterized histopathologically by papillomatous proliferation of the epidermis and dermis and dense foam‐cell infiltration of the region corresponding to the dermal papillary layer. These cells proved to be xanthoma cells that stained negatively or weakly positively with PAS, colloidal iron, and Alcian blue and strongly positively with Sudan III. No medical problems were found in either patient, and serum lipid levels were normal. This report also presents electron microscopic findings from scrotal verruciform xanthoma in one case and the results of lipid analysis of tumor tissue from both case

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1985.tb02870.x

年代:1985

数据来源: WILEY