ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01853.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTThe so‐called “colloid bodies” in lichen planus and lichen amyloidosus were observed ultrastructurally and compared with the changes of basal cells in “Futorafur dermatitis”, which occurs after long term administration of N1‐(2′‐tetrahydrofuryl‐5‐fluorouracil).The “colloid bodies” were located in the intercellular spaces in the epidermis and freely in the stroma of the upper corium. They were mainly composed of fine filaments, and frequently contained some melanosomes, mitochondria and other vacuolated structures. These filaments had a constant width about 70 to 80 Å in diameter, which was much the same as those of tonofilaments in an adjacent keratinocytes. A number of desmosomes, to which these filaments convergently adhered, were occasionally observed in “colloid bodies”. This finding seems to support the theory that these filaments are themselves tonofilaments originating from keratinocytes, and they are fundamentally differentiated from other types of filaments in the dermo‐epidermal junction areas. The degenerative processes of basal cells in the epidermis in the lesions of “Futorafur dermatitis” seemed to be identical to those in formation of “colloid bodies

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01854.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTAcid phosphatase of newborn rat epidermis was purified about 270‐fold by a procedure including acid treatment, CM‐cellulose, DEAE‐cellulose chromatography, and gel filtration on Sephadex G‐100. The purified enzyme had a pH optimum of 5.0 and an optimal temperature of 40°C. The enzyme was not activated by divalent cations, ethylenediaminetetraacetic acid or 2‐mercaptoethanol, and it was inhibited by p‐chloromercuribenzoate. The inhibition pattern by fluoride and by L(+) tartrate was competitive. The Km value for p‐nitrophenyl phosphate was 3.84×10−5M, and the molecular weight was about 73, 000. The enzyme appeared to be a nonspecific acid phosphatase. Intracellular localization of acid phosphatase in the epider

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01855.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTThis experiment was carried out in order to investigate the time sequence of tissue fibrinolytic activity in human skin following UVB or UVA after topically applicated psoralen using Todd's technique of fibrinolytic autography.Tissue fibrinolytic activity increased in the upper dermis for one to six hours after exposure to psoralen and subseqent UVA, when erythema responses were absent. The return to a normal pattern of fibrinolysis occured in the upper dermis 12–18 hours after treatment with psoralen and UVA, and then psoralen‐UVA‐induced erythema responses began. These responses were maximal 96 hours after treatment with psoralen and UVA, although no fibrinolytic activity was found in the upper dermis. Little change was observed in the lower dermal activity throughout the course of these responses.After UVB irradiation, a transient increase in fibrinolytic activity occured, with a normal pattern of lysis returning in the lower dermis at 12–18 hours. In the lower dermis an increase was observed at one to 6 hours although the activity in the upper dermis had already decreased. UVB erythema responses appeared within this period, were maximal at 6–12 hours, and declined gradually after 12 hours concomitantly with the activity in the upper and lower dermis. The upper dermal activity disappeared at 18 hours, while the lower dermal activity was not found after

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01856.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTThe relationship between skin surface lipids and transepidermal water loss (TWL) was investigated in 22 children with atopic skin.TWL values and casual and replacement lipids were measured by electro‐hygrometric and gravimetric methods respectively. Free and total cholesterol and squalene were measured by gas chromatography.The inverse correlations between casual lipids, especially total cholesterol, and TWL exhibited in the normal adult and juvenile skin were not found in the atopic skin.In addition, a significant increase in TWL and decrease in sebaceous lipids was characteristic of atopic skin.In conclusion, the inhibitory action of epidermal cholesterol on TWL is considered to exist only when the skin has a normal keratinization proces

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01857.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTA 29 year‐old woman who developed generalized erythematous eruptions after oral treatment with predonisolone tablets for facial dermatitis is described. Patch tests showed a positive reaction to both predonisolone tablets diluted in cream and a commercial predonisolone ointment. After oral challenges with 5mg predonisolone in tablet form and 4mg predonisolone powder, similar eruptions reappeared the next day. In both patch and dose testing with many kinds of corticosteroids, the patient showed a cross‐sensitivity to methyl‐predonisolone and its acetate

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01858.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTIt has been confirmed that an acquired periungual fibroma which developed in a 44 year‐old Japanese male X‐ray technician arose either in the dermis proximal to the nail matrix or between the proximal nail fold and the nail matrix. This disease may be a topographical variant of acquired digital fibrokerat

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01859.x

年代:1978

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1978.tb01860.x

年代:1978

数据来源: WILEY