ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01096.x

年代:1982

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01097.x

年代:1982

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01084.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTA case of a 72‐year‐old female with multiple syringomas of the clear cell type is reported. Ultrastructural observations revealed the following findings: 1) The tumor cells had the ordinary morphological features of usual syringoma cells. 2) The clear cells were rich in glycogen granules and various vacuoles. 3) Massive accumulations of glycogen granules surrounded by the unit membrane were occasionally observed. These electron microscopic findings were compatible with the light microscopic appearance of the clear cells. The tumor cells possessing characteristic clear cytoplasm can speculatively be regarded as altered syringoma cells with glycogen accumulation. The abnormal accumulation of the glycogen granules might be due to a kind of disorganized metabolism caused by diabetes mellitus in the syringoma ce

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01085.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTA patient with a 5 year history of hypersensitivity to mosquitoes developed a skin nodule on the chest, high fever, and hepatosplenomegaly. The diagnosis of malignant histiocytosis was made, based upon histological examination of the skin and cytological study of the pleural effusion. Immunological studies revealed the impaired activity of both T and B cells. After four weeks of no response to chemotherapy, the patient died. Autopsy revealed malignant histiocytes invading the bone marrow, liver, spleen, lung, adrenal glands, lymph nodes and skin. The possible relationship of immunodeficiency to malignant histiocytosis is discussed.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01086.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTAn adult case of kerion Celsi was reported. The patient was a 28‐year‐old housewife who lived in Tokyo. The fungus isolated was identified asTrichophyton tonsurans, indicating that this rare fungus can be isolated in Tokyo despite the lack of previous repo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01087.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTA case of cutaneous myxoid cyst with an ulcer on the nail plate of the right great toe is presented. This should be differentiated from subungual malignant melanoma.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01088.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTTo study the effect ofHerpes simplexvirus (HSV) on nervous tissue, we examined (1) the possibility of establishment of latent infectionin vitro, (2) the replication of HSV in mouse dorsal root ganglion and cerebellar cultures and (3) the effect of anti‐HSV rabbit serum on the maintenance of both cultures. Although both cultures without antibody were finally destroyed after inoculation, replication of HSV in cerebellar cultures was much higher than in the ganglion in both medium and tissue (P<0.005). Infected cultures treated with anti‐HSV antibody (CF: ×128) could survive longer in nerve cells of ganglion than in those of cerebellum.These results suggest that the ganglion can resist HSV infection and this makes latent infection poss

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01089.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThere are four independent stimulators (epinephrine, histamine, adenosine and prostaglandin E) of the adenylate cyclase receptor on the epidermal cell surface, all of which increase intracellular cyclic AMP. These stimulators and db‐cAMP inhibit epidermal cell proliferation and promote epidermal cell differentiation, although conflicting effects have been reported in pure epidermal cell culture systems. In order to elucidate the physiological roles of cyclic AMP in epidermal cells, endogenous protein phosphorylation of pig epidermal homogenates was studied. The autoradiographic analysis by SDS‐PAGE demonstrated that cyclic AMP (10μM) stimulated the phosphorylation of several epidermal proteins. One group of these endogenous substrates were keratinous proteins. These phosphoproteins were dephosphorylated by chelating Mg2+with EDTA. The addition of unlabeled ATP diminished the intensity of phosphoprotein bands.These results indicate that pig epidermal homogenates have cyclic AMP‐dependent protein kinase and that some endogenous substrates were keratinous pr

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01090.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThe results of the lupus band test (LBT) in New Zealand mice and MRL mice were reported. In NZB × NZW (B/W) F1mice, the deposition of immunoglobulin at the dermal‐epidermal junction (DEJ) was first observed in some mice at the age of six months and all were positive by the age of twelve months. A regional comparative study of LBT showed that the tail had the highest incidence. The deposition was in a granular or confluent pattern. In some of MRL‐lpr/lpr mice, LBT was positive at the age of two months and showed 90–100% positivity at over five months. The deposition revealed a confluent pattern with focal variation in density. In both strains the deposition of Ig G1at DEJ was most frequently demonstrated and circulating anti‐basement membrane antibodies were not observed.We discussed the similarities and differences between murine LBT and h

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb01091.x

年代:1982

数据来源: WILEY